Untitled Document

Dr Ian M Adcock

Professor of Respiratory Cell and Molecular Biology

Guy Scadding Building,
National Heart & Lung Institute
Imperial College London
Dovehouse Street
London SW3 6LY
Telephone: +44 (0)207 351 8878
Fax: +44 (0)207 351 8126
E-mail: ian.adcock@imperial.ac.uk

Educational Qualifications:
B.Sc. (2.i) in Biochemistry/Physiology, Bedford College, University of London.
Ph.D. Studentship, Dept. Pharmacology, UMDS, London.
2010: Fellow of the Society of Biologists

Research/Training Experience
1986-93 Post-doctoral Research Fellow
1993-98 Lecturer, Thoracic Medicine, NHLI, London
1998-00 Senior Lecturer, Airways Disease Section, NHLI, Imperial College
2000-04 Reader, Airways Disease Section, NHLI, Imperial College
2004-on Professor of Respiratory Cell & Molecular Biology, NHLI, Imperial College London

Measures of Esteem
Member ERS/ATS Task Force on Outcomes in COPD Clinical Trials
Member ERS/ATS Task Force on Severe Asthma
Member GMEC in Respiratory Disease
PI MRC/Asthma UK Centre in Asthma and Allergic Diseases
PI Wellcome Trust Centre for Infectious Diseases
PI Biomedical Research Unit (BRU) in COPD and Asthma at RBH
Member of the MRC Advisory Board (2003-2004).
Member of the MRC College of Experts (2002-2009).
Member of NIH Asthma Centre Review Panels 2007, 2011, 2012.
Asthma UK Research Grants Committee (2001 – 2004).
Clinical Research Committee Royal Brompton Hospital (1997 – present).
Secretary ERS Assembly 5 (Airways Diseases) 2011-2013.
Formerly Head Airway Pharmacology Section 5.1, Member ERS Council (2005-2008)
Member of ATS Programme Committee 2010-2013
Editorial Board Membership: Respiratory Research, Respiration, Pulmonary Pharmacology and Therapeutics, Journal of Inflammation, European Journal of Pharmacology, Drug Discovery Today, Journal of Pharmacology & Experimental Therapeutics and Therapeutic Advances in Respiratory Disease.
Ranked in top 25 most cited researchers within Europe in Respiratory Disease.

Current Research Funding
MRC, Regulation of IL-13 Transcription in Human T-Cells by GATA-3/NFAT complexes: modulation by corticosteroids
Royal Society, Action of the Adenosine A3 Receptor Ligand CI-IB-MECA in Dendritic Cells
EU-IMI, Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (UBIOPRED)
BBSRC, The role of PI3K and GSK3 in steroid insensitivity in COPD
Asthma UK, Global analysis of GR DNA binding in severe asthma
EPSRC,  Improved inhibition of HDAC2 by modification of curcumin
MRC, MIF function in COPD
MRC, Non-NF-kB-driven mechanisms of inflammation in severe COPD
MRC, non-smoking COPD
MRC, MRC-ABPI initiative - Innate immunity and fibrosis
Wellcome Trust, Role of acetylation and methylation in COPD
Pfizer, Understanding inflammatory mechanisms and steroid resistance in COPD

Recent Publications (out of >280)
Forte G et al., Inhibition of CD73 Improves B Cell-Mediated Anti-tumor Immunity in a Mouse Model of Melanoma. J Immunol. 2012 Jul 23. [Epub ahead of print]

Wada H et al., Up-regulation of blood arachidonate (20:4) levels in patients with chronic obstructive pulmonary disease. Biomarkers. 2012 May 30. [Epub ahead of print]

Tomita K et al., STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects. J Inflamm (Lond). 2012 Mar 9;9:5.

  • Ngkelo A et al., LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Gi-alpha dependent PI-3kinase signalling. J Inflamm (Lond). 2012 Jan 12;9(1):1.
  • Yao X et al., Coordinated regulation of IL-4 and IL-13 expression in human T cells: 3C analysis for DNA looping. Biochem Biophys Res Commun. 2012; 417(3):996-1001.
  • Barnes PJ, Adcock IM. Chronic obstructive pulmonary disease and lung cancer: a lethal association. Am J Respir Crit Care Med. 2011 Oct 15;184(8):866-7.
  • Kirkham PA et al., Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011 Oct 1;184(7):796-802.
  • Mercado N et al., p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma. Mol Pharmacol. 2011 Dec;80(6):1128-35.
  • Caramori G et al., Immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisy. PLoS One. 2011;6(7):e22637.
  • Bockmühl Y et al., Differential regulation and function of 5'-untranslated GR-exon 1 transcripts. Mol Endocrinol. 2011 Jul;25(7):1100-10.
  • Caramori G et al., Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer. Thorax. 2011 Jun;66(6):521-7.
  • Adcock IM et al., Chronic obstructive pulmonary disease and lung cancer: new molecular insights. Respiration. 2011;81(4):265-84.
  • Sorrentino R et al., B Cells contribute to the Anti-tumour Activity of CpG-ODN in a Mouse Model of Metastatic Lung Carcinoma. Am J Respir Crit Care Med. 2011 May 15;183(10):1369-79.
  • Bousquet J et al., Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med. 2011 Jul 6;3(7):43.
  • Morello S et al., NK1.1 cells and CD8 T cells mediate the antitumor activity of Cl-IB-MECA in a mouse melanoma model. Neoplasia. 2011 Apr;13(4):365-73.
  • Triantaphyllopoulos K et al., A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice. Am J Physiol Lung Cell Mol Physiol. 2011 May;300(5):L691-700.
  • Varani K et al., Oxidative/nitrosative stress selectively altered A(2B) adenosine receptors in chronic obstructive pulmonary disease. FASEB J. 2010 Apr;24(4):1192-204.
  • Price LC et al., Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in rats. Eur Respir J. 2011 Apr;37(4):813-22.
  • Auffray C et al,, An integrative systems biology approach to understanding pulmonary diseases. Chest. 2010 Jun;137(6):1410-6.
  • Sorrentino R et al., Plasmacytoid dendritic cells alter the antitumor activity of CpG-oligodeoxynucleotides in a mouse model of lung carcinoma. J Immunol. 2010; 185(8):4641-50.
  • Marwick JA et al., A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2010 May;125(5):1146-53.
  • Ford PA et al., Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD. Chest. 2010 Jun;137(6):1338-44.
  • Charron CE et al., Hypoxia-inducible factor 1alpha induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2 transcription. J Biol Chem. 2009 Dec 25;284(52):36047-54.
  • Mortaz E et al., Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor. Eur Respir J. 2010 Apr 22. [Epub ahead of print].
  • Di Stefano A et al., Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD. Thorax. 2009 Nov;64(11):968-75.
  • Di Stefano A et al., T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin Exp Immunol. 2009; 157(2):316-24.
  • Wort SJ et al., Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites. J Biol Chem. 2009 Sep 4;284(36):24297-305.
  • Ho SC et al., Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kB repressing factor. J Immunol. 2009; 183(1):411-20.
  • Williams AE et al., MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy. PLoS One. 2009; 4(6):e5889.
  • Barnes PJ, Adcock IM. Glucocorticoid resistance in inflammatory diseases. Lancet. 2009; 373(9678):1905-17.
  • Maneechotesuwan K et al., Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease. PLoS Med. 2009; 6(5):e1000076.
  • Marwick JA et al., Inhibition of PI3Kd restores glucocorticoid function in smoking-induced airway inflammation in mice. Am J Respir Crit Care Med. 2009; 179(7):542-8.
  • Adcock IM et al., New targets for drug development in asthma. Lancet. 2008; 372(9643):1073-87.
  • Bhavsar P et al., Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma. Thorax. 2008; 63(9):784-90.
Maneechotesuwan K et al., Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils. Chest. 2007; 132:98-105.

Issa R et al., Corticosteroid inhibition of growth-related oncogene protein-alpha via mitogen-activated kinase phosphatase-1 in airway smooth muscle cells. J Immunol. 2007; 178:7366-75.

Maneechotesuwan K et al., Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3. J Immunol. 2007; 178:2491-8.

Vasavda N et al., Expression of nonmuscle cofilin-1 and steroid responsiveness in severe asthma. J Allergy Clin Immunol. 2006; 118:1090-6.

Morello S et al., IL-1b and TNF-a regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kB binding to the proximal promoter. J Immunol. 2006; 177:7173-83.

Hew M et al., Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. Am J Respir Crit Care Med. 2006; 174:134-41.

Ito K et al., Update on glucocorticoid action and resistance. J Allergy Clin Immunol. 2006; 117:522-43.

Ito K et al., Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kB suppression. J Exp Med. 2006; 203:7-13.

Lee KY et al., NF-kB and activator protein 1 response elements and the role of histone modifications in IL-1b-induced TGF-b1 gene transcription. J Immunol. 2006; 176:603-15.

Varani K et al., Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006; 173:398-406.

Ricciardolo FL et al., Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2005; 116:1028-35.

Maneechotesuwan K et al., Formoterol attenuates neutrophilic airway inflammation in asthma. Chest. 2005; 128:1936-42.

Ito K et al., Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med. 2005; 352:1967-76.

Usmani OS et al., Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med. 2005; 172:704-12.