Untitled Document

Date Prepared: November, 2012
Name: Atul Malhotra
Office Address: Sleep Disorders Research Program
Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115
Home Address: 98 Risley Road, Chestnut Hill, MA 02467
Work Phone: 617-732-5778
Work Email: amalhotra1@partners.org
Work FAX: 617-732-7337

Education
Year Degree
(Honors)
Fields of Study
(Thesis advisor for doctoral research degrees)
Institution
6/1988 B.S. Major: Chemistry University of Alberta, Edmonton, Alberta, Canada
6/1992 M.D.   University of Alberta

Postdoctoral Training
7/1992-6/1993 Intern Transitional St. Thomas Medical Center, Akron, OH
7/1993-6/1996 Resident Internal Medicine Mayo Clinic, Rochester, MN
7/1996-6/2000 Clinical and Research Fellow Pulmonary/Critical Care Medicine Harvard Medical School (HMS) Combined Program:
Massachusetts General Hospital (MGH), Brigham and Women’s Hospital (BWH), Beth Israel Deaconess Medical Center , BIDMC), and West Roxbury VA
Medical Center, Boston, MA
5/1998-6/2000 Research Fellow Medicine
PI: David P. White
Harvard Medical School

Faculty Academic Appointments
2000-03 Instructor Medicine Harvard Medical School,
2003-08 Assistant Professor Medicine Harvard Medical School
2008- Associate Professor Medicine Harvard Medical School

Appointments at Hospitals/Affiliated Institutions
6/1999- Staff Physician Sleep Sleep Health Centers, Boston, MA
7/2000- Assistant in Medicine Medical ICU Massachusetts General Hospital
7/2000- Associate Physician Medicine 
(Sleep Medicine, Pulmonary & Critical Care Medicine
Brigham and Women’s Hospital
7/2003- Staff Physician Pulmonary/Critical Care Beth Israel Deaconess Medical Center
2/2012- Attending Physician Intensive Care Unit King Faisal Hospital, Kigali, Rwanda
Major Administrative Leadership Positions
Local
2/2000- Co-Director, Health Science and Technology Respiratory Physiology and Pathophysiology (HST 100) Massachusetts Institute of Technology and Harvard Medical School, Boston, MA
7/2000- Co-Founder and Co-Organizer of weekly teaching session for Pulmonary and Critical Care and Anesthesia fellows MGH, BWH, BIDMC
4/2006- Medical Director Sleep Disorders Research Program
Brigham and Women’s Hospital
4/2006- Clinical Chief Division of Sleep Medicine, Brigham and Women’s Hospital
4/2008- Co-Director American Academy of Sleep Medicine  (AASM) Comprehensive Academic Sleep Program of Distinction for Brigham and Women’s Hospital
2/2011- Director of Clinical Training for HMS Sleep Division T32 Training Grant Sleep Medicine Division, Harvard Medical School

National
     
2005-2008 Director and Organizer, National Sleep Medicine Course American Academy of Sleep Medicine (AASM), held in Chicago, Il or Denver, CO
     
2010 Chairman and Organizer National Heart Lung and Blood Institute (NHLBI) workshop on Molecular Mechanisms Underlying Sleep Apnea, Bethesda, MD
2010-2011 Co-Founder and Co-Organizer/Director Sleep State of the Art Course for the American Thoracic Society (ATS), held in Miami, FL or San Diego, CA

Committee Service

Local
2006- Accreditation Council for Graduate Medical Education (ACGME) Fellowship Selection Committee Member, Brigham and Women’s Hospital
2006- Clinical Directors of Department of Medicine Member, Brigham and Women’s Hospital
2007- Editorial Board, Sleep and Health Education Member, Harvard Medical School
2007- Training Grant Writing Committee Member, Brigham and Women’s Hospital and Harvard Medical School,                   Co-Chairman since 2011-
(received priority score of 15)
2007- Tracking and Evaluation Sub-Committee Member, Harvard Medical School Sleep Medicine Division
2007- Trainee Selection Committee Member, Brigham and Women’s Hospital
2009- Faculty Review Committee Member, Harvard Medical School Sleep Medicine Division

National
2005- Abstract Reviewer Association of Professional Sleep Societies
Member
2008-2009 Program Committee International Sleep and Breathing Meeting, Pittsburgh, PA
Member
2008-2009 Advisory Committee International Dyspnea Symposium
Member
2009- End Point Adjudication Committee Pfizer, New York
2010 Data Safety Monitoring Board (DSMB) University of Pennsylvania, Cardiovascular Effects of Obstructive Sleep Apnea (COSA) study
Member
2011 Future Research Needs in the Diagnosis of Obstructive Sleep Apnea Agency for Healthcare Research and Quality (AHRQ)
Expert Member
     
2011 DSMB University of Pennsylvania Program Project Grant, Philadelphia, PA
Member
2011 Advisory Committee Comparative Outcomes Management with Electronic Data Technology (COMET) Study , Stanford University, Palo Alto, California
Expert Member
2011 DSMB American Lung Association study
Member
2012- Abstract Review American Society of Clinical Investigation (ASCI) and American Association of Physicians (AAP)
Reviewer for annual meeting
2012- Sleep and Circadian Rhythm External Advisory Group Canadian Institute of Health Research (CIHR)
Member

International
2006 PhD Thesis Review Committee University of Melbourne, Victoria, Australia
Member
2006 Program Committee International Sleep and Breathing Meeting, Queensland, Australia
Member
2010- Expert Advisory Panel - Respiratory Treatment Strategies - The Cambridge Research Centre (Cambridge, UK)
Member
2011 Expert Review Panel Biomedical Research Council: Agency for Science, Technology and Research, Singapore
Member
2011 PhD Thesis Review Committee All India Institute of Medical Sciences, New Delhi, India
Member
2012 PhD Thesis Review Committee University of Manitoba, Canada
Member
2012 PhD Thesis Review Committee University College Dublin, Ireland

Professional Societies
Society of Critical
Care Medicine
1994- Member
  2006-2009 Adult Multidisciplinary Critical
Care Knowledge Assessment Program
Member

  2010-2013 Research Committee
Member
American College of Chest Physicians 1996- Member
Royal College of Physicians and Surgeons of Canada 1997- Fellow
American Academy of of Sleep Medicine 1998- Member
  2004-2007 National Sleep Medicine Course
Director
  2005 Nominating Committee of Sleep
Disorders Breathing Section
Chairman
  2007- Academic Affairs Committee
Member
  2010- Academic Affairs Committee
Vice Chairman
  2010-2011 AASM Future of Sleep Medicine Task Force
Invited Member
  2011- Fellow
Sleep Research Society
(SRS)
2005-2008 Member
American Thoracic Society (ATS) 1996- Member
  2001-2008 Program Committee for Respiratory Neurobiology and Sleep
Member (2003-2005)
  2003-2005 Program Committee for Respiratory Neurobiology and Sleep
Chairman
  2004- Respiratory Neurobiology of Sleep
Executive Committee
Member
  2005-2008 Training Committee
Member
  2005-2008 Review of Educationally Focused
Proposals, Education Committee
Chair
  2006-2009 Leadership Group of American Thoracic Society and European Respiratory Society
Member

  2006-2009 International Conference Advisory Group Member
  2006-2009 Education Committee
Chairman
  2006-2009 Documents Committee
Member
  2006-2009 Clinician’s Advisor Committee
Member
  2006-2008 Website Editorial Board
Member
  2007-2008 Nominating Committee for Respiratory Neurobiology of Sleep Assembly
Elected Member
  2008-2011 Sleep and Respiratory Neurobiology
Assembly
Elected Chairman
  2009-2011 Board of Directors
Elected Member
  2010-2011 Documents Review Board of Directors
Chairman
  2011-2012 Comparative Effectiveness Research Group
Member
  2012- Membership Committee
Member
  2012-2017 Member, Executive Committee
  2012 Elected Secretary Treasurer
  2013 Vice-President
  2014 President-Elect
  2015 President
  2016 Past-President
Society of Anesthesia and Sleep Medicine (SASM) 2011 Founding Member
  2012- Continuing Education Committee
Member
  2012- Research and Clinical Committee
Member
American Society of Clinical Investigation and American Association of Physicians 2012- Abstract reviewer for annual meeting  
Critical Care
Society Collaborative
(CCSC)
2012- Executive Committee
Member
Association of Pulmonary and Critical Care medicine Program Directors/
ACCP/ATS Education Research Award (AERA) Review Committee
2012- Member, representative from ATS Executive Committee
Grant Review Activities
2003 Grant & Thesis Reviewer Health Research Board, Dublin, Ireland

 
2005 Grant Reviewer (ad hoc), Study Section National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), National Institutes of Health (NIH), Bethesda, MD
2005 Grant Reviewer University of Western Australia, Perth, Australia
2006- Grant Reviewer, Study Section
Standing Member (2006-2009)
Ad hoc reviewer 2011-
American Heart Association (AHA), Dallas, TX
2006-2009 Grant Reviewer, Beeson Grant Study Section
Standing Member
National Institute of Aging (NIA), National Institutes of Health, Bethesda, MD
2008 Grant Reviewer, Program Project National Heart Lung and Blood Institute (NHLBI)
2008- Grant Reviewer, Loan Repayment (annually)
Standing Member
National Institute of Aging, Bethesda, MD
2009-2011 K23 Study Section
Standing Member
National Institutes of Health
2009- Respiratory Integrative Biology and Translational Research (RIBT) Study Section
Ad Hoc Reviewer
Standing Member 2011
National Heart Lung and Blood Institute, NIH
2009- Grant Reviewer National Institute of Aging (NIA)
2010 Ad Hoc Reviewer  NIDDK
2011- Ad Hoc Reviewer NHLBI R13 applications
2011- Review Committee Member, Vision Grants Society of Critical Care Medicine
2011 Grant Reviewer National Medical Research Council Singapore
     
2012- Sleep and Circadian Rhythm External Advisory Group  (grant review) Canadian Institute of Health Research (CIHR)

Editorial Activities
Ad Hoc Reviewer
Mayo Clinic Proceedings
Sleep
European Respiratory Journal
New England Journal of Medicine
Journal of Applies Physiology
Journal of Clinical Endocrinology and Metabolism
Archives of Internal Medicine
Sleep Medicine Reviews
Circulation
American Journal of Epidemiology
Anesthesiology
Respiratory Research
Critical Care
Journal of the American College of Cardiology
American Journal of Physiology
Journal of the American Medical Association (JAMA)
Annals of Medicine
Medical Hypotheses
Other Editorial Roles
2005- Member, Editorial Board Chest
2005- Member, Editorial Board American Journal of Respiratory and Critical Care Medicine
2008- Member, Editorial Board Sleep
  2009- Associate Editor
2009 Guest Editor Progress in Cardiovascular Diseases, issues 51(4) and 51(5)

Honors and Prizes
   
1984-88 Province of Alberta Scholarship Alberta Government First Class Standing and named to Dean’s Honor Roll in undergraduate sciences
1992 Rajcoomarie Singh Memorial Achievement Award Rajcoomarie Singh Memorial Outstanding achievement in medical school
1992 Ciba book prize for academic achievement Ciba Pharmaceuticals Outstanding achievement in medical school
1992 First Class Standing University of Alberta Medical School  

1992-93 Intern of the Year St. Thomas Medical Center  
1996 Gold Medal Mayo Clinic Outstanding Achievement Award in Residency
2000 Trainee Research Merit Award Associated Professional Sleep Societies, Las Vegas, NV Outstanding Research
2001 Teacher of the Year Massachusetts General Hospital Internal Medicine Residents Visiting Teaching Award
2001 Teacher of the Year Harvard Combined Fellowship (BWH, MGH, BIDMC) Pulmonary and Critical Care fellowship award
2003- International Health Professional of the Year International Biographic Centre, Cambridge, UK  
2005 Young Investigator Award, Respiratory Neurobiology and Sleep American Thoracic Society International Conference, San Diego, CA Outstanding research potential
2006 Certificate of Appreciation American Thoracic Society Outstanding contribution
2008 Presidential Citation Society of Critical Care Medicine Outstanding contribution
2008 The Harvard Pulmonary and Critical Care Senior Fellows’ Teaching Appreciation Award Harvard Medical School Award for outstanding teaching and dedication to teaching
2009 Certificate of Appreciation American Thoracic Society Session on “How to pick a mentor”
2009 Certificate of Appreciation National Heart Lung and Blood Institute E-mentoring initiative
2010 Certificate of Appreciation American Thoracic Society Center for Fellows and Junior Professionals
2010 Top Reviewer Award Chest Top 5% of journal reviewers
2010 Best Doctors in America Best Doctors Selected by peers
2011 Fellow American Academy of Sleep Medicine FAASM (Fellow of the American Academy of Sleep Medicine)
2011 Outstanding Contribution American Thoracic Society ATS Board of Directors
2011 Member American Society for Clinical Investigation (ASCI) Council member for honorific society (convocation 4/11)
2012 Member Leading Health Professionals of the World Selected by International Biographical Centre (IBC) Cambridge, England
Report of Funded and Unfunded Projects
Funding Information 
Past
Grant title Grant title
Grant type and number
Role on Project (if PI or site PI, total direct costs)
Description of the major goals
1998-2008 Harvard Center on Sleep Neurobiology and Sleep Apnea
NIH/NHLBI P50 HL060292 (SCOR – Specialized Center of Research)
Co-Investigator (1998-2006), Total Direct Costs $1.3M
Major Goal: To study the basic and physiological mechanisms underlying sleep and sleep apnea.
2000-2002 The Influences of Aging, Gender and Obesity on Upper Airway Structure, Function and Ventilatory Stability
American Heart Association Beginner’s Grant in Aid
Principal Investigator, Total Direct Costs $100K
Major Goal: To define the mechanisms underlying epidemiological risk factors for sleep apnea.
2000-2003 The Influences of Aging, Gender and of Obesity on Upper Airway Structure, Function and Ventilatory Stability
Medical Research Council Canada, Clinician Scientist Award
Principal Investigator, Total Direct Costs $135,327
Major Goal: To define the mechanisms underlying epidemiological risk factors for sleep apnea.
2001-2005 The Influences of Aging, Gender and Obesity on Upper Airway Structure, Function and Ventilatory Stability
American Heart Association Scientific Development Grant
Principal Investigator, Total Direct Costs $304, 912
Major Goal: To define the mechanisms underlying epidemiological risk factors for sleep apnea.
2003-2010 Sleep Apnea and Obesity: Cardiovascular Risk Assessment
R01 HL73146
Principal Investigator, Total Direct Costs $1,086,487
Major Goal: To understand the independent roles of sleep apnea and obesity on cardiovascular biomarkers.
2004-2008 The Mechanisms Underlying the Aging Predisposition to Obstructive Sleep Apnea
National Institutes of Aging, Paul B. Beeson Award AG024837
Principal Investigator, Total Direct Costs $697,727
Major Goal: To understand why people develop sleep apnea with aging.
 
2006-2008 Sleep and the Control of the Pharyngeal Musculature 
P50 HL060292-09
Principal Investigator, Total Direct Costs $ 477,335 (for 2 years)
Major Goal: To understand the interactions between pharyngeal anatomy, upper airway muscle control and ventilatory instability in the pathogenesis of sleep apnea.
2008-2009 Sepracor: Use of Eszopiclone to Alter Upper Airway mechanics
Principal Investigator, Total Direct Costs $261K to SHC
Major Goal: To assess the role of eszopiclone on upper airway mechanics in rodents and in humans
2007-2008 Philips Respironics: Positive Airway Pressure for the Treatment of Asthma
Principal Investigator, Total Direct Costs $200K to SHC
Major Goal: To perform pilot studies using Bi-Flex with Auto to determine whether lung stretch can affect bronchomotor tone during sleep
2007-2008 Philips Respironics: Use of Bi-Flex with Auto to Rescue Patients with a poor initial experience with CPAP
Principal Investigator, Total Direct Costs $89K
Major Goal: To test the hypothesis that newer technology is better than standard of care CPAP to treat patients with a poor initial experience with CPAP
2011-2012 Sleep Group Solutions: Using of acoustic pharyngometry to assess patients at risk of sleep apnea and adherence to CPAP therapy
Principal Investigator, Total Direct Costs $51K
Major Goal: To assess rhinometry and pharyngometry in patients undergoing a protocol for occupational sleep medicine assessment with a view towards defining objective indices to predict OSA (without the need for subjective report) and possibly to predict adherence with CPAP therapy.
  Current
Grant title Grant title
Grant type and number
Role on Project (if PI or site PI, total direct costs)
Description of the major goals
2008-2013 Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea Pathogenesis
R01 HL085188-01A2
Principal Investigator, Total Direct Costs $1,022,456
Major Goal: To perform newer electrophysiological techniques on the upper airway muscles with a view towards defining new therapeutic targets for sleep apnea.
2008-2013 Targeted Sleep Apnea Therapy by Identifying Underlying Mechanisms
0840159N
American Heart Association (AHA) Established Investigator Award
Principal Investigator, Total Direct Costs $454, 545
Major Goal:  To identify potential therapeutic targets for sleep apnea by defining underlying mechanisms
2009-2013 Mechanisms Underlying the Aging Predisposition to Obstructive Sleep Apnea
R01 HL090897-01A2
Principal Investigator, Total Direct Costs $1M
Major Goal:  To characterize thoroughly the various mechanisms underlying sleep apnea with a view towards defining why older people are susceptible to sleep apnea
2009-2014 Assessment of Upper Airway Mechanics Using Newer Electromyographic Techniques
K24 HL 093218 – 01 A1
Principal Investigator, Total Direct Costs $803K
Major Goal: A mentoring award to protect the PI’s research time for development of young trainees
2009-2014 Program Project Grant
1 P01 HL 095491 - 01 A1
Mechanisms of State Switching in Sleep and Sleep Apnea
Overall PI: Saper, PI of Project 2: Malhotra; Total Direct Costs $1.25M for Brigham Site
Major Goal:  To identify the neural circuitry involved in arousal from sleep and to assess the possible role of arousal in the pathogenesis of sleep apnea.
2010-2015 The Modifying the Impact of ICU-Associated Neurological Dysfunction (MIND-USA) Multicenter Clinical Trial  
R01- AG035117-01
Overall PI: Ely, Brigham PI: Malhotra; Total Costs: $1.5M/year
Major Goal:  To test the hypothesis that anti-psychotic therapy leads to improvement in outcomes among critically ill patients with delirium.
2011-2016 Obstructive Sleep Apnea Increases Cardiovascular Risk in Type 2 Diabetes
1R01HL110350-01A1
MPIs: Malhotra and Veves; Total Costs: $871K/year
Major Goal: To assess the impact of sleep apnea on cardiovascular outcomes in patients with diabetes.
2012-2016 Esophageal Pressure to Guide Mechanical Ventilation in  acute respiratory distress syndrome (ARDS)
UM1HL108724
PIs: Talmor and Loring; Brigham PI: Malhotra; Total Costs: $1.5M
Major Goal:  To test the role of esophageal manometry in setting mechanical ventilator in ICU patients with acute respiratory distress syndrome.
2012- Apnex Medical, Hypoglossal Nerve Stimulator Study (HGNS)
Overall PIs: Malhotra, Kezirian; Direct Costs: depend on patient enrollment
Major Goal: To perform a multinational randomized trial to study HGNS for treatment of obstructive sleep apnea
 
Report of Local Teaching and Training
Teaching of Students in Courses
Year(s) Course Title Location
  Type of student/audience Level of Effort
1997- Patient-Doctor II – Respiratory System
Medical School Students
Harvard Medical School
5 hours preparation time per session, 5-10 sessions per year
1998- Health Science and Technology – Respiratory Physiology and Pathophysiology for MD and PhD students Massachusetts Institute of Technology and Harvard Medical School
20 hours preparation time per lecture, 3 lectures per year
15 hours preparation time per session, 6 sessions per year

Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs)
Year(s) Title Location
Type of student/audience Level of Effort
2000- Weekly lecture to Pulmonary & Critical Care and Anesthesiology fellows regarding current clinical and research topics in current basic and clinical literature MGH, BWH, BIDMC (in addition to duties as co-director and organizer), 10 hours of preparation per week
2000- Regular lectures to house officers at all of the major teaching hospitals including BWH, MGH and BIDMC, roughly 1-2 per month (Pulmonary, Critical Care, Sleep Medicine) BWH, MGH and BIDMC

Clinical Supervisory and Training Responsibilities
Year(s) Type of responsibility Level of Effort
1999-2000 Attending Physician, Intensive Care Unit, Medical and Surgical West Roxbury VA Medical Center One month per year
2000-2002 Attending Physician, Surgical Intensive Care Unit Brigham and Women’s Hospital 6-8 weeks per year
2000-2004 Attending Physician Medical Intensive Care Unit Massachusetts General Hospital 8 weeks per year
2005-2008 Attending Physician Medical Intensive Care Unit Beth Israel Deaconess Medical Center 8 weeks per year
2006- Preceptor
Sleep Medicine fellows
Brigham and Women’s Hospital 1-2 half days per week
2006- Polysomnography Interpretations, supervision of fellows Brigham and Women’s Hospital 1 half day per week

Laboratory and Other Research Supervisory and Training Responsibilities

Year(s)
Type of responsibility Level of Effort
2000- Mentor/advisor to trainees/junior faculty from all major Boston teaching hospitals 3-4 hours per week
Based on the breadth of my research and my substantial contacts within my field, I frequently serve as a mentor/advisor to trainees at all of the major teaching hospitals in Boston.  I have provided advice to many trainees about manuscript preparation, data synthesis/interpretation, mentor/mentee conflicts, granting mechanisms, response to reviewers and faculty position negotiations.  Based on the success of my trainees, I am frequently called upon to serve in this role from individuals from diverse backgrounds/experience.  In total I spend roughly 3-4 hours per week in this role and have an open door policy for these types of interactions.  These interactions began in 2000 and became more frequent in 2006-present when I achieved the position of Medical Director of the Sleep Disorders Research Program. Formally Supervised Trainees

Year(s)
Name and degrees/ Current position
Describe the type of supervision and the specific accomplishments of your trainee that occurred as a direct result of your supervision (maximum one sentence)
1999 Stephanie Crowley (summer student)
Current position: Assistant Professor, Rush University, Chicago, Il
2001 Stan Lazic (summer student)
Current position: Research scientist, Hoffman La-Roche Laboratories, Lausanne, Switzerland
2001- Andrew Wellman, MD (post-doctoral fellow)
Received RO1 funding from NHLBI
Current position: Instructor in Medicine, Harvard Medical School (promotion pending)
2002-04 Michael Stanchina, MD (post-doctoral fellow)
Current position: Assistant Professor, Brown University, Providence, Rhode Island
2003-05 Amy Jordan, PhD (post-doctoral fellow and Instructor in Medicine), Harvard Medical School
Received AHA Scientific Development Grant funding (co-mentor: Malhotra)
Amy has 58 publications to date, including 39 with Malhotra as co-author
Current position: Roper Fellow  at University of Melbourne, Melbourne, Australia
2005-06 Kate Steiner, MD (post-doctoral fellow)
Current position: Attending Physician, UMass Medical Center, Worcester, MA
2005-06 Andrew Nguyen, MD (post-doctoral fellow)
Current position: Attending Physician, McGill University, Montreal, Quebec, Canada
2005-06 Ednan Bajwa, MD (resident and fellow)
Now K23 funded from NHLBI (co-mentor: Malhotra) and has 19 original publications to date.
Current position:  Director, Massachusetts General Hospital, Medical Intensive Care Unit
2005-07 Matthias Eikermann, MD (post-doctoral fellow)
Has 73 publications to date, with the majority as first or last author.
Current position: Assistant Professor of Anesthesiology, Massachusetts General Hospital
2005-08 Susie Yim Yeh, MD (post-doctoral fellow)
Won the Pickwick Fellowship from the National Sleep Foundation and Young Investigator Award from International Sleep & Breathing (Primary Mentor: Malhotra)
Current position: Attending Physician, Kaiser Permanente, Anaheim, CA
2006-07 Yulun Lo, MD (post-doctoral fellow)
Current position: Assistant Professor, University of Taiwan, Taipei, Taiwan
2006-08 Shilpa Rahangdale, MD (post-doctoral fellow)
Awarded a research grant from the American Sleep Medicine Foundation (Primary Mentor: Malhotra).
Current position: Attending Physician, North Shore University Health System, Chicago, IL
2006-08 Suzanne Bertisch, MD, MPH (post-doctoral fellow)
Received her K23 award in July 2009 (co-mentor: Malhotra).
Current position: Instructor in Medicine, Harvard Medical School
2006-2009 Danny Eckert, PhD (post-doctoral fellow)
Won the Allen & Hanbury and CJ Martin Awards (Australia)
and was funded with an AHA Scientific Development Grant (primary mentor: Malhotra).
He has 39 publications to date, 14 as first author.
Current position: University of Sydney junior  faculty, Sydney, Australia with 3 awards from NHMRC
2007- Lisa Campana, BS
PhD student, Boston University, Boston, MA (primary mentor: Malhotra)
Current position: post-doctoral fellow, Harvard Medical School
2007- Julian Saboisky, PhD, post-doctoral fellow
Awarded AHA funding and SRS travel award for his research (Primary mentor: Malhotra).
Current position: Research Fellow, University of Sydney, Australia
2008- Robert Owens, MD
Pulmonary and Critical Care Fellow, Brigham and Women’s Hospital
Received a National Research Service Award in July 2009 and received his K23 from NHLBI in September 2011 (primary mentor: Malhotra).
Current position: Instructor in Medicine (promotion pending), Harvard Medical School
2008- Lichuan Ye, RN, PhD
Awarded a grant from Sigma Theta Tau Honor Society of Nursing and received a fundable score on an NIH R15 grant.
Current position: Assistant Professor, Boston College, Chestnut Hill, MA
2008- Shamim Nemati, BEng
Current position: Graduate Student,  Massachusetts Institute of Technology, Cambridge, MA
Awarded a James S. McDonnell Foundation Postdoctoral Fellowship Program
2008- Ina Djonlagic, MD
Research fellow and junior faculty
Awarded two grants from the American Sleep Medicine Foundation and recently a K23 from NHLBI (primary mentor: Malhotra)
Current position: Instructor in Medicine, HMS; Division of Sleep Medicine, BWH
2009-2010 Jay Balachandran, MD
Pulmonary and Critical Care Fellow, Brigham and Women’s Hospital
Current position: Assistant Professor, University of Chicago, Chicago, IL
   
2009- Bradley Edwards PhD, Melbourne, Australia (post-doctoral fellow)
Won the Allan & Hanbury and CJ Martin awards for his research proposal (primary mentor: Malhotra).
  Current position: Research Associate, Sleep Disorders Program, BWH/HMS
2010- David McSharry, MBBS
Received AHA post-doctoral fellowship (primary mentor: Malhotra)
Current position: Research and Clinical Fellow, BWH/HMS
2010- Scott Sands, PhD student, Monash University, Melbourne, Australia
Received AHA post-doctoral fellowship award (co-mentor: Malhotra)
Received CJ Martin research award
Current position: research post-doctoral fellow, BWH/HMS
2010- Jessica Noggle, PhD, Boston, F32 award (co-mentor: Malhotra)
Current position: post-doctoral fellow, BWH/HMS
2010- Eric Kezirian, MD, MPH
Received K12 award (remote mentor: Malhotra)
Current position: Assistant Professor of Otolaryngology, UCSF, San Francisco, CA
2011- Pedro Genta, MD
Received Sao Paulo Research Foundation (FAPESP) grant (primary mentor: Malhotra)
Current position: post-doctoral fellow, Malhotra laboratory
2011- Mihaela Teodorescu
Received: Merit Award  from the Department of Veteran Affairs (VA) (remote mentor: Malhotra).
Current position: Assistant Professor, University of Wisconsin (Madison), Madison, WI
2011- Karim Awad, MD
Received: AHA Fellow to Faculty Award (Primary Mentor: Malhotra, award relinquished).
Current position: Post-doctoral Fellow,  Division of Sleep Medicine, BWH
2012- Natalie Shaw, MD)
Received K23 award from NIH (co-mentor: Malhotra),
Current position: Instructor in Medicine, Harvard Medical School
  Formal Teaching of Peers (e.g., CME and other continuing education courses)
No presentations below were sponsored by outside entities.
Year(s) Title(s) or topic(s) or talks Number of talks in a single course
Course Name (Sponsor, if any) Location(s) (city or country)
2000-2003 Harvard Advances in Sleep Medicine CME Course
Meet the Professors Session
topic: sleep apnea
One lecture per course
Boston, MA
2001-2004 Massachusetts General Hospital
Pulmonary and Critical Care Unit CME Course
Topic: Sleep apnea and meet the professors
One lecture per course
Boston, MA
2008 Harvard Obesity Surgery Symposium
topic: sleep apnea
Invited talk
Boston, MA
2009 Harvard Trauma ICU CME Course
Topic: mechanical ventilation in acute respiratory distress syndrome (ARDS)
Lecture
Boston, MA  
2009-2011 Harvard CME Course on Obesity
topic: sleep apnea
One lecture per course
Boston, MA
2011 Brigham and Women’s Pulmonary and Critical Care video CME Course
topic: sleep apnea
Lecture
Boston, MA
Local  Invited Presentations
No presentations below were sponsored by outside entities.
Year(s) Title of presentation/ Type of presentation
  Department and Institution where presented (Sponsor, if any)
1996-2004 Medical House Staff Lectures/ Resident Report/ “Firm Chief” Rounds,
Massachusetts General Hospital
various topics in pulmonary, critical care, sleep medicine, ~ 5 per year
1996-98 Pulmonary Grand Rounds, ~ 5 per year
Massachusetts General Hospital
clinical topics in pulmonary and critical care medicine
1997-2000 Harvard Combined Pulmonary and Critical Care Fellowship Lectures, ~ 3 per year
2000-2004 Medical Intensive Care Unit Teaching Lectures, roughly 1 per month
Massachusetts General Hospital
topics include acid/base, hemodynamics, ARDS, sepsis
2000 Rheumatology Case Conference
Brigham and Women’s Hospital

2000 Anesthesiology Grand Rounds
Brigham and Women’s Hospital
topic: mechanical ventilation   
2001 Trauma Grand Rounds
Brigham and Women’s Hospital
topic: ARDS
2001 Surgical Grand Rounds, Mortality and Morbidity Conference
Brigham and Women’s Hospital
topic: ARDS
2001 Sleep Grand Rounds
Sleep Medicine Division, Brigham and Women’s Hospital
topic: upper airway physiology
2001 Neurogroup Meeting
Harvard School of Public Health
2001 Pulmonary and Critical Care Grand Rounds
Massachusetts General Hospital
Topic: upper airway physiology
2001-2005 Surgical ICU Course: Current State of Critical Care Medicine
Brigham and Women’s Hospital
various topics in critical care medicine
     
2002 Medical Grand Rounds
Massachusetts General Hospital
topic: sleep disordered breathing in congestive heart failure
   
2002 Neurology Critical Care Conference
Massachusetts General Hospital
topic: acid/base 
2002 Anesthesiology Teaching Conference
Massachusetts General Hospital
topic: heart/lung interactions
2004 Anesthesiology Grand Rounds
Beth Israel Deaconess Medical Center, Boston, MA
topic: heart/lung interactions
2005-2007 Partners Healthcare Physicians’ Day lecture/discussion and small group sessions
Boston, MA
2006 Pulmonary Grand Rounds
Longwood Medical Area
Boston, MA
topic: clinical update on sleep disorders
2006 Anesthesiology Grand Rounds
Brigham and Women’s Hospital
topic: controversies in critical care
2006 Cardiology Grand Rounds
West Roxbury VA Medical Center, West Roxbury, MA
topic: sleep in the cardiac patient
2007 Allergy/Immunology Grand Rounds
Massachusetts General Hospital
topic: sleep apnea
2007 Anesthesiology Grand Rounds
Beth Israel Deaconess Medical Center
topic: mechanical ventilation
2007 Diabetes Research Meeting
Massachusetts General Hospital
topic: sleep apnea
2008 Obesity Grand Rounds
Massachusetts General Hospital
topic: sleep apnea
2008 Pediatric Sleep Conference
Massachusetts General Hospital
topic: upper airway
2009 Pulmonary and Critical Care Grand Rounds
Brigham and Women’s Hospital
topic: future of sleep apnea therapy
2009 Anesthesiology Grand Rounds
Massachusetts General Hospital
topic: mechanisms underlying sleep apnea
2009 Pulmonary and Critical Care Grand Rounds
Massachusetts General Hospital
topic: sleep apnea pathogenesis
2010 Pulmonary Grand Rounds
Brigham and Women’s Hospital
topic: Controversies in critical care
2010 Endocrinology Grand Rounds
Massachusetts General Hospital
topic: endocrine aspects of pulmonary/critical care and sleep medicine
2010 Fish Center for Women, invited lecture
Brigham and Women’s  Hospital, Boston, MA
topic: interactive discussion about sleep disorders
2010 Medical Grand Rounds
Faulkner Hospital, Boston, MA
topic: sleep apnea
2010- Primary Care Outpatient lectures (~ quarterly)
Brigham and Women’s Hospital
various topics in pulmonary/critical care and sleep medicine
2011 Anesthesiology Grand Rounds
Brigham and Women’s Hospital
topic: future of sleep apnea therapy
2011 Center for Functional Pulmonary Imaging, invited lecture
Brigham and Women’s Hospital
topic: novel therapeutic targets in the upper airway
2011 Endocrinology Grand Rounds
Brigham and Women’s Hospital
topic: endocrine aspects of pulmonary/critical care and sleep medicine
2012 Oral and Maxillofacial Surgery Grand Rounds
Massachusetts General Hospital
topic: sleep apnea therapeutic targets
2012 Pulmonary and Critical Care Grand Rounds
Massachusetts General Hospital
topic: controversies in critical care
2012 Sleep and Shift Work: Optimizing Productivity and Health Management in the 24/7 Global Economy conference, invited lecture and panel discussion
Harvard School of Public Health
2012 Anesthesiology Grand Rounds
Massachusetts General Hospital
Topic: sleep deprivation

2013 Anesthesia, Critical Care and Pain Medicine Grand Rounds
Beth Israel Deaconess Medical Center
Topic: perioperative risk of sleep apnea
  Report of National and International Invited Teaching and Presentations
No presentations below were sponsored by outside entities.
Invited Presentations and Courses  
Regional:

2001-2003
Cardiopulmonary pathophysiology (undergraduate course, one lecture annually)
Boston University, Boston, MA
topic: upper airway physiology
2002 Pulmonary Grand Rounds
St. Elizabeth’s Hospital, Boston, MA
topic: 10 things to think about in sepsis
2002 Pulmonary Grand Rounds
St. Anne’s Hospital, Fall River, MA
topic: sleep apnea
2002   Medical Grand Rounds
Southern New Hampshire Medical Center, Nashua, NH
topic: idiopathic pulmonary fibrosis
2004 Cardiology Grand Rounds
Boston University, Boston, MA
topic: cardiovascular complications of sleep apnea
   
2004 Medical Grand Rounds
Shattuck Hospital (Tufts University), Jamaica Plain, MA
topic: chronic obstructive pulmonary disease
2004- General Systems Physiology Lecture
Massachusetts Institute of Technology, Cambridge, MA
topic: control of breathing
2004 Pulmonary Research Conference
Brown University, Providence, RI
topic: sleep apnea pathogenesis
2005 North East Sleep Society, invited lecturer
Stamford, CT
topic: upper airway physiology
2009 Pulmonary Journal Club
Boston University, Boston, MA
topic: mechanical ventilation
2010 Future of Clinical Sleep Medicine meeting, invited discussant
Sleep HealthCenter, Dedham, MA
topic: panel discussion
2010 Cardiometabolic Health Congress (CMHC), invited speaker
Boston, MA
topic: sleep apnea
   
2011 Institute of Electrical and Electronics Engineers (IEEE) Engineering in Medicine and Biology Society 33rd annual meeting, invited lecture
Boston, MA
topic: control of breathing
2011 Future of Clinical Sleep Medicine meeting, invited lecturer
Sleep HealthCenter, Dedham, MA
topic: sleep apnea therapy
2012 Critical Care Grand Rounds
Tufts Medical Center, Boston, MA
Topic: critical care controversies
20121 American Association of Sleep Technologists meeting
Boston, MA
topic: central sleep apnea
2013 Experimental Biology (FASEB)
Boston, MA
Topic: sleep apnea biomarkers
  National   

Year(s)
Title of presentation or name of course/ Type of presentation/role(s) (note if presentation the result of a selected abstract)
Location (Sponsor, if any)

2002 Meet the Professors Session
American Thoracic Society, Atlanta, Georgia
topic: central sleep apnea
2002 Pulmonary and Critical Care Medicine Grand Rounds
New York University, New York, NY
topic: sleep apnea pathogenesis
2003 Laboratory for Biomedical Science
North Shore Long Island Jewish Hospital, New York
topic: autonomic physiology in sleep apnea
2004 American College of Cardiology annual meeting, New Orleans, LA
topic: sleep apnea and hypertension and sleep apnea in congestive heart failure
2004 Mayo Clinic, Rochester, MN, invited speaker
topic: sleep apnea pathogenesis
2004 Pulmonary Grand Rounds
University of California, San Francisco, CA
topic: sleep apnea pathogenesis
2004 Surgery, Sleep, and Breathing Meeting, invited speaker
Milwaukee, WI
topic: cardiovascular complications of apnea
2004 National Sleep Medicine Course: Central Sleep Apnea
American Association of Sleep Medicine, Chicago, IL
2005 University of Michigan, Ann Arbor, MI, invited speaker
topic: sleep apnea pathogenesis
2005 Advanced Sleep Medicine Course
American Association of Sleep Medicine, Miami, FL
topic: central sleep apnea and stump the expert
2005 National Sleep Medicine Course
Chicago, IL
topic: respiratory physiology and central sleep apnea
2005 Review Course, Sleep 2005, invited lecturer and Meet the Professors Session
Phoenix, Arizona
topic: sleep apnea pathogenesis/sleep apnea treatment 
2005 Carolina Sleep Society, Keynote Speaker
Myrtle Beach, SC
topic: cardiovascular complications of sleep apnea
2005 Vascular Biology Conference, Visiting Professor and invited lecturer
University of Alabama, Birmingham, Alabama
topic: cardiovascular complications of sleep apnea
2005 Pulmonary Grand Rounds
Mt. Sinai Hospital, New York, NY
topic: sleep apnea pathogenesis
2006 Society of Critical Care Medicine, invited lecturer
San Francisco, CA
topic: post-extubation failure
2006 Surgery Sleep and Breathing Meeting, invited lecturer
Chicago, IL
topic: upper airway mechanics and the evidence for CPAP
2006 Sleep 2006, invited lecturer 
Salt Lake City, UT
topic: year in review
2006- National Sleep Medicine Course, invited lecturer (2 lectures)
Chicago, IL
topic: sleep apnea
2006- Annual Sleep Board Review,  invited lecturer
(speaker ranked highest for content and presentation several times)
American College of Chest Physicians
Orlando, FLA or Phoenix, AZ
topics: obstructive and central sleep apnea
2006 92nd American College of Surgeons meeting, invited  lecturer
Chicago, IL
topic: intensive insulin therapy
2007 Society of Critical Care Medicine, invited lecture (3 lectures) and co-chair for 2 sessions Orlando, FL
various critical care topics
2007 Scripps Clinic, Visiting Professor and invited lecturer
San Diego, CA
topic: sleep apnea pathogenesis
2007 National Sleep Medicine Course, Meeting Chairman/Organizer and invited lecturer
(2 lectures)
Denver, CO
topic: sleep apnea
2007 American College of Chest Physicians (ACCP) Sleep Board Review, invited lecturer
(2 lectures)
Phoenix, AZ
topics: sleep apnea epidemiology and sleep apnea treatment
2007 Medical Grand Rounds
St. Luke’s Hospital, NY, NY
topic: future of sleep apnea treatment and cardiovascular complications of sleep apnea
2007 Sleep Apnea Board Review, ACCP Meeting, invited lecturer
Chicago, IL
topic: sleep apnea, obstructive and central, and board review
2007 Visiting Professor
Mayo Clinic, Rochester, MN
topic: controversies in critical care
2008 Medical Grand Rounds
Pennsylvania State University, Hershey, PA
topic: cardiovascular complications of sleep apnea
2008 Pulmonary Grand Rounds
Columbia University, NY, NY
topic: cardiovascular complications of sleep apnea
2008 Ohio Siesta meeting (ranked best speaker)
Kent State University, OH
topics: complex apnea and cardiovascular complications of apnea
2008 Medical Grand Rounds
Stamford Hospital, Stamford, CT
topic: cardiovascular complications of apnea
2008 American College of Chest Physicians Board Review, invited lecturer (2 lectures)
Orlando, FL
topic: sleep apnea
2008 American Academy of Dental Sleep Medicine, invited lecturer (2 lectures)
Baltimore, MD
topic: sleep apnea
2008 Sleep Society of Atlanta, GA, Keynote address
topic: sleep apnea
2008 American College of Chest Physicians Board Review, invited lecturer (2 lectures)
Orlando, FL
topic: sleep apnea
2008 National Sleep Medicine Course, invited lecturer
Chicago, IL
topic: central sleep apnea
2008 Critical Care Department, Mayo Clinic, Visiting Professor
Rochester, MN
topic: controversies in critical care
2008 Geriatrics & Biological Sciences Department, Univ. of Wisconsin, Visiting Professor  Madison, WI
topic: aging and sleep apnea
2008 Grand Rounds, Scripps Clinic, Visiting Professor
San Diego, CA
topic: cardiovascular complications of sleep apnea
2008 American Association of Respiratory Care meeting, invited lecturer (3 lectures)
Anaheim, CA
various topics in sleep medicine
2009 Society of Critical Care Medicine meeting, invited lecturer and 2 professor walk-round sessions
Nashville, TN
topic:  non-invasive ventilation
2009 American Association of Sleep Technologists (AAST), invited lecturer (2 lectures and a discussion section)
Cincinnati, OH
topic: sleep apnea
2009 American Thoracic Society, invited lecturer and session chair (4 lectures)
San Diego, CA
Various pulmonary/critical care and sleep topics
2009 Associated Professional Sleep Societies meeting, invited lecturer and and chair for 2 sessions
Seattle, WA
topic: sleep apnea
2009 American College of Chest Physicians Board Review, invited lecturer (2 lectures)
Phoenix, AZ
topic: sleep apnea
2009 Sleep Medicine Grand Rounds and Fellows’ Lecture
Stanford University, Stanford, CA
topics: sleep apnea pathogenesis and cardiovascular complications of sleep apnea
2009 New Jersey Sleep Society Annual Education Symposium, invited lecturer
New Brunswick, NJ
topic: complex sleep apnea
2009 Sleep Grand Rounds
University of Pittsburgh Medical Center, Pittsburgh, PA
topic: future of sleep apnea therapy
2009 Pulmonary Grand Rounds
Ohio State University, Columbus, OH
topic: controversies in critical care

2009 American Association of Respiratory Care meeting
San Antonio, TX
topic: central sleep apnea
2010 American Academy of Dental Sleep Medicine, Webinar leader
topic: sleep apnea
2010 Pulmonary Grand Rounds
University of Miami, Miami, FL
topic: future of sleep apnea therapy
2010 Case Western Reserve University, invited lecturer (2 lectures)
Cleveland, OH
topics: sleep and critical care sleep apnea and ARDS
2010 Wayne State University, Visiting Professor and invited lecturer (2 lectures)
Detroit, MI
various pulmonary/critical care and sleep topics
2010 Tennessee Sleep Society meeting, Keynote Speaker
Nashville, TN
topic: sleep apnea
2010 American College of Chest Physicians Board Review, invited lecturer (2 lectures)
Orlando, FL
topic: sleep apnea
2010 8th Annual Northern New England Critical Care Conference, Keynote Speaker Burlington, VT
topic: controversies in critical care
2010 National Heart Lung and Blood Institute workshop: Molecular Mechanisms Underlying Sleep Apnea, invited lecturer (3 lectures)
Bethesda, MD
topic: sleep apnea mechanisms
2010-11 Sleep State of the Art Course, American Thoracic Society, invited lecturer
(~3-4 lectures per annual course)
Miami, FL, or San Diego, CA
various topics in sleep apnea
2011   American Academy of Facial Pain meeting, Featured Speaker
New Orleans, LA
topic: sleep apnea
2011 Pulmonary Grand Rounds, University of California at San Diego, San Diego, CA
topic: future of sleep apnea therapy
2011 New York State Thoracic Society meeting, invited speaker
NY, NY
topic: sleep apnea
2011 Pulmonary & Critical Care Grand Rounds, Univ. of Wisconsin, Visiting Professor Madison, WI
topic: sleep apnea and mechanical ventilation
2011 University of Wisconsin Veterinary School, Visiting Professor and invited Neuroscience lecturer
Madison, WI
topics: sleep apnea and mechanical ventilation
2011 Associated Professional Sleep Societies meeting, invited lecturer and session co-chair Minneapolis, MN
topic: sleep apnea  
2011 Stanford University, invited lecturer and Visiting Professor
Palo Alto, CA
topic: sleep apnea mechanisms
2011 American College of Chest Physicians Board Review, invited lecturer (2 lectures)
San Antonio, TX
topic: sleep apnea
2011 American Association of Oral and Maxillofacial Surgeons, invited lecturer
Chicago, IL
topic: sleep apnea biomarkers
2011 Society of Anesthesia and Sleep Medicine (SASM) inaugural meeting, Keynote Speaker
Chicago, IL
topic: future research priorities for anesthesia and sleep medicine
   
2011 Pulmonary and Critical Care Grand Rounds
Stanford University, Palo Alto, CA
topic: controversies in critical care
2011 Sleep Summit, invited lecturer
Las Vegas, NV
topic: sleep apnea therapy
2011 Pulmonary Grand Rounds
Dartmouth-Hitchcock Medical Center, Hanover, NH
topic: future of sleep apnea therapy
2011 Critical Care Grand Rounds
Dartmouth-Hitchcock Medical Center, Hanover, NH
topic: controversies in critical care
2012 Seattle Sleep Medicine and Technology Program, invited lecturer
Seattle, WA
topic: sleep apnea therapy
2012 Pulmonary Fellows’ Teaching Conference, invited lecturer
University of Washington, Seattle, WA
topic: sleep apnea
2012 Carolinas 2nd Annual Sleep Symposium
Charlotte, NC
topic: sleep apnea therapy
2012 18th annual Advances in Diagnosis and Treatment of Sleep Apnea and Snoring meeting, invited lecturer (3 lectures)
University of California at San Francisco, San Francisco, CA
topic: sleep apnea
2012 University of California, San Diego, CA
Invited lecture for special seminar
topic: sleep apnea
2012 Case Western Reserve University, Cleveland, Ohio
Invited lecture Pulmonary and Critical Care Grand Rounds
topic: sleep apnea
2012 American Academy of Otolaryngology, invited lecturer
Washington, DC
topic: sleep apnea mechanisms
2012 University of California, San Diego, CA
Pulmonary and Critical Care Grand Rounds
Topic: critical care controversies
2012 University of Pennsylvania, Philadelphia, PA
Invited lecture
Topic: sleep apnea
2012 Society of Anesthesia and Sleep Medicine, invited lecturer and session chair
Washington, DC
topic: peri-operative complications of sleep apnea
2013 Tiger 21, invited lecture and panel discussion
Group of high net worth investors meeting to discuss investments and personal health
Palm Beach, Florida
topic: sleep deprivation and human performance
  International   

Year(s)
Title of presentation or name of course/ Type of presentation/role(s) (note if presentation the result of a selected abstract)
Location (Sponsor, if any)
2001 McGill University, Visiting Professor
Montreal, Quebec
topic: sleep apnea pathogenesis
2003 Upper Airway Physiology Meeting, invited speaker
University of Melbourne, Melbourne, Australia
Topic: upper airway pharmacology
2003 Physiology Conference, invited speaker
Alfred Hospital, Victoria, Australia
Topic: upper airway reflexes
2004 Ross University, invited speaker
Dominica, West Indies
topic: upper airway physiology
2004 Chiba University, invited speaker
Chiba, Japan
topic: upper airway physiology
2004 Sleep Apnea Meeting, Keynote Speaker
Tokyo, Japan
topic: sleep apnea complications
2005 University of Toronto, Visiting Professor
Ontario, Canada
topic: sleep apnea pathogenesis
2005 University of Calgary, Visiting Professor
Alberta, Canada
topic: future of sleep apnea treatment/ upper airway physiology
2005 Continuous Positive Airway Pressure (CPAP) Annual Conference, Keynote Speaker Nagoya, Japan
topic: cardiovascular complications of apnea
2007 University of British Columbia, invited speaker
Vancouver, British Columbia, Canada
topic: finite element analysis in the upper airway
2007 Vancouver General Hospital, Visiting Professor
Vancouver, Canada
topic: future of sleep apnea treatment
2007 Upper Airway Symposium, invited speaker
Perth, Australia
topic: brain stem reflexes in OSA
2007 Pulmonary Grand Rounds, invited speaker
Royal Brompton Hospital, London, UK
topic: future of sleep apnea treatment/
2007 Pulmonary Board Review, invited speaker
San Juan, Puerto Rico
Topic: various pulmonary, critical care, sleep board review questions
2007 Chilean Thoracic Society, Keynote Speaker,  invited lecturer (4 lectures)
Santiago, Chile
various sleep science topics
2007 Critical Care Research Day, Visiting Professor
McGill University, Montreal, Quebec
topic: controversies in critical care
2007 International Sleep and Breathing meeting, invited lecturer and discussion leader
Palm Cove, Queensland, Australia
topic: brainstem reflexes in OSAs
2007 British Sleep Society, Keynote Address
Cambridge, UK
topic: future of sleep apnea treatment
2008 Harvard Medical School Dubai Center International, invited lecturer (4 lectures)
Dubai, United Arab Emirates
various critical care topics
2009 Israeli Sleep Society, Keynote speaker (postponed due to war)
Haifa, Israel
topic: sleep apnea pathogenesis
2009 World Congress on Sleep Apnea, invited speaker and discussion leader
Seoul, South Korea
topic: arousal threshold in sleep apnea
2010 Upper Airway meeting, invited lecturer
Port Stephens, New South Wales, Australia
topic: pharmacology of sleep apnea
2010 Ranbaxy Foundation, Visiting Professor and Keynote Speaker
New Delhi, India
various sleep apnea topics
2010 Patel Chest Institute, invited lecturer
New Delhi, India
topic: sleep apnea
2010 All India Institute of Medical Sciences (AIIMS), Visiting Professor
New Delhi, India
topic: sleep apnea
2011 International Sleep & Breathing Meeting, session chair,
Barcelona, Spain
2011 University of Alberta, invited lecture and Visiting Professor
Edmonton, Alberta, Canada
topic: future of sleep apnea therapy
2011 University of Grenoble, invited lecturer and Visiting Professor
Grenoble, France
topic: therapy of OSA in the future
2011 University of Manitoba, invited lecturer and Visiting Professor
Canada
topic: therapy for OSA using a mechanistic approach
2011 Instituto de Sono, invited lecturer
Sao Paulo, Brazil
topic: sleep apnea
2011 University of Sao Paulo, Visiting Professor
Sao Paulo, Brazil
topic: sleep apnea
2011 Federal University of Sao Paulo, invited lecturer and Visiting Professor
Sao Paulo, Brazil
Cardiovascular Complications of Sleep Apnea
2012 King Faisal Hospital, attending physician and invited lecturer
Kigali, Rwanda
various critical care topics
2012 Toronto Critical Care Symposium
Toronto, Ontario, Canada
topics: mechanical ventilation, upper airway mechanics
2013 American College of Physicians Puerto Rico
San Juan, Puerto Rico
topic: sleep apnea
2013 University of Toronto
Medical Grand Rounds
topic: sleep apnea

Report of Clinical Activities and Innovations
Current Licensure and Certification

Year
Type of License or Certification
1996 Massachusetts License
1996 American Board of Internal Medicine
1997 Fellow Royal College of Physicians of Canada (FRCPC)
1998 American Board of Medical Specialties: Pulmonary Disease
1999 American Board of Medical Specialties: Critical Care Medicine
2000 Royal College of Physicians of Canada, Special Certification in Respirology
2007 American Board of Medical Specialties: Sleep Medicine
Practice Activities My practice activities involve outpatient and inpatient work related to pulmonary, critical care and sleep medicine.  My work involves seeing patients, overseeing fellows, and leading the clinical Sleep Program at BWH.  Over the past 10 years, I have also had attending/teaching responsibilities in the ICUs at BWH, MGH and BIDMC.  This work involves directing rounds with a team of trainees including fellows, residents, interns, medical students, nurses, pharmacists and respiratory therapists.  In 2012, I attended in the ICU of King Faysal Hospital in Kigali, Rwanda.  I have also overseen the pulmonary fellows in outpatient clinics and seen patients in the Center for Chest Disease at the Brigham.   
1999-2000 Intensive Care Unit, Medical and Surgical West Roxbury VA Medical Center One month per year
2000-2002 Surgical Intensive Care Unit Brigham and Women’s Hospital 6-8 weeks per year
2000-2003 Interstitial Lung Disease Clinic Brigham and Women’s Hospital One half day per week
2000- Medical Intensive Care Unit Massachusetts General Hospital 0-8 weeks per year
2005- Medical Intensive Care Unit Beth Israel Deaconess Medical Center 0-8 weeks per year
2006- Sleep Medicine Clinic Brigham and Women’s Hospital 1-2 half days per week
2006- Polysomnography Interpretations Brigham and Women’s Hospital 1 half day per week
2012- Surgical Intensive Care Unit King Faysal Hospital, Kigali, Rwanda 24/7 coverage for 2 weeks

Clinical Innovations 2003-present I have implemented our ACGME clinical sleep fellowship to allow for the effective oversight of medical education as well as patient care.  This process required a restructuring of our clinics to allow for our sleep trainees to receive excellent teaching as well as patient care experience.  I have also adapted our clinical sleep program to the changing times such that clinical care pathways are altered based on new technology, changes in reimbursement, or evolving data regarding best available evidence.  For example, home sleep testing was essentially unavailable five years ago, but now is the standard of care for many of our sleep apnea patients. Over this time, we have also developed programs to screen for high risk patients including people with heart failure, type 2 diabetes mellitus, and bariatric surgery patients among others.  These innovations were recognized when the Brigham and Women’s was awarded an Academic Program of Distinction by the American Academy of Sleep Medicine (co-directors Czeisler and Malhotra).  Our clinical care model has been incorporated into clinical practice guidelines which are now being implemented around the world.

Report of Education of Patients and Service to the Community
Educational Materials for Patients and the Lay Community No materials below were sponsored by outside entities. There are numerous articles,  interviews, and information products in the national and global popular media (on-line, in print, broadcast news, etc.) related to my work or for which I have served as a contributor, including: 1. Kowalczyk L. “You don’t snooze, you lose.”  Boston Globe, July 20, 2009. Available at http://www.boston.com/news/health/articles/2009/07/20/dr_atul_malhotra_discusses_sleep_disorders/ 2. Radio interviews, including National Public Radio (US) and Winnipeg (Canada) stations 3. TV interviews, including New England Cable News (NECN) 4. Apnea: Understanding and Treating Obstructive Sleep Apnea. The Apnea Website. Launched April 1, 2011. Produced by the Harvard Medical School Division of Sleep Medicine and WGBH Educational Foundation. (The overall goal of this project is to translate medical and scientific research on sleep in a way that makes it accessible and useful to the general audience.) 5. Shaq Attacks Sleep Apnea. YouTube video featuring basketball star Shaquille O’Neal, in which I am interviewed. Posted May 5, 2011. Available at http://www.youtube.com/ watch?v=4JkiWvWn2aU. (O’Neal has been a Sleep Medicine patient at BWH.) 6. Trinder J, Malhotra A. “Sleep Apnea.” Scholarpedia. Available at http://www.scholarpedia.org/article/Sleep_apnea 7. Boston Globe.com August 19, 2012 “Aging baby boomers, who once neglected their sleep, are now finding it harder to come by”, interview with Atul Malhotra

Recognition
1984-88 Certificate of Appreciation for volunteer work Grandview Extended Care Center, Edmonton, Canada Outstanding contribution

Report of Scholarship
Publications
Include only manuscripts that are published or accepted for publication (forthcoming) in print or other media; do not include manuscripts that have been submitted but not accepted for publication or those that are in preparation; Please use bold-faced type for your name in the authorship list. Numbering of contributions should start with "1" in each new section.
Peer reviewed publications in print or other media
Group peer reviewed publications in three categories under the following headings:
-Research investigations
-Other peer-reviewed publications (e.g., case reports, proceedings of meetings which are full-length manuscripts)
-Research publications without named authorship 
Research Investigations
  • Schwartz D, Maroo A, Malhotra A, Kesselman H.  Negative pressure pulmonary hemorrhage.  Chest 1999; 115(4): 1194-8. PMID: 10208229.
  • Fogel RB, Malhotra A, Shea SA, Edwards JK, White DP.  Reduced genioglossal activity with upper airway anesthesia in awake patients with OSA.  J Appl Physiol 2000; 88(4):1346-54. PMID: 10749829.
  • Malhotra A, Fogel R, Edwards J, Shea SA, White DP. Local mechanisms drive pharyngeal muscle dilator activation in obstructive sleep apnea. Am J Respir Crit Care Med 2000; 161(5):1746-9. PMID: 10806181.
  • Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards JK, Slamowitz DI, Shea SA, White DP. Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure. Am J Respir Crit Care Med 2000; 162(3): 1058-62. PMID: 10988130.
  • Pillar G, Malhotra A, Fogel R, Beauregard J, Schnall R, White DP.  Airway mechanics and ventilation in response to resistive loading during sleep: influence of gender. Am J Respir Crit Care Med 2000; 162(5):1627-32. PMID: 11069787.
  • Pillar G, Malhotra A, Fogel, R, Beauregard J, Slamowitz, D, Shea SA and White DP.  Upper airway muscle responsiveness to rising PCO2 during NREM Sleep.  J Appl Physiol 2000; 89(4): 1275-82. PMID: 11007559.
  • Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP.  Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.  J Clin Endocrinol Metab 2001; 86(3):1175-80. PMID: 11238505.
  • Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards JK, White DP. Upper airway collapsibility: measurements and sleep effects.  Chest 2001; 120(1):156-61. PMID: 11451832.
  • Pillar G, Fogel R, Malhotra A, Beauregard J, Edwards JK, Shea SA, White DP.  Genioglossal inspiratory activation: central respiratory versus mechanoreceptive influences.  Respir Physiol 2001; 127(1):  23-38. PMID: 11445198.
  • Hilton MF, Chappell MJ, Bartlett WA, Malhotra A, Beattie JM, Cayton RM.  The sleep apnoea/hypopnoea syndrome depresses waking vagal tone independent of sympathetic activation.  Eur Respir J 2001; 17(6): 1258-66. PMID: 11491174.
  • Fogel RB, Malhotra A, Pillar G, Edwards JK, Beauregard J, Shea SA, White DP.  Genioglossal activation in patients with obstructive sleep apnea versus controls: mechanisms of muscle control. Am J Respir Crit Care Med 2001; 164(11): 2025-30. PMID: 11739130.
  • Malhotra A, Pillar G, Fogel R, Edwards J, Ayas N, Akahoshi T, Hess D, White DP.  Pharyngeal pressure and flow effects on genioglossus activation in normal subjects Am J Respir Crit Care Med 2002; 165(1):71-7. PMID: 11779733.
  • Fisher D, Pillar G, Malhotra A, Peled N, Lavie P.  Long-term follow-up of untreated patients with sleep apnea syndrome.  Respir Med 2002; 96(5): 337-43. PMID: 12113384.
  • Stanchina M, Malhotra A, Fogel R, Ayas, N, Edwards JK, Schory K, White DP.  Genioglossal muscle responsiveness to chemical and mechanical loading during non-rapid eye movement sleep.  Am J Respir Crit Care Med 2002; 165(7): 945-9. PMID: 11934719.
  • Karmpaliotis D, Kosmidou I, Ingenito EP, Hong K, Malhotra A, Sunday ME, Haley KJ.  Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury.  Am J Physiol Lung Cell Mol Physiol 2002; 283(3): L585-95. PMID: 12169578.
  • Snow A, Gozal E, Malhotra A, Tiosano D, Perlman R, Vega C, Shahar E, Gozal D, Hochberg Z, Pillar G.  Severe hypersomnolence after pituitary/hypothalamic surgery in adolescents: clinical characteristics and potential mechanisms. Pediatrics 2002; 110(6): e74. PMID: 12456941.
  • Malhotra A, Huang Y, Fogel RB, Pillar G, Edwards JK, Kikinis R, Loring SH, White DP.  The male predisposition to pharyngeal collapse:  importance of airway length.  Am J Respir Crit Care Med 2002; 166(10):1388-95. PMID: 12421747.
  • Wellman A, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP.  Respiratory system loop gain in normal men and women measured with proportional-assist ventilation. J Appl Physiol 2003; 94(1):205-12. PMID: 12391042.
  • Ayas N, White DP, Manson JE, Stampfer MJ, Speizer FE, Malhotra A, Hu F.  A prospective study of sleep duration and coronary heart disease in women.  Arch Intern Med 2003; 163(2): 205-9. PMID: 12546611.
  • Pillar G, Schuscheim G, Weiss R, Malhotra A, McCowen KC, Shlitner A, Peled N, Shehadeh N.  Interactions between hypoglycemia and sleep architecture in children with type 1 diabetes mellitus. J Pediatr 2003; 142(2):163-8. PMID: 12584538.
  • Patel SR, White DP, Malhotra A, Stanchina ML, Ayas NT.  Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis.  Arch Intern Med 2003;163(5): 565-71. PMID: 12622603.
  • Berry RB, White DP, Roper J, Pillar G, Fogel RB, Stanchina M, Malhotra A.  Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects.  J Appl Physiol 2003; 94(5): 1875-82. PMID: 12533492.
  • Malhotra A, Muse V, Mark E.  Case records of the Massachusetts General Hospital.  Weekly clinicopathological exercise Case 12-2003: An 82-year-old man with dyspnea and pulmonary abnormalities.  New Engl J Med 2003; 348(16): 1574-85. PMID: 12700378.
  • Fogel RB, Trinder J, Malhotra A, Stanchina M, Edwards JK, Schory KE, White DP.  Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state.  J Physiol (Lond) 2003; 550(3):899-910. PMID: 12807995 PMCID: 2343065.
  • Stanchina ML, Malhotra A, Fogel RB, Trinder J, Edwards JK, Schory K, White, DP.  The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep.  Sleep 2003; 26(7):851-6.  PMID: 14655919.
  • Fogel R, White DP, Pierce R, Malhotra A, Edwards J, Dunai J, Kleverlaan D, Trinder J.  Control of upper airway muscle activity in younger versus older men during sleep onset.  J Physiol (Lond) 2003; 553(2): 533-44. PMID: 12963804 PMCID: PMC2343562.
  • Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP.  Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis.  Sleep 2004; 27(2): 249-53. PMID: 15124718.
  • Patel SR, Karmpaliotis D, Ayas NT, Mark EJ, Wain J, Thompson BT, Malhotra A.  The role of open-lung biopsy in ARDS. Chest 2004; 125(1):197-202. PMID: 14718441.
  • Pittman SD, Ayas NT, MacDonald MM, Malhotra A, Fogel RB, White DP.  Using a wrist-worn device based on peripheral arterial tonometry to diagnose obstructive sleep apnea: in-laboratory and ambulatory validation.  Sleep 2004; 27(5):923-33. PMID: 15453551.
  • Malhotra A, Trinder J, Fogel R, Stanchina M, Patel SR, Schory K, Kleverlaan D, White DP.  Postural effects on pharyngeal protective reflex mechanisms. Sleep 2004; 27(6):1105-12. PMID: 15532204.
  • Jordan AS, McEvoy RD, Edwards JK, Schory K, Yang C-K, Catcheside PG, Fogel RB, Malhotra A, White DP.  The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans. J Physiol (Lond) 2004; 558(3): 993-1004. PMID: 15218069 PMCID: PMC1665031.
  • Pittman SD, MacDonald MM, Fogel RB, Malhotra A, Todros K, Levy B, Geva AB, White DP. Assessment of automated scoring of polysomnographic recordings in a population with suspected sleep-disordered breathing.  Sleep 2004; 27(7): 1394-403. PMID: 15586793.
  • Wellman A, Jordan AS, Malhotra A, Fogel RB, Katz ES, Schory K, Edwards JK, White DP. Ventilatory control and airway anatomy in obstructive sleep apnea.  Am J Respir Crit Care Med 2004; 170(11): 1225-32. PMID: 15317668.
  • Jordan AS, Wellman DA, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP.  Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea.  J Appl Physiol 2005; 99(5): 2020-7. PMID: 15994243.
  • Fogel RB, Trinder J, White DP, Malhotra A, Raneri J, Schory K, Kleverlaan D, Pierce RJ.  The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls. J Physiol (Lond) 2005; 564(2):549-62. PMID: 15695240 PMCID: PMC1464430.
  • Aloia MS, Stanchina M, Arnedt JT, Malhotra A, Millman RP.  Treatment adherence and outcomes in flexible vs. standard continuous positive airway pressure therapy. Chest 2005; 127(6):2085-93. PMID: 15947324 PMCID: PMC2287195.
  • Bajwa EK, Ayas NT, Schulzer M, Mak E, Ryu JH, Malhotra A.  Interferon-gamma 1b therapy in idiopathic pulmonary fibrosis:  a meta-analysis.  Chest 2005; 128:203-6. PMID: 16002936
  • Huang Y, White DP, Malhotra A.  The impact of anatomic manipulations on pharyngeal collapse: results from a computational model of the normal human upper airway.  Chest 2005; 128(3):1324-30. PMID: PMC16162725.
  • Caramez MP, Borges JB, Tucci MR, Okamoto VN, Carvalho CRR, Kacmarek RM, Malhotra A, Velasco IT, Amato MB.  Paradoxical responses to positive end-expiratory pressure in patients with airway obstructive during controlled ventilation.  Crit Care Med 2005; 33(7):1519-28. PMID: 16003057 PMCID: PMC2287196.
  • Heinzer RC, Stanchina ML, Malhotra A, Fogel RB, Patel SR, Jordan A, Schory K, White DP.  Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea.  Am J Respir Crit Care Med 2005; 172(1):114-7. PMID: 15817803. PMCID: 2718445.
  • Huang Y, Malhotra A, White DP.  Computational simulation of human upper airway collapse using a pressure -/state-dependent model of genioglossal muscle contraction under laminar flow conditions.   J Appl Physiol 2005; 99(3):1138-48. PMID: 1138-1148.
  • Yinon D, Lowenstein L, Suraya S, Belooseski R, Zmora O, Malhotra A, Pillar G.  Pre-eclampsia is associated with sleep disordered breathing and endothelial dysfunction.  Eur Respir J 2006; 27(2):328-33. PMID: 16452588.
  • Malhotra A, Huang Y, Fogel R, Lazic S, Pillar G, Jakab M, Kikinis R, White DP.  Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse. Am J Med 2006; 119(1): 72 e9-14. PMID: 16431197. PMCID: 2287192.
  • Pittman SD, Pillar G, Berry R, Malhotra A, MacDonald MM, White DP.  Follow-up assessment of CPAP efficacy in patients with obstructive sleep apnea using an ambulatory device based on peripheral arterial tonometry.  Sleep and Breathing 2006; 10(3): 123-131. PMID: 16586136.
  • Talmor D, Sarge T, O’Donnell CR, Ritz R, Malhotra A, Lisbon A, Loring SH.  Esophageal and transpulmonary pressures in acute respiratory failure.  Crit Care Med 2006; 34(5):1389-94. PMID: 16540960. PMCID: 2278169.  (invited editorial)
  • Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RC, Schory K, Dover L, Fogel RB, White DP. Genioglossal muscle response to CO2 stimulation during NREM sleep. Sleep 2006; 29(4):470-7. PMID: 16676780.
  • Caramez MP, Schettino G, Suchodolski K, Nishida T, Harris RS, Malhotra A, Kacmarek RM. The impact of endotracheal suctioning on gas exchange and hemodynamics during lung protective ventilation in acute respiratory distress syndrome.  Respir Care 2006; 51(5):497-502. PMID: 16638159.
  • Cho M, Malhotra A, Karmpoliotis D, Harris RS, Wain J, Patel SR.  Mechanical ventilation and air leaks after lung biopsy for acute respiratory distress syndrome.  Ann Thorac Surg 2006; 82(1): 261-266. PMID: 16798226.
  • Heinzer R, Stanchina M, Malhotra A, Jordan AS, Patel SR, Lo Y, Wellman A, Schory K, Dover L, White DP.  Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea. Thorax 2006; 61(5):435-9. PMID: 16490766.  PMCID: 2111199.
  • Patel SR, Malhotra A, Gottlieb D, White DP, Hu FB.  Correlates of long sleep duration.  Sleep 2006; 29(7): 881-889. PMID: 16895254.
  • Patel SR, Malhotra A, White DP, Gottlieb D, Hu FB.  Association between reduced sleep and weight gain in women.  Am J Epi 2006; 164(10): 947-954. PMID: 16914506.
  • Nguyen TN, Badjatia N, Malhotra A, Gibbons F, Qureshi MM, Greenberg SA.  Factors predicting extubation success in patients with Guillain-Barré syndrome.  Neurocrit Care. 2006; 5(3): 230-4. PMID: 17290095.
  • Karmpaliotis D., Kirtane AJ, Ruisi C, Polonsky T, Malhotra A, Talmor D, Kosmidou I, Jarolim P, de Lemos JA, Sabatine MS, Gibson CM, Morrow D.  Diagnostic and prognostic utility of Brain Natriuretic Peptide in subjects admitted to the intensive care unit with hypoxic respiratory failure due to non-cardiogenic and cardiogenic pulmonary edema. Chest 2007; 131(4): 964-971. PMID: 17426196. PMCID: 2278171.
  • Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP.  Chemical control stability in the elderly.  J Physiol (Lond) 2007; 581(1): 291-8. PMID: 17317747. PMCID: 2075232.
  • Ronen O, Malhotra A, Pillar G.  The influence of gender and age on upper airway length during development.  Pediatrics 2007; 120(4): e1028-34. PMID: 17908723 PMCID: 2278168.  
  • Eikermann M, Jordan AS, Chamberlin NL, Gautam S, Wellman DA, Lo Y, White DP and Malhotra A. The Influence of aging on pharyngeal collapsibility during sleep, Chest 2007; 131(6): 1702-1709. PMID: 17413053. PMCID: 2278166.
  • Huang Y, White DP, Malhotra A. Use of computational modeling to predict responses to upper airway surgery in obstructive sleep apnea. Laryngoscope. 2007; 117(4): 648-653. PMID: 17415135.
  • Chamberlin NL, Eikermann M, Fassbender P, White DP, and Malhotra A. Genioglossus premotoneurons and the negative pressure reflex in rats. J Physiol (Lond) 2007; 579(2): 515-26. PMID: 17185342. PMCID: 2075396.
  • Lo Y, Jordan A, Malhotra A, Wellman A, Heinzer R, Eikermann M, Schory K, Dover L, White DP.  The influence of wakefulness on pharyngeal airway muscle activity. Thorax 2007; 62(9): 799-805. PMID: 17389755. PMCID: 2117303.  
  • Jordan AS, Wellman DA, Heinzer R, Lo Y, Schory K, Dover L, Gautam S, Malhotra A and White DP.  Mechanisms used to restore ventilation  after partial upper airway collapse during sleep in humans.  Thorax 2007; 62(10): 861-867. PMID: 17412778. PMCID: 2094262.
  • Pierce R, White DP, Malhotra A, Edwards J, Kleverlaan D, Palmer LJ, Trinder J.  Upper airway collapsibility, dilator muscle activation and resistance in sleep apnoea. Eur Respir J 2007; 30(2): 345-53. PMID: 17459896.
  • Stanchina ML, Ellison K, Malhotra A, Anderson M, Kirk M, Benser ME, Tosi C, Carlisle C, Millman RP, Buxton A.  The impact of cardiac resynchronization therapy on obstructive sleep apnea in heart failure patients: a pilot study. Chest 2007; 132(2): 433-439. PMID: 17573498. PMCID: 2287194.  
  • Eikermann M, Fassbender P, Malhotra A Takahashi M, Kubo S, Jordan AS, White DP, and Chamberlin NL.  Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function. Anesthesiology 2007; 107(4): 621-629. PMID: 17893459.
  • Talmor D, Sarge T, Legedza DA, O’Donnell CR, Ritz R, Loring SH, Malhotra A.  Cytokine release following recruitment maneuvers. Chest 2007; 132(5): 1434-1439. PMID: 17925413. PMCID: 2628458.
  • Caramez MP, Miyoski E, Harris RS,  Kacmarek R, Malhotra A.  Gas exchange impairment induced by open suctioning in ARDS: Impact of permissive hypercapnia. Crit Care Med 2008; 36(2): 560-564. PMID: 18091534.
  • Eikermann M, Malhotra A, Fassbender P, Zaremba S, Jordan AS, White DP, Chamberlin N. Differential effects of isoflurane and propofol on upper airway dilator muscle activity and breathing.  Anesthesiology 2008;108(5): 897-906. PMID: 18431126.
  • Macdonald M, Fang J, Pittman S, White DP, Malhotra A.  The current prevalence of sleep disordered breathing in congestive heart failure patients treated with beta blockers. J Clin Sleep Med 2008; 4(1):38-42. (invited editorial) PMID: 18350960. PMCID: 2276820.
  • Heinzer R, White DP, Malhotra A, Lo Y, Dover L, Stevenson K, Jordan A.  Effect of expiratory positive airway pressure on sleep disordered breathing. Sleep 2008; 31(3):429-32. PMID: 18363320. PMCID: 2276743.
  • Wilkinson V, Malhotra A, Nicholas CL, Worsnop C, Jordan AS, Butler JE, Saboisky JP, Gandevia SC, White DP, Trinder J.  Discharge patterns of human genioglossus motor units during sleep onset. Sleep 2008; 31(4): 525-533. PMID: 18457240. PMCID: 2279758.
  • Jia S, Malhotra A, Saeed M, Mark R, Talmor D.  Risk factors for acute respiratory distress syndrome in patients mechanically ventilated.  Chest 2008; 133(4): 853-61. PMID: 18263691. PMCID: 2628459.
  • Heinzer R, White DP, Jordan AS, Lo Y, Dover L, Stevenson K, Malhotra A.  Trazodone increases arousal threshold in obstructive sleep apnoea.  Eur Respir J 2008; 31(6): 1308-1312. PMID: 18256066. PMCID: 2732198.
  • Segal Y, Malhotra A, Pillar G.  Upper airway length may be associated with the severity of obstructive sleep apnea syndrome. Sleep & Breathing 2008; 12(4):311-6.
  • Elinoff J, Talmor D, Subramanian B, Karmpaliotis D, Goldberger A, Malhotra A.  Effects of mechanical ventilation on the electrocardiogram in adults. Lung 2008; 186(4): 219-223. PMID: 18478291.
  • Eikermann M, Zaremba S, Malhotra A, Jordan AS, Rosow C, Chamberlin NL.  Neostigmine but not Sugaammadex impairs upper airway dilator muscle activity and breathing. Br J Anaesth 2008; 101(3):344-9. PMID: 18559352.
  • Owens R, Hess D, Venegas J, Malhotra A, Harris RS.  Effect of the chest wall on pressure-volume curve analysis of ARDS lungs.  Crit Care Med 2008; 36(11): 2980-5. PMID: 18824918.
  • Wellman A, Malhotra A, Jordan AS, Stevenson KE, Gautam S, White DP.  Effect of oxygen in obstructive sleep apnea: Role of loop gain.  Respir Physiol Neurobiol 2008; 31;162(2):144-51. PMID: 18577470.
  • Talmor D, Sarge T, Malhotra A, O’Donnell C, Ritz R, Loring SH.  Mechanical ventilation guided by esophageal pressure in acute lung injury.  New Engl J Med 2008; 359(20): 2095-2104. PMID: 19001507 (invited editorial)
  • Yim Yeh S, Doupis J, Rahangdale S, Horr S, Malhotra A, Veves A.  Total serum bilirubin does not affect vascular reactivity in patients with diabetes.  Vasc Med 2009; 14(2):129-136. PMID: 19366819. PMCID: 2729815
  • Eckert D, Malhotra A, Lo Y, White DP, Jordan AS. Genioglossus muscle activity during REM sleep on CPAP in men and women with and without obstructive sleep apnea.  Chest 2009; 135(4):957-64. PMID: 19118266
  • Jordan AS, White DP, Lo Y, Wellman A, Eckert DJ, Yim-Yeh S, Eikermann M, Smith SA, Stevenson KE, Malhotra A.  Airway dilator muscle activity and lung volume during stable breathing in OSA.  Sleep 2009; 32(3):361-368. PMID: 19294956, PMCID: PMC2647790
  • Caramez MP, Kacmarek RM, Helmy M, Miyoshi E, Malhotra A, Amato MB, Harris RS.  A comparison of methods to identify open-lung PEEP.  Intens Care Med 2009; 35(4):740-7. PMID 19183951
  • Griesdale D, de Souza R, van Dam R, Heyland DK, Cook D, Malhotra A, Dhaliwal R, Talmor D, Chittock D, Finfer S.  Intensive insulin therapy and mortality in the critically ill: A meta-Analysis updated with the NICE-SUGAR data.  Can Med Assoc J 2009; 180(8):821-7. PMID: 19318387. PMCID: PMC2665940 (with invited editorial)
  • Fassbender P, Geldner G, Blobner M, Hofmockel R, Rex C, Gautam S, Malhotra A, and Eikermann M.  Clinical predictors of duration of action of long-term administered Cisatracurium and Rocuronium. Am J Crit Care 2009; 18(5): 439-445. PMID 19723864.
  • Eikermann M, Fassbender P, Zaremba S, Jordan AS, Rosow C, Malhotra A, Chamberlin NL.  Pentobarbital Dose-dependently Increases Respiratory Genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats. Anesthesiology 2009; 110(6): 1327-1334. PMID 19417601.
  • Wiznitzer A, Mayer A, Novack V, Sheiner E, Gilutz H, Malhotra A, Novack L.  Association of lipid levels during gestation with pre-eclampsia and gestational diabetes mellitus: a population-based study. Am J Obstet Gynecol 2009; 201: 482 e1-9. PMID: 19631920.
  • Buckley J, Addrizzo-Harris DJ, Clay AS, Curtis JR, Kotloff RM, Lorin SM, Murin S, Sessler CN, Rogers PL, Rosen MJ, Spevetz A, King TE,  Malhotra A, Parsons P. Multi-society task force recommendations of competencies in pulmonary and critical care medicine. Am J Respir Crit Care Med 2009; 180: 290-295. PMID: 19661252.
  • Wilkinson V, Malhotra A, Jordan AS, Worsnop C, Nicholas C, Saboisky J, Butler J, Gandevia S, White DP, Trinder J. Discharge patterns of human genioglossus motor units during arousal from sleep. Sleep 2010; 33(3): 379-387. PMID 20337197. PMCID: PMC2831433.
  • Owens R, Malhotra A, Eckert D, White DP, Jordan A, The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility. J Appl Physiol 2010; 108(2):445-51. PMID: 19940097.
  • Loring SH, O’donnell C, Behazin N, Malhotra A, Sarge T, Ritz R, Talmor, D. Esophageal pressures in acute lung injury – do they represent artifact or useful information about transpulmonary pressure, chest wall mechanics and lung stress. J Appl Physiol 2010; 108(3): 515-522. PMID: 20019160. PMCID: PMC2838644.
  • Eikermann M, Eckert DJ, Chamberlin NL, Jordan AS,  Zaremba S, Smith S, Rosow C, Malhotra A. Effects of pentobarbital on upper airway patency during sleep. Eur Respir J 2010; 36(3):569-76. PMID: 20032012
  • Kezirian E, Malhotra A, Goldberg A, White DP. Changes in OSA severity, biomarkers, and quality of life after multilevel surgery. Laryngoscope 2010; 120(7):1481-8. PMID: 20564750.
  • Krystal AD, Zammit GK, Wyatt JK, Quan SF, Edinger JD, White DP, Chiacchierini RP, Malhotra A. The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia. J Clin Sleep Med 2010; 6(4): 315-321. PMID 20726278. PMCID: PMC2919660.
  • Yim Yeh S, Rahangdale S, Nguyen A, Jordan AS, Novack V, Veves A, Malhotra A. Obstructive sleep apnea and aging effects on macrovascular and microcirculatory function. Sleep 2010; 33(9): 1177-1183. PMID 20857864. PMCID: PMC2938858
  • Campana L, Owens R, Clifford G, Pittman S, White DP, Malhotra A. Phase rectified signal averaging as a sensitive index of autonomic changes with aging.  J Appl Physiol 2010; 108(6): 1668-1673. PMID: 20339014. PMCID: PMC2886688
  • Eckert DJ, Saboisky JP, Jordan AS, White DP, Malhotra A. A secondary reflex suppression phase is present in genioglossus but not tensor palatini in response to negative upper airway pressure. J Appl Physiol 2010; 108:1619-24. PMID: 20378702. PMCID: PMC2886693.
  • Kezirian E, White DP, Malhotra A, Ma W, McCulloch CE, Goldberg A. Interrater reliability of drug-induced sleep endoscopy. Arch Otolaryngol Head Neck Surg 2010;136(4):393-7. PMID: 20403857.
  • Nemati S, Malhotra A, Clifford GD. Data fusion for improved respiratory rate estimation. EURASIP J Adv Signal Process 2010; 2010:926305.PMID: 20806056.  PMCID: PMC2929127.
  • Peer A, Lorber A, Suraiya S, Malhotra A, Pillar G. The occurrence of Cheyne-Stokes respiration in congestive heart failure: the effect of age. Front Psychiatry 2010; 1:133. PMID: 21423443. PMCID: PMC3059641
  • Nicholas CL, Bei B, Worsnop C, Malhotra A, Jordan AS, Saboisky JP, Chan JK, Duckworth E, White DP, Trinder J. Motor unit recruitment in human genioglossus muscle in response to hypercapnia. Sleep 2010; 33(11): 1529-1538. PMID 21102995. PMCID: PMC2954703
  • Jordan AS, White DP, Owens R, Eckert D, Rahangdale S, Yim-Yeh S, Malhotra A. The effect of increased genioglossus activity and end-expiratory lung volume on pharyngeal collapse. J Appl Physiol 2010; 109(2): 469-475. PMID: 20507968. PMCID: PMC2928593.
  • Saboisky JP, Jordan AS, Eckert DJ, White DP, Trinder JA, Nicholas CL, Gautam S, Malhotra A. Recruitment and rate-coding strategies of the human genioglossus muscle. J Appl Physiol. 2010; 109(6): 1939-1949. PMID: 20947713.
  • Scheer F, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hilton MF, Shea SA. Impact of the human circadian system, exercise and their interaction on cardiovascular function. P Natl Acad Sci 2010; 107(47): 20541-20546. PMID: 21059915. PMCID: PMC2996667.
  • Doupis J, Rahangdale  S, Gnardellis C, Pena SE, Malhotra A, Veves A.  Effects of diabetes and obesity on vascular reactivity, inflammatory cytokines and growth factors.  Obesity 2011; 19(4):729-35. PMID: 20829804.
  • Liu C, Cao Y, Malhotra A, Ling L. Sleep fragmentation attenuates the hypercapnic (but not hypoxic) ventilatory responses via adenosine A1 receptors in awake rats. Respir Physiol Neurobiol 2011; 175(1): 29-36. PMID: 20833276. PMCID: PMC3005083.
  • Nemati S, Abdala O, Bazan V, Yim Yeh S, Malhotra A, Clifford G. A non-parametric surrogate-based test of significance for T-Wave alternans detection. IEEE Trans Biomed Eng 2011; 58:1356-64. PMID: 20409986. PMCID: PMC3062089.
  • Torelli F, Moscufo N, Garreffa G, Placidi F, Romigi A, Zannino S, Bozzali M, Fasano F, Giulietti G, Djonlagic I, Malhotra A, Marciani MG, Guttmann CR. Cognitive profile and brain morphological changes in obstructive sleep apnea. Neuroimage 2011; 54(2):787-93 PMID: 20888921.
  • Sundar S, Novack V, Jarvis K, Bender SP, Lerner A, Panzica P, Mahmood F, Malhotra A, Talmor DJ. Influence of low tidal volume ventilation on time to extubation in cardiac surgical patients. Anesthesiology 2011; 114(5): 1102-1110. PMID: 21430518.
  • Sharma B, Feinsilver S, Owens R, Malhotra A, McSharry D, Karbowitz S. Obstructive airway disease and obstructive sleep apnea: effect of pulmonary function. Lung 2011; 189(1):37-41. PMID: 21132554.
  • Yim-Yeh, S, Rahangdale, S, Nguyen, A, Stevenson, K, Novack, V, Veves, A, Malhotra, A. Vascular dysfunction in obstructive sleep apnea and type 2 diabetes mellitus. Obesity 2011; 19(1): 17-22. PMID: 20523303.
  • Rahangdale S, Yim Yeh S, Novack V, Stevenson K, Barnard M, Furman M, Frelinger AL, Michaelson AD, Malhotra A. The influence of intermittent hypoxemia on platelet activation in obese obstructive sleep apnea patients. J Clin Sleep Med 2011; 7(2):172-8. PMID: 21509332. PMCID: PMC3077345 (with invited editorial)
  • Mostafiz W, Dalci O, Sutherland K, Malhotra A, Srinivasan V, Darendeliler M, Cistulli P. Influence of oral dimensions on mandibular advancement splint treatment outcome in obstructive sleep apnea. Chest 2011; 139(6): 1331-1339. PMID: 21292761.
  • Hedner J, White DP, Malhotra A, Herscovici S, Pittman SD, Zou D, Grote L, and Pillar, G. Sleep staging based on autonomic signals – a multi-center validation study. J Clin Sleep Med 2011; 7(3): 301-306. PMID:  21677901. PMCID: PMC3113970.
  • Nemati S, Malhotra A, Clifford GD. T-wave alternans patterns during sleep in healthy, cardiac disease and sleep apnea patients. J Electrocardiol 2011; 44(2):126-30. PMID: 21163493. PMCID: PMC3062089
  • Campana L, Clifford G, Trinder J, Pittman S, Malhotra A. A possible method to predict response to non-pharmacological insomnia therapy. J Clin Sleep Med 2011; 7(4): 370-375. PMID: 21897773. PMCID: PMC3161769
  • Ferreira J, Bensenor F, Rocha MJ Salge, J, Harris RS, Malhotra A, Kairalla RA, Kacmarek RM, Carvalho C. A sigmoid fit for Pressure-Volume curves of Idiopathic Pulmonary Fibrosis patients in mechanical ventilation: clinical implications. Clinics (Sao Paulo) 2011; 66(7): 1157-1163. PMID 21876967. PMCID: PMC3148457.
  • Wellman A, Eckert DJ, Jordan AS, Edwards BA, Passaglia CL, Jackson AC, Gautam S, Owens RL, Malhotra A, White DP. A method for measuring and modeling the physiological traits causing obstructive sleep apnea. J Appl Physiol 2011; 110(6): 1627-1637. PMID: 21436459. PMCID: PMC3119134.
  • Nemati S, Edwards BA, Sands SA, Berger PJ, Wellman A, Verghese GC, Malhotra A, Butler JP. Model-based characterization of ventilatory stability using spontaneous breathing. J Appl Physiol 2011; 111(1): 55-67. PMID: 21474696. PMCID: PMC3137535
  • Mandelbaum T, Scott SJ, Lee J, Mark RG, Waikar SS, Malhotra A, Howell MD, Talmor DJ,  Outcome of critically ill patients with acute kidney injury using the AKIN criteria. Crit Care Med 2011; 39(12): 2659-64. PMID: 21765352. PMCID: PMC3213281.
  • Bertisch SM, Schomer A, Kelly EE, Baloa LA, Hueser LE, Pittman SD, Malhotra A. Device-guided paced respiration as an adjunctive therapy for hypertension in obstructive sleep apnea: A pilot feasibility study". Appl Psychophys Biof 2011; 36(3): 173-179. PMID: 21523471.
  • Varvarigou V, Dahabreh IJ, Malhotra A, Kales SN. A review of genetic association studies of obstructive sleep apnea: field synopsis and meta-analysis. Sleep 2011; 34(11): 1461-1468. (invited editorial) PMID: 22043116.
  • United States Critical Illness and Injury Trials Group-Lung Injury Prevention Study Investigators. Early identification of patients at risk of acute lung injury: Evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med 2011; 183(4): 462-471. PMID: 20802164. PMCID: PMC3056224.
  • Eckert DJ, Owens RL, Kehlmann GB, Wellman A, Rahangdale S, Yim-Yeh S, White DP, Malhotra A. Eszopiclone increases the respiratory arousal threshold and lowers the apnea/hypopnea index in obstructive sleep apnea patients with low arousal threshold. Clin Sci (Lond) 2011; 120(12): 505-514. PMID: 21269278.
  • Batool S, Malhotra A, Forman J, Winkelman J, Li Y, Gao X. Restless legs syndrome and hypertension in middle aged women. Hypertension, 2011; 58(5):791-6. PMID: 21986505. PMCID: PMC3221559 (invited editorial).
  • Eckert DJ, Lo Y, Saboisky J, Jordan AS, White DP, Malhotra A. Sensori-motor function of the upper airway muscles and respiratory sensory processing in untreated obstructive sleep apnea, J Appl Physiol 2011; 111(6): 1644-53. PMID: 21885797. PMCID: PMC3233889.
  • Jordan AS, Eckert DJ, Wellman A, Malhotra A, White DP. Termination of respiratory events with and without cortical arousal in obstructive sleep apnea. Am J Respir Crit Care Med 2011; 184(10):1183-91. PMID: 21836132. PMCID: PMC3262022 (invited editorial).
  • Eastwood PR, Barnes M, Walsh JH, Maddison KJ, Hee G, Schwartz AR, Smith PL, Malhotra A, McEvoy RD, Wheatley JR, O'Donoghue FJ, Rochford PD, Churchward T, Campbell MC, Palme CE, Robinson S, Goding GS, Eckert DJ, Jordan AS, Catcheside PG, Tyler L, Antic NA, Worsnop CJ, Kezirian EJ, Hillman DR. Treating obstructive sleep apnea with hypoglossal nerve stimulation (Rapid Publication). Sleep 2011; 34(11): 1479-1486. PMID: 22043118, PMCID: PMC3198202 (invited editorial).
  • Genta PR, Eckert DJ, Gregorio MG, Danzi NJ, Moriya HT, Malhotra A, Lorenzi-Filho G. Critical closing pressure during midazolam induced sleep. J Appl Physiol 2011; 111(5):1315-22. PMID 21852408.
  • Novack V, MacFayden J, Malhotra A, Almog Y, Glynn R, Ridker P. Statin therapy and incident pneumonia: An exploratory analysis from the randomized, placebo controlled JUPITER trial. Can Med Assoc J 2012; 184:E367-72. PMID: 22431901. PMCID: PMC3328541.
  • Lee J, Nemati S, Silva I, Edwards BA, Butler JP, Malhotra A. Transfer entropy estimation and directional coupling change detection in biomedical time series. Biomed Eng Online 2012; 11:19. PMID: 22500692. PMCID: PMC3403001
  • Nicholas CL, Jordan AS, Heckel L, Worsnop C, Bei B, Saboisky JP, Eckert DJ, White DP, Malhotra A, Trinder J. Discharge patterns of human tensor palatini motor nits during sleep onset. Sleep 2012; 35(5): 699-707. PMID: 22547896. PMCID: PMC3321429.
  • Patel SR, Malhotra A, Hu F, Neuman M, Fawzi W. A prospective study of sleep duration and pneumonia risk in women. Sleep 2012; 35(1):97-101. PMID: 22215923. PMCID: PMC3242694 (invited editorial).
  • Campana LM, Owens RL, Suki B, Malhotra A. Measuring upper and lower airway resistance during sleep with the forced oscillation technique. Ann Biomed Eng 2012; 40(4):925-33 PMID: 22127514.
  • Balachandran J, Bakker J, Rahangdale S, Yim-Yeh S, Meitus J, Goldberger A,, Malhotra A. Effect of mild, asymptomatic obstructive sleep apnea on daytime heart rate variability and impedance cardiography measurements. Am J Cardiol 2012; 109(1):140-5. PMID: 21945139.
  • Engelberts D, Malhotra A, Butler J, Topulos G, Loring SH, Kavanagh B. Relative effects of negative vs. positive pressure ventilation depend on applied conditions. Intens Care Med 2012; 38(5): 879-85 PMID: 22349427.
  • Powell ED, Gay PC, Ojile JM, Litinski M, Malhotra A. A pilot study assessing adherence to auto-bilevel following a poor initial encounter with CPAP. J Clin Sleep Med 2012; 8(1): 43-47. PMID: 22334808, PMCID: PMC3266339 (invited editorial).
  • Cao Y, Li C, McGuire M, Malhotra A, Ling L. Phasic respiratory modulation of pharyngeal collapsibility via neuromuscular mechanisms in rats. J Appl Physiol 2012; 112(5): 695-703. PMID: 22052868. PMCID: PMC3198201.
  • Zhang C, Varvarigou V, Parks PD, Gautam S, Bueno AV, Malhotra A, Kales SN. Psychomotor vigilance testing of professional driver in the occupational health clinic: A potential objective screen for daytime sleepiness. J Occup Environ Med 2012; 54(3):296-302. PMID: 21826029.
  • Edwards BA, Sands SA, Eckert DJ, White DP, Butler JP, Owens RL, Malhotra A, Wellman A. Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnea. J Physiol (Lond) 2012; 590(5): 1199-211. PMID: 22219335 (invited editorial).
  • Awad K, Malhotra A, Barnett J, Quan S, Peppard P. Exercise is associated with a reduced incidence of sleep-disordered breathing. Am J Med 2012; 125(5):485-90 PMID: 224828. PMCID: PMC3339801
  • Schwartz AR, Barnes M,  Hillman D, Malhotra A, Kezirian E, Smith PL, Hoegh T, Parrish D, Eastwood P. Acute upper airway responses to hypoglossal nerve stimulation during sleep in obstructive sleep apnea. Am J Respir Crit Care Med 2012; 185(4): 420-6. PMID: 22135343. PMCID: PMC3297092
  • Djonlagic I, Saboisky J, Carusona A, Stickgold R, Malhotra A. Increased sleep fragmentation leads to impaired off-line consolidation of motor memories in humans. PLoS One 2012; 7(3):e34106. PMID: 22470524. PMCID: PMC3314699.
  • Saboisky JP, Staschuk DW, Hamilton-Wright A, Carusona A, Campana L, Trinder J, Eckert DJ, Jordan AS, McSharry D, White DP, Nandedkar S, David WS, Malhotra A. Neurogenic changes in the upper airway of obstructive sleep apnea patients. Am J Respir Crit Care Med 2012; 185(3):322-329. PMCID: PMC3006403 (invited editorial).
  • Altinas N, Arslan E, Helvaci A. Malhotra A, Relationship between obstructive sleep apnoea severity index and left ventricular function and volume. Ann Saudi Med J 2012; 32(4): 384-390. PMID: 22705609.
  • Owens RL, Edwards BE, Sands SA, Butler JP, Eckert DJ, White DP, Malhotra A, Wellman A. Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume. J Appl Physiol 2012, 113(5):691-9. PMID: 22628372 PMCID: PMC3472473 (invited editorial).
  • Owens RL, Campana LM, Hess L, Eckert DJ, Loring SH, Malhotra A. Sitting and supine esophageal pressures in overweight and obese subjects. Obesity 2012 May 4 [epub ahead of print] PMID: 22695479 PMCID: PMC3443522
  • Awad K, Drescher AA, Malhotra A, Quan SF. Effects of exercise and nutritional intake on sleep architecture in adolescents. Sleep and Breathing 2012 Jan. 31 [epub ahead of print] PMID: 22331514.
  • Scheer F, Morris C, Garcia Pierce J, Smales C, Kelly E, Malhotra A, Marks J, Shea, SA. Repeated melatonin supplementation improves sleep in hypertensive patients treated with β-Blockers; a randomized controlled trial. Sleep. 2012; 35(10):1395-402. PMID: 23024438 PMCID: PMC3443766 (invited editorial)
  • Lehman L, Saeed M, Talmor DJ, Mark R, Malhotra A. Methods of blood pressure measurement in the intensive care unit. Critical Care Medicine, in press.
  • Edwards B, Wellman A, Sands S, Trinder JA, Campana L, Connolly J, White DP, Malhotra A. Acetazolamide attenuates the ventilatory response to arousal in patients with obstructive sleep apnea. Sleep, in press.
  • Castriotta R, Hayes S, Murray S, Landrigan C, Malhotra A.  (Mis)Perceptions and interactions of sleep specialists and generalists: Obstacles to referrals to sleep specialists and the multidisciplinary team management of sleep disorders. Journal of Clinical Sleep Medicine, in press.
  • Sharma B, Bakker JP, McSharry D, Desai A, Javaheri S, Malhotra A. Adaptive servo-ventilation for treatment of sleep-disordered breathing in heart failure: A systematic review and meta-analysis. Chest 2012, 142(5):1211-1221. PMID: 22722232
  • Li Y, Mirzael F, O’Reilly E, Winkelman J, Malhotra A, Okereke O, Ascherio A, Gao X. Prospective study of restless legs syndrome and risk of depression in women. Am J Epi, in press. PMID:22805376
  • Baughman R, Malhotra A, Surdulescu V, Lower E. Armodafinil for sarcoidosis associated fatigue: Double blind, placebo controlled, cross over trial. J Pain Symptom Manage, in press. PMID: 22917711
  • Pulliam SJ, Weinstein DF, Malhotra A, Macklin EA, Berkowitz LR. Matriculating interns and sleep dysfunction:  Are some more susceptible than others? J Graduate Medical Education, in press.
  • Kahlon, S, Eurich, D, Padwal, R, Malhotra, A, Minhas-Sandhu, J, Marrie, T, Majumdar, SR, Obesity and outcomes in patients hospitalized with pneumonia, Clinical Microbiology and Infection, in press. PMID: 22963453
  • Chang, SY, Dabbagh, O, Gajic, O, Patrawalla, A, Elie, M, Talmor, D, Malhotra, A, Adesanya, A, Anderson, HL, Blum, JM, Park, PK, Gong, M, Contemporary ventilator management in patients with and at risk of ALI/ARDS, Respiratory Care in press. PMID: 22906363
  • Berger MB, Varbarigou V, Rielly A, Czeisler CA, Malhotra A, Kales SN. Employer-mandated sleep apnea screening and diagnosis in commercial Drivers. J Occup Environ Med, 2012, 54(8):1017-25. PMID: 22850349 PMCID: PMC3415601
  • Montesi S, Edwards BA, Malhotra A, Bakker, JP. The effect of continuous positive airway pressure treatment on blood pressure: A systematic review and meta-analysis of randomized controlled trials. J Clin Sleep Med 2012 ;8(5):587-96 PMID: 23066375. PMCID: PMC3459209
  • Shaikh, Z, Jaye, J, Ward, N, Malhotra, A, de Villa, M, Polkey, M, Mullen, M, Morrell, M, Patent foramen ovale in severe obstructive sleep apnea: clinical features and effects of closure, Chest, in press. PMID: 22924163
  • Sharma, B, Neilan, TG, Kwong, RY, Mandry, D, Owens, RL, McSharry, D, Bakker, JP, Malhotra, A, Evaluation of right ventricular remodeling using cardiac magnetic resonance imaging in co-existent chronic obstructive pulmonary disease and obstructive sleep apnea, Journal of COPD, in press.
  • Malhotra, A, Younes, M, Kuna, ST, Benca, R, Kushida, CA, Walsh, J, Hanlon, A, Staley, B, Pack, AI, Pien, G, Performance of an automated polysomnography scoring system versus computer-assisted manual scoring, Sleep in press.
  • Kuna ST, Benca R, Kushida CA, Walsh J, Younes M, Staley B, Hanlon A, Pack AI, Pien GW, Malhotra A. Agreement in computer-assisted manual scoring of polysomnograms across sleep centers. Sleep in press.
  • McSharry, DG, Saboisky, JP, DeYoung, P, Matteis, P, Jordan, AS, Trinder, J, Smales, E, Hess, L, Guo, M, Malhotra, A, A mechanism for upper airway stability during slow wave sleep, Sleep in press.
  • Campana, LM, Malhotra, A, Suki, B, Hess, L, Israel, E, Smales, E, DeYoung, P, Owens, RL,  The effect of lung stretch during sleep on airway mechanics in overweight and obese asthma, Respir. Physiol. Neurobiol. in press. PMID: 23041446
  • Weiss, JP, Jumadilova, Z, Johnson, TM, Fitzgerald, MP, Carlsson, M, Matire, DL, Malhotra, A, Efficacy and safety of flexible-dose fesoterodine in men and women with overactive bladder symptoms, including nocturnal urinary urgency, J. Urol. 2012 pii: S0022-5347(12)05557-7. doi: 10.1016/j.juro.2012.11.067. [Epub ahead of print]  PMID: 23159276
Other peer-reviewed publications
1.         Wellman DA, Malhotra A. White DP. Atrial pacing in sleep apnea syndrome. N Engl J Med 2002; 347(6):445-6. PMID: 12167690.
2.         Malhotra A, Ayas N, Kacmarek R.  Prone positioning of patients in acute respiratory failure.  N Engl J Med 2002; 346(4):295-7.  PMID: 11811184.
3.         Patel SR, Harris RS, Malhotra A.  Pulmonary dead space and survival. N Engl J Med 2002; 347:850-2.

Non-peer reviewed scientific or medical publications/materials in print or other media
  Reviews, chapters, monographs and editorials
  • Malhotra A, Kradin R. The pulmonary immune response to asbestos.  In: Peters GA, Peters BJ, editors.  Asbestos and Cancer. Salem, NH: Butterworth Legal; 1997. p. 1-23.
  • Schwartz D, Malhotra A, Fink M.  Cytopathic hypoxia in sepsis: an overview.  Sepsis 1999; 1:279-89.
  • Ayas N, Malhotra A, Epstein L.  Alternative therapies for sleep apnea.  Drugs Today (Barc) 1999; 35(11): 811-21. PMID: 12973373.
  • Malhotra A, Ayas N, Epstein L.  The art and science of continuous positive airway pressure therapy in obstructive sleep apnea.  Curr Opin Pulm Med 2000; 6(6): 490-495. PMID: 11100958.
  • Pillar G, Malhotra A, Lavie P.  Post-traumatic stress disorder and sleep – what a nightmare! Sleep Med Rev 2000; 4(2): 183-200. PMID: 12531165.
  • Schwartz D, Malhotra A, Fink M.  Cytopathic hypoxia in septic shock.  In: Malhotra, SK and Tuszynski J, editors.  Advances in Structural Biology. Stamford, CT:  Jai Press; 2000.  p. 65-82.
  • Schwartz DR, Malhotra A, Fink MP.  Microcirculatory weak units – an alternative explanation.  Critical Care Medicine 2000; 28:3127-8.
  • Sabatine M, Malhotra A, Systrom DM.  Pulmonary Disease. In: Sabatine, MD, editor. Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine.  Philadelphia: Lippincott Williams and Wilkins; 2000. p. 2-1-21.
  • McCowen K, Malhotra A, Bistrian B.  Stress-induced hyperglycemia. Critical Care Clinics. 2001; 17(1):107-24. PMID: 11219223.
  • Malhotra A, Schwartz DR, Ayas N, Stanchina M, White DP.  The treatment of oxygen-induced hypercarbia.  Lancet 2001; 357(9259):884-5. PMID: 11265981.
  • Malhotra A, Schwartz D.  Lung Cancer.  In: Hess D, MacIntyre N, Mishoe S, Galvin WF, Adams AB, Saposnick AB, editors. Respiratory Care: Principles and Practice. Philadelphia: WB Saunders; 2002.  p. 1151-67
  • Malhotra A, White DP.  The pathogenesis of obstructive sleep apnea.  In McNicholas W, Phillipson E, editors.  Breathing Disorders in Sleep. London: WB Saunders; 2002. p. 44-64.
  • Malhotra A, White DP.  Obstructive sleep apnoea.  Lancet 2002; 360(9328): 237-45. PMID: 12133673.
  •  McCowen KC, Malhotra A.  The correlation between obstructive sleep apnea and low gonadotropin secretion in men.  Sleep Med 2003; 4:83-4.
  •  Malhotra A, Fogel R, White DP.  Disorders of excessive sleepiness. In: Neurological Therapeutics: Principles and Practice. Noseworthy JH, editor. London: Martin Dunitz Publishers; 2003. p. 1306-1310.
  • Carden K and Malhotra A. The debate about gender differences in obstructive sleep apnea.  Sleep Med 2003; 4(6):485-7. PMID: 14607341.
  • Bajwa E, Malhotra A, Thompson T.  Methods of monitoring shock. Seminars in Respiratory and Critical Care Medicine2004; 25(6):629-644. PMID: 16088506.
  • Stanchina M, Malhotra A, White DP.  An evidenced-based review of the diagnosis and treatment of respiratory disorders of sleep. In Crapo JD, Glassroth JL, Karlinsky JB, Talmadge EK, editors. Baum’s Textbook of Pulmonary Disease, 7th Ed. Philadelphia: Lippincott; 2004. p. 1425-1450.
  • Bajwa E, Mouded M, Systrom DM, Malhotra A.  Pulmonary Disease. In: Sabatine MS, editor. Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. 2nd Ed. Philadelphia: Lippincott Williams and Wilkins; 2004. p. 2:1-2:22.
  • Oddo M, Liaudet L, Patel SR, Wain J, Malhotra A. Open-lung biopsy for ARDS Patients.  Chest 2004; 126:1003-4.
  • Fogel RB, Malhotra A, White, DP.  Pathophysiology of obstructive sleep apnoea/hypopnoea syndrome.  Thorax 2004; 59(2): 159-163. PMID: 14760159. PMCID: 1746928.
  • Inoue K, Takano H, Yanagisawa R, Sakurai M, Yoshikawa T, Patel S, Wain J, Malhotra A.  Surgical stress in ARDS open-lung biopsy.  Chest 2004;126:1383-4
  • Malhotra A, Berry R, White DP.  Central sleep apnea. In: Carney PR, Berry RB, Geyer J, editors. Clinical Sleep Disorders.  Philadelphia: Lippincott; 2005. p. 331-46.
  • Ting L, Malhotra A.  Disorders of Sleep: an overview.  Prim Care 2005; 32(2):305-18. PMID: 15935187.
  • Malhotra A, Jordan AS.  Surface tension and sleep apnea: a sticky business.  Sleep 2005; 28(4):392-3. PMID: 16172618.
  • Kacmarek R and Malhotra A.  High frequency oscillatory ventilation: what large animal studies have taught us!  Critical Care Medicine 2005; 33(3S):S148-54. PMID: 15753721 PMCID: 2278170.
  • Jordan A, Malhotra A.  Pharyngeal lumen: both length and size matter.  J Clin Sleep Med 2005; 1(3): 264-265. PMID: 17566186.
  • Pillar G, Harder L, Malhotra A.  Trauma and post-traumatic stress disorder. In: Chang T, Vihtelic CM, Gold C, Lydic R, and Baghdoyan HA, editors.  Encyclopedia of Sleep Medicine.  New York: John Wiley & Sons; 2006: 857-66.
  • Malhotra A, Jordan AS.  Did fat boy Joe need hormone replacement?  Sleep 2006; 29(1):16-8. PMID: 16453975.
  • Malhotra A.  Intensive insulin in intensive care.  New Engl J Med, Invited editorial 2006; 354(5):516-8. PMID: 16452564. PMCID: 2287193.
  • Kacmarek RM, Villar J, Malhotra A.  Modes of mechanical ventilation.  In: Albert RK, Slutsky A, Ranieri M, Takala J, Torres A, editors.  Clinical Critical Care Medicine. Philadelphia: Elsevier Publishing Company; 2006. p. 109-120. 
  • Kacmarek RM, Malhotra A.  Equipment required for home mechanical ventilation.  In: Tobin MJ, editors.  Principles and Practice of Mechanical Ventilation. 2nd Ed.  New York: McGraw Hill; 2006. p. 97-128
  • Heinzer R., Jordan AS, Malhotra A.  Sleep Apnea Syndrome.  In: Khoo, M., editor.  Wiley Encyclopedia of Biomedical Engineering.  New York: John Wiley and Sons; 2006. p. 18-34.
  • Yim S, Jordan AS, Malhotra A.  Obstructive sleep apnea, clinical presentation, diagnosis and treatment.  In: Randerath WJ, Sanner BM, Somers VK, editors.  Sleep Apnea – Current diagnosis and treatment.  Basel: Karger;  2006. 35:118-136.
  • Hammer L, Dessertaine G, Timset JF, Aberegg SK, Tamler R, Leroith D, Roth J, Van den Berghe G, Wilmer A, Boullon R, Malhotra A.  Intensive insulin in the medical intensive care unit, New Engl J Med. 2006;354: p. 2069-71.
  • Malhotra A and Patel SR. Lung biopsy in ARDS: Is it worth the risk?  Critical Care 2006; 10(4): 160. PMID: 16941755. PMCID: 1750997.
  • Yim S, Malhotra A, Veves A. Anti-oxidants and CVD in diabetes: Where do we stand now? Current Diabetes Reports 2007; 7:8-13. PMID: 17254512.
  • Eckert D, Jordan A, Merchia P, Malhotra A. Central sleep apnea: Pathophysiology and treatment, Chest 2007; 131(2):595-607. PMID: 17296668. PMCID: PMC2287191.
  • Loring SH and Malhotra A. Inspiratory efforts during mechanical ventilation: is there risk of barotrauma? Chest 2007; 131(3):646-648. PMID: 17356075. PMCID: PMC2278167.
  • Shochat T, Pillar G, Malhotra A. Aging and sleep, invited review. Int J Sleep Disorders 2007;1(3):92-101.
  • Benson A, Bajwa E, Malhotra A.  Pulmonary Disease. In: Sabatine MS, editor. Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Third edition. Philadelphia: Lippincott Williams and Wilkins; 2007. p. 2:1-2:23.
  • Yim S, Fredberg JJ, Malhotra A. CPAP for asthma: not a big stretch?  European Respiratory Journal 2007; 29(2):226-228. PMID: 17264319
  • Eikermann M, Magder S, Malhotra A. Is brachial artery peak velocity variation ready for prime time? Chest 2007; 131:1279-1281. PMID: 17494778. PMCID: PMC2278172.
  • Eikermann M, Chamberlin N, Gerber H, Malhotra A. Muscle weakness after administration of neuromuscular blocking agents: Don’t immobilize the diaphragm unnecessarily.  Crit Care Med 2007; 35(6):1634-1635. PMID 17522551.
  • Malhotra A. Low Tidal Volume Ventilation in the acute respiratory distress syndrome. N Engl J Med 2007; 357:1113-1120. PMID: 17855672. PMCID: PMC2287190.
  • Eckert D, Saboisky J, Jordan A, Malhotra A. Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea. J Clin Sleep Med 2007; 3(6):570-3. PMID 17993036. PMCID: PMC2045709.
  • Chiche L, Forel JM, Papazian L, Asakura Y, Komatsu T, Busch T, Bercker S, Kaisers U, Malhotra A.  Low tidal volume ventilation. N Engl J Med 2007; 357: 2518-2520.
  • Malhotra A, Kacmarek RM.  Mechanical ventilation.  In: Hagberg C, editor. Benumof’s airway management: principles and practice. Philadelphia: Lippincott Publishing Co; 2007. p. 1079-1122.
  • Eikermann M and Malhotra A. Predictive value of stimulated muscle force assessment incritically ill patients, Editorial.Acta Anaesthesiol Scand. 2008; 52(1):1-2. PMID 18173429.
  • Goodwin AJ, Bajwa EK, Malhotra A.  Minimally invasive cardiology.  In: Irwin RS, Cerra FB, Rippe JM, editors.  Irwin and Rippe’s Intensive Care Medicine, 6th Edition. Philadelphia: Lippincott Williams & Wilkin; 2008. p. 261-274.
  • Eckert D and Malhotra A.  Pathophysiology of adult obstructive sleep apnea.  Proceedings of the American Thoracic Society2008; 5(2):144-53. PMID: 18250206. PMCID: PMC2628457.
  • Malhotra A and Hillman D.  Obesity and the lung: Obesity, respiration and intensive care. Thorax 2008; 63(10):925-931.  PMID: 18820119. PMCID: PMC2711075.
  • Malhotra A, Bertisch S, and Wellman DA.  Complex apnea isn’t a real disease. J Clin Sleep Med invited Pro/Con 2008; 4(5): 406-408. PMID: 18853695. PMCID: PMC2576324.
  • Owens R, Eckert D, Yeh S, Malhotra A. Upper airway function in the pathogenesis of obstructive sleep apnea: A review of the current literature.  Curr Opin Pulm Med invited review. 2008; 14(6):519-24. PMID: 18812828. PMCID: PMC 2697390.
  • Yim Yeh S, Rahangdale S, Malhotra A. Metabolic syndrome, OSA and CPAP: A weighty issue. Chest 2008;134(4):675-676. editorial. PMID: 18842905.
  • Owens R, Yim Yeh S, Malhotra A. CO Poisoning or CO Protection. Chest 2008; 134(5):895-6. editorial.  PMID: 18988771
  • Rahangdale S, Campana L, Malhotra A.  Not so good vibrations, Sleep 2008;31(9):1204-05. PMID: 18788644, PMCID: PMC2542974.
  • Rahangdale S, Yim Yeh S, Malhotra A,  Veves A. Therapeutic interventions and oxidative stress in diabetes. Frontiers in Bioscience 2009; 14:192-209. PMID: 19273063.
  • Malhotra A and Loscalzo J. Cardiovascular complications of sleep disorders: An overview. Progress in Cardiovascular Diseases (Guest Editor A Malhotra) 2009; 51(4):279-84. PMID: 19110129. PMCID: PMC2722952.
  • Eckert DJ, Malhotra A, Jordan AS.  Mechanisms of apnea.  Progress in Cardiovascular Diseases (A. Malhotra guest editor) 2009; 51(4):313-23. PMID: 19110133.
  • Saboisky J, Chamberlin N, Malhotra A. Promising therapeutic targets in sleep apnea, invited review. Expert Opinion on Therapeutic Targets 2009; 13(7):795-809. PMID: 19530985. PMCID: PMC2729816.
  • Atkeson A, Yim Yeh S, Malhotra A, Jelic S.  Endothelial function in obstructive sleep apnea.  Progress in Cardiovascular Diseases (Guest Editor A. Malhotra) 2009; 51(5):351-362.  PMID: 19249441.
  • Talmor D, Malhotra A, Loring SH. Esophageal pressure in acute lung injury.  N Engl J Med 2009; 360:831-833.
  • Loring SH, Garcia-Jacques M, Malhotra A.  Pulmonary characteristics in COPD and mechanisms of increased work of breathing.  J Appl Physiol 2009, 107(1): 309-314. PMID: 19359620. PMCID: PMC2711781.
  • Campana L, Eckert D, Patel SR, Malhotra A. OSA Pathophysiology. Indian Journal of Medical Research 2010, 131: 176-187. PMID: 20308743 (invited review).
  • Rahangdale S and Malhotra A. The arousal threshold in OSA. Frontiers in Neuroscience. E-book (vol. 3, issue 3), Theme: Sleep and Dreams. http://www.frontiersin.org/books/e_book__frontiers_in_neuroscie/33/all_books
  • Owens R, Wellman A, Malhotra A. The chicken or egg debate in OSA pathogenesis: Comment on Loewen et al. "Determinants of ventilatory instability in Obstructive Sleep Apnea (OSA): Inherent or acquired?" Sleep 2009; 32(10): 1255-1256. PMID 19848354. PMCID: PMC2753803.
  • Saboisky J, Eckert D, Malhotra A. Stable breathing through deeper sleeping. Thorax 2010; 65(2):95-6. PMID: 20147587 (invited editorial).
  • Owens R, Harris RS, Malhotra A. Is the way to man’s heart (and lung) through the abdomen? Critical Care 2009; 13(6): 199. PMID: 19909491. PMCID: PMC2811916 (invited editorial).
  • Goodwin A, Bajwa E, Malhotra A. Non-invasive cardiology. In: Irwin RS, Rippe JM, editors. Irwin and Rippe’s Intensive Care Medicine. 7th Edition. Philadelphia: Lippincott; 2012.  p. 245-257.
  • Goodwin A, Bajwa E, Malhotra A. In: Irwin RS, Rippe JM, Lisbon A, Heard SO, editors. Irwin and Rippe’s Procedures, Techniques and Minimally Invasive Monitoring in Intensive Care Medicine. 5th edition. Philadelphia: Lippincott; 2012. p. 276-288.
  • Sharma B, Owens R, Malhotra A. Sleep in congestive heart failure. Medical Clinics of North America 2010; 94(3): 447- 464.  PMID 20451026.
  • Gladysheva K, Malhotra A, Owens R. Influencing the decline of lung function in COPD: Use of pharmacotherapy. International Journal of COPD 2010; 5: 153-164. PMID: 20631815. PMCID: PMC2898088.
  • Thomas Z, Bandali F, McCowen K, Malhotra A. Drug-induced endocrine disorders in the intensive care unit. Crit Care Med 2010; 38(6S): S219-230. PMID: 20502175.
  • Edwards B, Driscoll D, Ali A, Jordan AS, Trinder J, Malhotra A. “Aging and sleep: physiology and pathophysiology”, Seminars in Respiratory and Critical Care Medicine 2010; 31(5): 618-633. PMID: 20941662.
  • Eastwood PR, Malhotra A, Palmer LJ, Kezirian EJ, Horner RL, Ip MS, Thurnheer R, Antic NA, Hillman DR. Obstructive sleep apnoea: From pathogenesis to treatment: Current controversies and future directions. Respirology 2010; 15(4):587-95. PMID: 20136736.
  • Malhotra A, and Owens R. What is central sleep apnea? Respiratory Care 2010; 55(9):1168-78. PMID: 20799999. (Invited contribution from Expert Roundtable).
  • Owens R, and Malhotra A. Sleep disordered breathing and chronic obstructive pulmonary disease: The overlap syndrome. Respiratory Care 2010; 55(10): 1333-1346. PMID 20875160 (Invited contribution from Expert Roundtable).
  • McSharry D, Eckert D, Malhotra A. Central sleep apnoea. In: McNicholas WT and Bonsignore MR, editors. Sleep Apnoea. Sheffield, UK: European Respiratory Society; 2010. p.381-395. (chapter 22 in European Respiratory Monographs, volume 50; see table of contents at http://erm.ersjournals.com/content/ermsa/1.toc)
  • Djonlagic I and Malhotra A. Risk of stroke from sleep apnea in men and women. Expert Rev Neurother 2010; 10(8):1267-71. PMID: 20662752.
  • Sharma B, McSharry D, Malhotra A. Sleep disordered breathing in patients with heart failure: Pathophysiology and management. Curr Treat Options Cardiovasc Med 2011; 13(6):506-16. PMID: 21894522.
  • Shih JL and Malhotra A. Could vitamins be helpful to sleep apnea patients? Chest 2011; 139(2): 237-238. PMID: 21285049 (invited editorial).
  • Owens RL, Wellman A, Malhotra A. Which OSA patients might respond to nasal valves? J Clin Sleep Med 2011; 7(1): 23-24. PMID: 21344055 PMCID: PMC3041631.
  • Kohli P, Balachandran J, Malhotra A. Obstructive sleep apnea and the risk for cardiovascular disease. Current Atherosclerosis Reports 2011; 13(2): 138-46 PMID: 21253882.
  • Strohl KP, Butler JP, Malhotra A. Mechanical properties of the upper airway. Compr Physiol2012, 2:1-20.
  • Malhotra A, Butler J, Wellman A, The pharyngeal airway: Is bigger really better? Chest 2012; 141(6): 1372-1375. PMID: 22670014.
  • Owens RL, Edwards BA, Malhotra A, Wellman A. Expiratory resistance increases end-expiratory lung volume during sleep. Am J Respir Crit Care Med 2012; 185(8): e10-1. PMID: 22505761 PMCID: PMC3360575.
  • Malhotra A, Disorders of Control of breathing. In Golden L, Schafer AI, editors. Goldman’s Cecil Medicine. 24th Edition. Philadelphia: Elsevier; 2012. p. 527-531.
  • Kohli P, Schwab R, Malhotra A. Management of sleep disordered breathing. In: Avidan AY and Zee PC, editors. Handbook of Sleep Medicine Philadelphia: Lippincott Williams & Wilkins; 2012. p. 127-147.
  • Bakker JP, Sharma B, Malhotra A. Obstructive sleep apnea: the elephant in the cardiovascular room. Chest 2012; 141(3): 580-581. PMID:22396556
  • Malhotra A. Future of sleep apnea therapy using a mechanistic approach. Sleep Science 2012; 5:33-37.
  • Montesi S, Bajwa E, Malhotra A. Biomarkers of sleep apnea, Chest 2012, 142(1): 239-245. PMID: 22796846   PMID: 22796846 PMCID: PMC3418859
  • Malhotra A. Cardiovascular consequences of sleep disorders. Sleep Science 2012, 5(2): 68-72.
  • Rice M, Hibbert K, Malhotra A. Pulmonary Disease. In: Sabatine MS, editor. Pocket Medicine. 4th Edition. Philadelphia: Lippincott, Williams & Wilkins; in press.
  • Awad K, Raju D, Malhotra A. Sleep Medicine. In: Greer D, editor. Pocket Neurology, in press.
  • Rice M, Hibbert K, Malhotra A. Acid Base Balance. In: Urman R, Frendl G, editors.  Pocket ICU. Philadelphia: Lippincott, Williams & Wilkins; 2012. in press.
  • Malhotra A and Strollo P. Selecting the Research Question. AASM Handbook on Research, in press.
  • Velasquez A, Rahangdale S, Malhotra A. CPAP effect on cardiovascular disease. Sleep Medicine Clinics, in press.
  • Pillar G, White DP, Malhotra A. Age-related changes in the pharyngeal structure and function in sleep apnea and normal subjects.  In: Pandi-Perumal SR, Monti JM, and Monjan A, editors. Principles and Practice of Geriatric Sleep Medicine. Cambridge: Cambridge University Press, in press.
  • Nguyen A, Yim S, Malhotra A,  Theories of OSA pathogenesis.  In: Obstructive Sleep Apnea.  (two volume textbook, Taylor and Francis), in press.
  • Hibbert KA, Rice M, Malhotra A. Obesity and the acute respiratory distress syndrome. Chest 2012, 142(3):785-90. PMID: 22948584 PMCID: PMC3435141
  • Zhang, C, Berger, M, Malhotra, A, Kales, SN, Portable diagnostic devices for identifying obstructive sleep apnea among commercial motor vehicle drivers: Considerations and unanswered questions, Sleep, 2012, 35(11): 1481-1489. PMID: 23115397. (invited editorial)
  • Mayson, D, Awad, K, Neilan, T, Malhotra, A, Obstructive sleep apnea in the elderly: Extent of the problem, Current Cardiovascular Risk Reports, in press.
  • Butler, JP, Owens, RL, Malhotra, A, Wellman, A, Con: The upper airway (probably) does not behave as a Starling resistor: the “tippy tongue” alternative. J. Physiol. (London) in press.
  • Jordan, AS, McSharry, D, Malhotra, A, Seminar: Obstructive Sleep Apnoea, Lancet, invited review, accepted.
  • Sundar, E and Malhotra, A, Unanswered questions in sleep and anesthesia, Sleep Medicine Clinics, in press.
  Books/Textbooks for the medical or scientific community
1.          Lavie P, Pillar Giora, Malhotra A. Sleep disorders: Diagnosis, management, and treatment; a
handbook for clinicians. London: Martin Dunitz; 2002.
Group materials into the following categories:
-Proceedings of meetings or other non-peer reviewed research publications
-Reviews, chapters, monographs and editorials
-Books/Textbooks for the medical or scientific community
-Case reports
-Letters to the Editor
For each item indicate:
-Type of material (e.g., syllabus, teaching case)
-If published in print or on the web, provide citation
-Intended audience (including course number if applicable) and brief description of how the material is used locally (at HMS), regionally, nationally or internationally; if developed as a member of a committee, describe your contribution (1-2 sentences)

Clinical Guidelines and Reports For each item indicate:
-Type of material (e.g., clinical protocol or standard of care)
-If published in print or on the web, provide citation
-Description of the how the material is used locally (at HMS), regionally, nationally or internationally; if developed as a member of a committee, describe your contribution (1-2 sentences)

Epstein LJ, Kristo D, Strollo PJ, Friedman N, Malhotra A, Patil SP, Ramar K, Rogers R, Schwab RJ, Weaver EM, Weinstein MD.  Clinical guideline for the evaluation, management, and long-term care of OSA in Adults.  Journal of Clinical Sleep Medicine 2009;5(3):263-276 PMID: 19960649 PMCID: PMC2699173.
This guideline, which I helped to develop, is used internationally to guide sleep apnea management. AHRQ (Agency for Healthcare Research and Quality): Future research needs for the diagnosis of obstructive sleep apnea, identification of future research needs from comparative effectiveness review 32 (member of expert Stakeholder Panel)
Diagnosis Report: http://www.effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productid=952
Treatment Report: http://www.effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayProduct&productID=955

Narrative Report

I am an expert in the field of Sleep Medicine and devote the majority of my effort to research. The rest of my time is spent on clinical and administrative duties, as well as numerous teaching/training activities.

As a result of my investigative work, OSA is no longer considered a single entity but instead is understood as one with multiple physiological mechanisms.  This critical expansion in knowledge allows for the successful individualization of therapy. Some patients get sleep apnea for primarily anatomical issues, and such individuals respond to anatomical manipulations such as upper airway surgery.  Using computational modeling and enlisting surgical collaborators, we have identified individuals who are likely to respond to such manipulations. Other patients have issues primarily with  pharyngeal dilator motor control, and they respond to efforts to change hypoglossal motor output (e.g., hypoglossal nerve stimulation).  Another identifiable group has instability in ventilatory control (elevated loop gain); we have shown that they respond to interventions such as oxygen or acetazolamide.  There is probably a subset of OSA patients in whom many underlying mechanisms exist. Such patients likely respond to combination therapy addressing several therapeutic targets. Our work has paved the way to successful pharmacological therapy for OSA, a key step forward. I am currently PI or Brigham PI for several major NIH grants and also have AHA Established Investigator funding.

Based on my background in applied physiology, I have also been working in other areas of respiratory biology, most notably in mechanical ventilation as it pertains to ARDS.  My role for this work is primarily one of a mentor, whereby I help many junior people get involved in and excited about physiological research. I have received teaching awards from the residents and fellows at Harvard-affiliated institutions, as well as commendations for best presentations at many professional meetings. I have also participated in teaching by giving Grand Rounds and lecturing in CME courses from local to international settings. For the past 12 years, I have co-directed HST 100 in Advanced Respiratory Physiology (with Professor Jeffrey Drazen and Stephen Loring).

I remain active clinically as Clinical Chief of the BWH Sleep Medicine Division and have attended in the ICUs at all of the major Harvard teaching hospitals.  Most recently I attended in the ICU at King Faisal Hospital in Rwanda. My work with the ACGME clinical sleep fellowship has led to better trainee education and improved patient care, resulting in an AASM Academic Program of Distinction Award for BWH. Our clinical care model is being implemented globally.

I have multiple administrative duties. In 2015, I will be President of the American Thoracic Society, the world's largest and most prestigious respiratory organization. I have also been involved in founding and co-organizing major national sleep courses. I have participated in numerous committees for U.S. and international organizations and institutions, including many grant review roles. Locally, I have served as a long-standing member of 7 Harvard and Brigham committees, including as Co-Chair of the Training Grant Writing Committee.

I look forward to continuing my participation in research, teaching/training, and clinical and administrative activities at Harvard and its affiliated institutions.