Untitled Document



Name: Philip Christy Hopewell, MD

Address: Division of Pulmonary and Critical Care Medicine Room 5K1
San Francisco General Hospital
San Francisco, CA. 94110
Phone: 415 206 8314
e-mail: phopewell@medsfgh.ucsf.edu

Education:
1961: West Virginia University, BS (pre-medicine)
1965: West Virginia University, M.D. (medicine)
1965-66: Intern, San Francisco General Hospital
1968-70*: Resident, Medicine, University of California, San Francisco
(November, 1969 – June, 1970 Leave of absence to serve as Tuberculosis Consultant, Ministry of    Health, Federal Military Government, Nigeria)
1970-71: Chief Resident, Medicine, University of California, San Francisco, San Francisco General Hospital
1971-73: Fellow in Pulmonary Disease, University of California, San Francisco

Licenses  Certification:
California license no. G17780
1972: American Board of Internal Medicine
1973: Subspecialty Board in Pulmonary Disease

Principal Positions:
1973-80: Assistant Professor in residence, University of California, San Francisco
1980-86: Associate Professor in residence, University of California, San Francisco
1986-present: Professor in residence, University of California, San Francisco
1998-2004: Associate Dean for San Francisco General Hospital, University of California, San Francisco
Current Position:   Professor of Medicine, Department of Medicine University of California, San Francisco
Administrative Title:   Director, Curry International Tuberculosis Center

Other Positions Held Concurrently:
1973-78: Director, Respiratory Care Unit, San Francisco General Hospital
1978-84: Director, Pulmonary Function Laboratory, San Francisco General Hospital
1982-93: Director, Clinical Training Program in Pulmonary Diseases, University of California, San Francisco
1986-97: Associate Chief, Medical Service, San Francisco General Hospital
1989-98: Chief, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital
1993-96: Acting Associate Director, General Clinical Research Center, San Francisco General Hospital
1993-98: Director, Robert Wood Johnson Foundation National Tuberculosis Program
1993-present: Founding Director and principal investigator, Francis J. Curry National Tuberculosis Center
2005-present: Senior advisor and core faculty, Global Health Sciences, University of California, San Francisco

Ancillary Positions

1981-82: Medical Officer, World Health Organization, Tuberculosis and Respiratory Disease Program. Based in Lima Peru (during sabbatical leave from UCSF)
2003: Medical Officer, Stop Tuberculosis Department, World Health Organization, Geneva (during sabbatical leave from UCSF)

Honors and  Awards

1988: California Tuberculosis Controllers Association: Rentlin Award for Contributions to the Control of Tuberculosis in California
1998: American Lung Association of California: California Medal
1998: American College of Chest Physicians; Louis Mark Award
2004: American Thoracic Society: E.L. Trudeau Award
2004: Medical Staff, San Francisco General Hospital: Rapaport Award
2007: American Thoracic Society: World Lung Health Award
2007: Indian Medical Association: Honorary Membership
2007: University of California, San Francisco, School of Medicine: Gold Headed Cane Society
2008: University of California, San Francisco: Lifetime Achievement in Mentoring Award
2009: University of California Department of Medicine, San Francisco General Hospital: John F. Murray, M.D. Award    for academic excellence and dedication to the humanitarian mission of San Francisco General Hospital
2009: Japan Antituberculosis Association and International Union against Tuberculosis and Lung Diseases: Princess Chichibu Award for contributions to global TB control.

Keywords/Areas of Interest:
Tuberculosis, public health, epidemiology, pulmonary complications of HIV

PROFESSIONAL ACTIVITIES:
Clinical: Attending physician, Pulmonary Consultation Service and Medical Intensive Care Unit, San Francisco General Hospital, 2 months/year.
Attending physician, San Francisco Department of Public Health Tuberculosis Clinic, variable

Non-UCSF Professional Activities

State and Local Agency Advisory/Consultant Positions:
State of Washington, Department of Health and Social Services, Division of Tuberculosis Control, 1978-84
State of California, Department of Health, Infectious Disease Section, 1977-present
State of Texas, Department of Health, Division of Tuberculosis Control, 1978, 1999
State of New Jersey Tuberculosis Control Program, 1989-90
Los Angeles County, Tuberculosis Control Program, 1992
State of Hawaii, Tuberculosis Control Program, 1993
Commonwealth of Virginia, Tuberculosis Control Program, 2000
American Thoracic Society, Senior Advisor, International Activities, 2006-present

International Advisory/Consultant Positions & Committees:
Government of Nigeria, Ministry of Health, Tuberculosis Control, 1969-70
Government of Peru, Ministry of Health, Tuberculosis Control Program, 1981-86
Tuberculosis Consortium for Technical Assistance (Funded by USAID) Board of Directors 2000-Present
Forum of International Respiratory Societies, Board of Directors, 2001-2009
Global Fund against AIDS, Tuberculosis, and Malaria, Consultant, 2003
Bill and Melinda Gates Foundation, Consortium to Respond Effectively to the AIDS TB Epidemic:    Data Safety and    Monitoring Board, Chair 2005-present
Tropical Disease Research Program, World health Organization: Timing of antiretroviral treatment in patients with HIV infection, Data Safety and Monitoring Board, Chair 2007-present

Professional Organizations:
American Thoracic Society (ATS)
Elected Positions
Secretary, Scientific Assembly on Tuberculosis, 1975-76
Chair, Scientific Assembly on Tuberculosis, 1978-79
Board of Directors, 1990-91, 1993-98
Vice-president, 1990-91
Secretary-Treasurer, 1993-94
Vice-president, 1994-95
President-elect, 1995-96
President, 1996-97
Past-president, 1997-98

 ATS Committees (appointed)
Committee on Indian Health Service, 1972-75
Medical Devices Committee, 1974-78
Committee on Research Review, 1974-77, 1986-90
Committee on Tuberculosis in Aliens and Migrants, 1975
Chairman, Committee on Discharge of Tuberculosis Patients from Medical Surveillance, 1975-76
Program Committee, Scientific Assembly on Tuberculosis, 1975-79
Annual Meeting Committee, 1978-79
Committee on the Tuberculin Skin Test, 1980-81
Nominating Committee, 1982-83
Scientific Assembly on Microbiology and Pulmonary Infection - Nominating Committee, 1983
Committee on Tuberculosis Statements 1983-2000
Chairman, Committee on International Affairs, 1985-90
Committee on Tuberculosis Research, 1987-89
World Conference Organizing Committee, 1988-90
Trudeau Medal Committee, 1989
Council of Chapter Representatives, 1990-1995
Planning Committee, 1990-92 (Chairman 1993-95)
Chairman, World Lung Health Committee, 1992-94
Chairman, Program and Budget Committee, 1993-94
World Lung Health Committee, 1998-2004
Search Committee for Editor, Am Rev Respir Crit Care Med, 1998
Co-Chair Tuberculosis Treatment Recommendations Statement Committee 2001-2003
International Relations Committee (Chairman), 2000-2004
Methods in Epidemiological, Clinical, and Operations Research course faculty 2002-present
International Lung Health Committee (Co-chair), 2004-2006
Nominating committee, 2005-06
World Lung Health Committee 2006-present
Task Force on Publications, Chair, 2008
Task Force on International Participation, 2011

California Thoracic Society (CTS)
Elected Positions
Treasurer, 1984-85
Secretary, 1985-86
President-elect, 1986-87
President, 1987-88
Executive Committee, 1984-88, 1990-95

 CTS Committees (appointed)
Postgraduate Course Committee, 1974-77
Committee on Tuberculosis, 1975-79
Committee on Professional Education, 1978-79, 1983
Chairman, Nominating Committee, 1978-79
Annual Meeting Committee, 1979-80
Long-range Planning Committee 1985
Nominating Committee, 1988-89, 1998
California Medal Committee, 1989-93
Representative to ATS Council, 1990-95
Committee on Revenue Generation, 2004

California Tuberculosis Controller's Association (CTCA)
Elected Positions
Secretary, 1983-84
Vice-president, 1984-85
President, 1985-86
Executive Committee, 1984-87

CTCA Committees (appointed)
Research Committee, 1980-90

American Federation for Clinical Research
Program Committee for Pulmonary Disease, 1980

Western Association of Physicians

Service to Professional Publications:
Associate Editor, American Review of Respiratory Disease, 1978-79
Editorial Board, American Review of Respiratory Disease, 1985-91
Editorial Board, Seminars in Respiratory Infections, 1987-94
Editorial Advisory Committee, Tubercle and Lung Disease, 1993-97
Associate Editor, Tubercle and Lung Disease, 1997-2003
International Advisory Committee Thorax, 2002-present
Editorial Board Public Library of Science: Medicine, 2004-Present

Ad hoc reviewer
AIDS
American Journal of Medicine
American Journal of Public Health
American Review of Respiratory Disease (Now American Journal of Respiratory and Critical Care Medicine)
Annals of Internal Medicine
Bulletin of the World health Organization
Chest
Circulation
Clinical Infectious Disease
Critical Care Medicine
Emerging Infections
Epidemiologic Reviews
European Journal of Clinical Microbiology
European Respiratory Journal
Gastroenterology
HIV: Advances in Research and Therapy
International Journal of Tuberculosis and Lung Disease
Journal of Acquired Immunodeficiency Syndrome
Journal of Infectious Disease
Journal of Respiratory Diseases
Journal of the American Medical Association
Lancet
Nature Medicine
New England Journal of Medicine
Public Health Reports
Public Library of Science (PLoS): Medicine
PLoS One
Thorax
Tubercle and Lung Disease
Western Journal of Medicine 

GOVERNMENT AND OTHER PUBLIC SERVICE

Government Service: Federal Government Agency AdvisoryCommittees

Food & Drug Admin. Anesthesiology Devices Classification Panel, 1976-81, Panel Chairman, 1979-80
National Heart, Lung and Blood Institute, Task Force on Pulmonary Technology, 1980-81
Public Health Service, Center for Disease Control, Ad Hoc Consultant, Tuberculosis Control Division, 1975-present
National Heart, Lung and Blood Institute, Ad Hoc Review Committees, 1978-80, 83, 90, 93, 94
National Center for Health Care Technology, 1980
National Research Council: Board on Science and Technology for International Development, Ad Hoc Consultant, 1984, 1985
NIH, NIAID Panel on Experimental Approaches to Developing and Testing of Antituberculosis Drugs, 1994
NIH, NIAID National Advisory Council, 1995-97
National Institutes of Health, National Institute of Allergy and Infectious Diseases. U.S.-Japan Cooperative, Medical Sciences Program, Tuberculosis and Leprosy Panel, 1992-2003 (Chair 2000-2003)
NIH-NIAID Ad Hoc review committees 2003-06
NIH-NIAID-ANRS (France) Scientific Advisory Group CAMELIA Study, 2006-present

Other Professional Service
World Health Organization/Pan American Health Organization Advisory Committees

World Health Organization, Tuberculosis and Respiratory Disease Program, 1983
World Health Organization, Global Program on AIDS, 1987-90
Pan American Health Organization, Tuberculosis Control Program, 1992, 2002
World Health Organization, Tuberculosis Program, Comm. on Therapy of Mycobacterial Diseases, 1993-98
World Health Organization, Tuberculosis Program, Committee to Review Tuberculosis-HIV Interaction, 1995
World Health Organization, Tuberculosis Program, Committee to Review Research Strategy, 1995
World Health Organization, Stop Tuberculosis Department, Strategic and technical Advisory Group. 2002-present (Vice-chair, 2004)
World health Organization, Stop Tuberculosis Partnership, Public-Private Mix Working Group (Chair) 2002-present
World Health Organization, Stop Tuberculosis Partnership, Vaccine Working Group (2002-2006)
World Health Organization, Stop Tuberculosis Partnership, DOTS Expansion Working Group 2000-present (Core Group 2003-present)
World Health Organization, Joint External Monitoring Mission for Indonesia National TB Program, April 2007, March 2011.
World Health Organization, Global Alliance against Respiratory Disease, Planning Committee, 2007-present
World health Organization/Tropical Disease Research: Data Safety and Monitoring Board, Timing of Antiretroviral Treatment in Patients with TB and HIV Infection, Chair, 2008-present
World Health Organization Stop TB Department, Technical Development Committee. Global tuberculosis treatment recommendations 2008-2010
World health Organization, HIV/AIDS Department, Integrated Management of Adult Illness Advisory Group, 2009-present

Miscellaneous Positions:
American Medical Association - Technology Review Panel, 1981-90
Infectious Disease Society, Antimycobacterial Drug Committee (Chairman), 1989-93
American Board of Internal Medicine, Subspecialty Board on Pulmonary Disease, 1992-96
Scientific Advisory Board, Tuberculosis Research Unit, Case Western Reserve University, 1995-99
Institute of Medicine, Committee on Elimination of Tuberculosis in the United States, 1999-2000
Board of Directors, Tuberculosis Coalition for Technical Assistance, 2000-present
Coordinator and co-chair, Steering Committee, International Standards for Tuberculosis Care, 2004- present

UNIVERSITY AND PUBLIC SERVICE
Campus and School of Medicine:
1978-1980: Representative, Academic Assembly, San Francisco Division
1980-1982: Educational Policy Committee
1998-2003:UCSF Long-range Development Plan Committee
1998-2004: School of Medicine Executive Committee
2005-present: Senior Leadership Group, Clinical and Translational Science Award
2005-2006: Strategic Planning Group, Global Health Sciences
2005-2007: Steering Committee Global Health Sciences

Department of Medicine Activities:
1978-1980:Intern Selection Committee
1980-present: Ad Hoc Promotion Committees
19881989:Finance Committee
1989-1990:Incentive Plan Committee
1983-1990:UCSF Task Force on AIDS
1986-1997:SFGH Medicine Service, Executive Committee
2007-2008: Search committee Chief of Medicine Service, SFGH

San Francisco General Hospital Service:
1972-1985, 1993-1998: Critical Care Committee, (Chairman 1979-81),
1973-1976: Utilization Review Committee,
1977-1979: Credentials Committee,
1977-1990: Associate Director, Respiratory Therapy,
1973-1977: Intern Selection Committee,
1973-1975: Outpatient Clinic Committee,
1978-1980: Family Practice Ward Committee,
1986-1988: Emergency Room Committee,
1987-1988: Organized Health Service Program Planning Committee,
1991-1992: Invasive Procedures Committee (Chairman),
1998-2003: Community Health Network Leadership Group,
1998-2003: Medical Staff Executive Committee,
1998-2003: Housestaff Committee
1998-2003: Provider-Hospital Organization Executive Committee
1998-2003: Clinical Practice Group, Executive Committee
2005-2007: Long-range Development Plan Committee

Community and Public Service:
American Lung Association (ALA) Elected Positions
Council, 1990-91, 1993-99
Board of Directors, 1995-98

ALA Committees (appointed)
Program Coordinating Committee, 1994-96
Program and Budget Committee, 1994-97
Strategic Planning Committee, 1994-97
World Lung Health Committee, 1999-2001

American Lung Association Of California (ALAC) Elected Positions
Board of Directors, 1986-88
Executive Committee, 1987-88

ALAC Committees (appointed)
Tuberculosis Committee, 1983-90
Committee to Review State Tuberculosis Program, 1984
Committee on Access to Health Care, 1990-91

American Lung Association Of San Francisco Committees (appointed)
Community Health Committee, 1974-77
Professional Education Committee, 1978-81

International Union Against Tuberculosis And Lung Disease (IUATLD) Committees (appointed)
Committee on Treatment, 1979-93 (Chairman, 1990-93)
Coordinator, Peru Project, 1981-86
Council, 1986-97
Project Advisory Committee, 1987-94
Executive Committee, 1991-97

North American Region - International Union Against Tuberculosis And Lung Disease
President, 1991-97
Executive Committee, 1991-1998
Program Committee, 1996-2001, 2006-2007

TEACHING AND MENTORING
Postdoctoral fellows directly supervised:
2010-Present    Charles Everett, M.D. (co mentored with Laurence Huang)
Fellow, Pulmonary and Critical Care Medicine
UCSF

2007- 2009  John Metcalfe, MD
Assistant professor
Pulmonary and Critical Care Medicine
UCSF    

2005-07
Elizabeth Fair, PhD
Assistant Professor
Pulmonary and Critical Care Medicine
UCSF

Laura Flores, PhD
Postdoctoral fellow
Pulmonary and Critical Care Medicine
UCSF

Adithya Cattamanchi, M.D.
Assistant professor (as of 7/1/09)
Pulmonary and Critical Care Medicine
UCSF

2005-06
Neil Abernathy, PhD
Assistant Professor
University of Washington

Madhukar Pai, M.D., PhD
Assistant Professor of Epidemiology
McGill University

Payam Nahid, M.D, M.P.H.   
Assistant Professor of Medicine
Division of Pulmonary and Critical Care Medicine
University of California, San Francisco

1996-97      Williamson Bradford, M.D., M.P.H.
Clinical Assistant Professor of Medicine
Division of Infectious Diseases
University of California, San Francisco
Immugen Corp

Robert Jasmer, M.D.
Clinical Assistant Professor
Division of Pulmonary and Critical Care Medicine
University of California, San Francisco
Private practice, Mills-Peninsula Hospital

1995-96     Laurence Huang, M.D.
Professor of Medicine
University of California, San Francisco
San Francisco General Hospital

Daniel Chin, M.D., M.P.H.
Tuberculosis Project
Bill and Melinda Gates Foundation
Beijing, China

Charles Daley, M.D.
Associate Professor of Medicine
Chief, Respiratory Infections Unit
University of Colorado, School of Medicine

Peter Small, M.D.
Senior Advisor, Tuberculosis
Bill and Melinda Gates Foundation
Seattle, Washington

Predoctoral students directly supervised
Janina Morrison
UCSF med student 

RESEARCH AND CREATIVE ACTIVITIES

Current Research and Technical Assistance Awards and Grants
R01 AI34238 Hopewell (PI)      
05/01/93 – 10/01/12
NIH/NIAID
Population Based Molecular Epidemiology of Tuberculosis
RFLP pattern analysis to describe the distribution and dynamics of urban tuberculosis.
Role:  PI
Current Year Direct Total:  $324,789

R01AI076476-01A1 Hopewell (PI)
07/01/09 – 06/31/14
Effect of Drug Resistance on Transmissibility and Pathogenicity of M. tuberculosis
Role: PI
Current year direct total: $256,300

U01AI088679-01 (International collaborations in Infectious Disease Research) Hopewell (PI)) 7/01/10 – 06/30/15
NIH/NIAID
Tuberculosis epidemiology and novel transmission routes in rural Tanzania
Current year direct total: $500,000

A114814  Program for Appropriate Technology in Health AID.1470-08586  Hopewell (PI) 10/1/09-9/30/10
Technical assistance for TB in Tanzania and India
Current year direct total:

2000-1999-00098 Nahid (PI)     
09/23/99 – 09/22/19
CDC
The purpose is to conduct clinical research in the areas of diagnosis and treatment of active and latent tuberculosis through multi-phase clinical trials.
Role:  Co-PI
Current Year Direct Total:  $276,025

U52/CCU900454 (prime: City & County of San Francisco)          
01/25/94 – 12/31/10
CDC -  UCSF (subcontract ,Hopewell (PI)
Establishing and operating a center for training and clinical consultation for tuberculosis for the western US.
Role:  PI
Current Year Direct Total:  $1,328,571

Peer-Reviewed Journal Articles
  1. Andrews CE, Hopewell PC, Burrell RE, Olson MO, Chick EW. An epidemic of respiratory infection due to mycoplasma pneumonia in a civilian population. Am Rev Respir Dis 95:972-979, 1967.
  2. Hopewell PC, Coder HE. School tuberculin testing. Pennsylvania Medicine 70:69-71, 1967.
  3. Johnson RF, Hopewell PC. Chemotherapy of pulmonary tuberculosis. Ann Intern Med 70:359-367, 1969.
  4. Hopewell PC, Murray JF. The effects of continuous positive pressure ventilation in experimental pulmonary edema. J Appl Physiol 4:568-574, 1976.
  5. Levinson AI, Hopewell PC, Sites DP, Spitler LE, Fudenberg HH. Coexistent lymphoid interstitial pneumonia, pernicious anemia, and agammaglobulinemia. Arch Intern Med 136:213-216, 1976.
  6. Leff A, Hopewell PC, Costello JF. Pleural effusion from malignancy. Ann Intern Med 88:532, 1978.
  7. Powell JR, Vozeh S, Hopewell PC, Costello JC, Reigelman S, Sheiner L. Theophylline disposition in acutely ill hospitalized patients: the effect of smoking, heart failure, severe airways obstruction and pneumonia. Am Rev Respir Dis 118:229-237, 1978.
  8. Vozeh S, Powell JR, Shiner L, Reigelman S, Costello JF, Hopewell PC. Changes in theophylline clearance during acute illness. JAMA 240:1882-1884, 1978.
  9. Hopewell PC. Failure of positive end-expiratory pressure to decrease lung water in alloxan-induced pulmonary edema. Am Rev Respir Dis 120:813-820, 1979.
  10. Overland ES, Nolan AJ, Hopewell PC. Alteration of pulmonary function in intravenous drug abusers: prevalence, severity and characterization of gas exchange abnormalities. Am J Med 68:59-66, 1980.
  11. Andrew OT, Schoenfeld P, Hopewell PC, Humphreys M. Tuberculosis in patients with end-stage renal disease. Am J Med 68:231-237, 1980.
  12. Fein A, Leff A, Hopewell PC. Pathophysiology and management of the complications resulting from fire and the inhaled products of combustion: review of the literature. Crit Care Med 8:94-98, 1980.
  13. Huchon GJ, Hopewell PC, Murray JF. Interactions between increased permeability and increased hydrostatic pressure on water and blood contents in perfused dog's lung. J Appl Physiol: Respirat Environ Exercise Physiol 50:905-911, 1981.
  14. Fischer MF, Hopewell PC. Recurrent pulmonary embolism as the presenting manifestation of Buerger's disease. West J Med 135:238-241, 1981.
  15. IPPB Trial Group (Anthonisen MR, Hodgkin JE, Hopewell PC, Levin DC, Stevens PS, Krueger DE, Wright EC). Intermittent positive pressure breathing therapy of chronic obstructive pulmonary disease. Ann Intern Med 99:612-620, 1983.
  16. Hopewell PC, Sanchez-Hernandez M, Baron R, Ganter B. Operational evaluation of treatment for tuberculosis: results of a "standard" 12-month regimen in Peru. Am Rev Respir Dis 129:439, 1984.
  17. Murray JF, Felton CP, Garay SM, Gottlieb MS, Hopewell PC, Stover DE, Teirstein AS. Pulmonary complications of the acquired immunodeficiency syndrome. N Engl J Med 310:1682-1688, 1984.
  18. Broaddus C, Dake MD, Stulbarg MS, Blumenfeld W, Hadley WK, Golden JA, Hopewell PC. Bronchoalveolar lavage and transbronchial biopsy for the diagnosis of pulmonary infections in the acquired immunodeficiency syndrome. Ann Intern Med 102:747-752, 1985.
  19. Hopewell PC, Ganter B, Baron RB, Sanchez-Hernandez M. Operational evaluation of treatment for tuberculosis: results of an 8-month regimen in Peru. Am Rev Respir Dis 132:737-741, 1985.
  20. Bigby TD, Margolskee D, Curtis J, Michael PF, Sheppard D, Hadley WK, Hopewell PC. The usefulness of induced sputum in the diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. Am Rev Respir Dis 133:515-518, 1986.
  21. Sullam PM, Slutkin G, Hopewell PC. The benefits of evaluating close associates of child tuberculin reactors from a high-prevalence group. Am J Public Health 76:1-3, 1986.
  22. Perez-Stable EJ, Slutkin G, Paz A, Hopewell PC. Tuberculin reactivity in U.S. and foreign-born Hispanics: result of a community-based screening program. Am J Public Health 76:643-646, 1986.
  23. Wharton JM, Coleman DL, Wofsy CB, Luce JM, Blumenfeld W, Hadley WK, Ingram Drake L, Volberding PA, Hopewell PC. Trimethoprim-sulfamethoxazole or pentamidine for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Ann Intern Med 105:37-44, 1986.
  24. Leoung G, Mills J, Hopewell PC, Hughes W, Wofsy CB. Dapsone-trimethoprim is effective treatment for Pneumocystis carinii pneumonia in patients with AIDS. Ann Intern Med 105:45-48, 1986.
  25. Coates SR, Schecter G, Slutkin G, Hopewell PC, Affronti L, Echenberg D. Identification of antigens of Mycobacterium tuberculosis in Seibert fractions by immunoblotting. J Clin Microbiol 24:126-130, 1986.
  26. Wachter RM, Luce JM, Turner J, Volberding P, Hopewell PC. Intensive care of patients with the acquired immunodeficiency syndrome: outcome and changing patterns of utilization. Am Rev Respir Dis 134:891-896; 1986.
  27. Slutkin G, Perez-Stable EJ, Hopewell PC. Time course and boosting of tuberculin reactions in nursing home residents. Am Rev Respir Dis 134:1048-1051; 1986.
  28. Montgomery AB, Debs RJ, Luce JM, Corkery KJ, Turner J, Brunette EN, Lin ET, Hopewell PC. Aerosolized pentamidine as sole therapy for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. Lancet 2:450-483, 1987.
  29. Chaisson RE, Schecter GF, Theuer CP, Rutherford GW, Echenberg DF, Hopewell PC. Tuberculosis in patients with the acquired immunodeficiency syndrome: clinical features, response to therapy, and survival. Am Rev Respir Dis 136:570-574, 1987.
  30. Lo B, Cohen NH, Wachter RM, Luce JM, Hopewell PC, Raffin TA. Ethical dilemmas about intensive care in patients with AIDS. Rev Infect Dis 9:1163-1167, 1987.
  31. Gordin FM, Perez-Stable EJ, Flaherty D, Joe L, Schecter G, Reid ME, Slutkin G, Hopewell PC. Evaluation of a third sequential tuberculin skin test in a chronic care population. Am Rev Respir Dis 137:153-157, 1988.
  32. Montgomery AB, Debs RJ, Luce JM, Corkery KJ, Turner J, Brunette EM, Lin ET, Hopewell PC. Selective delivery of pentamidine to the lung by aerosol. Am Rev Respir Dis 137:477-479, 1988.
  33. Milligan SA, Luce JM, Golden JA, Stulbarg M, Hopewell PC. Transbronchial biopsy without fluoroscopy in patients with diffuse roentgenographic infiltrates and the acquired immunodeficiency syndrome. Am Rev Respir Dis 137:486-488, 1988.
  34. Wachter RM, Cooke M, Hopewell PC, Luce JM. Attitudes of medical residents regarding intensive care of patients with the acquired immunodeficiency syndrome. Arch Intern Med 148:149-152, 1988.
  35. Perez-Stable EJ, Flaherty D, Schecter G, Slutkin G, Hopewell PC. Conversion and reversion of tuberculin reactions in nursing home residents. Am Rev Respir Dis 137:801-804, 1988.
  36. Dean NC, Golden JA, Evans LA, Warnock ML, Addison TE, Hopewell PC, Levy JA. Human immunodeficiency virus recovery from bronchoalveolar lavage fluid in patients with AIDS. Chest 93:1176, 1988.
  37. Kaplan L, Hopewell PC, Jaffe H, Goodman PC, Bottles K, Volberding P. Kaposi's sarcoma involving the lung in patients with the acquired immunodeficiency syndrome. J AIDS 1:23-30, 1988.
  38. Mills J, Leoung G, Medina I, Hopewell PC, Hughes WT, Wofsy C. Dapsone treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Antimicrob Agent Chemother 32:1057-1060, 1988.
  39. Slutkin G, Schecter GF, Hopewell PC. The results of nine month isoniazid-rifampin therapy for pulmonary tuberculosis under program conditions in San Francisco. Am Rev Respir Dis 138:1622-1624, 1988.
  40. Montgomery AB, Debs RJ, Luce JM, Corkery KJ, Turner J, Hopewell PC. Aerosolized pentamidine as second-line therapy in patients with the acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia. Chest 95:747-750, 1989.
  41. Gordin FM, Slutkin G, Schecter G, Goodman PC, Hopewell PC. Presumptive diagnosis and treatment of pulmonary tuberculosis based on radiographic findings. Am Rev Respir Dis 139:1090-1093, 1989.
  42. Ng VL, Gartner I, Weymouth LA, Goodman CD, Hopewell PC, Hadley WK. The use of mucolysed induced sputum for the identification of pulmonary pathogens associated with human immunodeficiency virus infection. Arch Pathol Lab Med 113:488-493, 1989.
  43. Rush JD, Ng VL, Hopewell PC, Hadley WK, Mills J. Comparative recovery of cytomegalovirus from saliva, mucolysed induced sputum and bronchoalveolar lavage fluid in patients at risk for or with the acquired immunodeficiency syndrome. J Clin Micro 27:2864-2865, 1989.
  44. Theuer CP, Hopewell PC, Elias D, Schecter GF, Rutherford GS, Chaisson RE. Human immunodeficiency virus infection in tuberculosis patients. J Infect Dis 162:8-12, 1990.
  45. Glassroth J, Bailey WC, Hopewell PC, Schecter G, Harden JW. Why tuberculosis is not prevented. Am Rev Respir Dis 141:1236-1240, 1990.
  46. Ng VL, Yajko DM, McPhaul LW, Gartner I, Byford B, Goodman CD, Nassos PS, Sanders CA, Howes EL, Leoung G, Hopewell PC, Hadley WK. Evaluation of an indirect fluorescent antibody stain for the detection of Pneumocystis carinii in respiratory specimens. J Clin Micro 28:975-979, 1990.
  47. Medina I, Mills J, Leoung G, Hopewell PC, Lee B, Modin G, Benowitz N, Wofsy CB. Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: a controlled trial of trimethoprim-sulfamethoxazole with trimethoprim-dapsone. N Engl J Med 323:776-782, 1990.
  48. Ng VL, Virani NA, Chaisson RE, Yajko DM, Sphar HT, Cabrian K, Rollins N, Charache P, Krieger M, Hadley WK, Hopewell PC. Rapid detection of Pneumocystis carinii using a direct fluorescent monoclonal antibody stain. J Clin Micro 28:2228-2233, 1990.
  49. Small PM, Schecter GF, Goodman PC, Sande MA, Chaisson RE, Hopewell PC. Treatment of tuberculosis in patients with advanced human immunodeficiency virus infection. N Engl J Med 324:289-294, 1991.
  50. Wachter RM, Russi MB, Bloch DA, Hopewell PC, Luce JM. Pneumocystis carinii pneumonia and respiratory failure in AIDS: improved outcomes and increased use of intensive care units. Am Rev Respir Dis 143:251‑256, 1991.
  51. Jacobson MA, Mills J, Rush J, Peiperl L, Seru V, Mohanty PK, Hopewell PC, Hadley WK, Broaddus VC, Leoung G, Feigel DW. Morbidity and mortality of patients with AIDS and first-episode Pneumocystis carinii pneumonia unaffected by concomitant pulmonary cytomegalovirus infection. Am Rev Respir Dis 144:6-9, 1991.
  52. Gordin FM, Perez-Stable EJ, Reid M, Schecter G, Cosgriff L, Hopewell PC. Stability of positive tuberculin tests: are boosted reactions valid? Am Rev Resp Dis 144:560-563, 1991.
  53. Jacobson MS, Hopewell PC, Yajko DM, Hadley WK, Lazarus E, Mohanty PK, Modin GW, Feigel DW, Cusic PA, Sande MA. Natural history of disseminated Mycobacterium avium complex infection in AIDS. J Infect Dis 164:994-998, 1991.
  54. Wachter RM, Luce JM, Hopewell PC. Critical care of patients with AIDS. JAMA 267:541-547, 1992.
  55. Daley CL, Small PM, Schecter GF, Schoolnik GK, McAdam RA, Jacobs WR, Hopewell PC. An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus--an analysis using restriction-fragment--length polymorphisms. N Engl J Med 326:231-235,1992.
  56. Janoff E, Breiman R, Daley CL, Hopewell PC. Pneumococcal disease during HIV infection. Ann Intern Med 117:314-324, 1992.
  57. Schnapp LM, Geaghan SM, Campagna A, Fahy JV, Steiger D, Ng V, Hadley WK, Hopewell PC, Stansell JD. Toxoplasma gondii pneumonitis in patients infected with the human immunodeficiency virus. Arch Intern Med 152:1073-1077, 1992.
  58. Fahy JV, Chin DP, Schnapp LM, Steiger DJ, Schaumberg TH, Geaghan SM, Klein JS, Hopewell PC. Effect of aerosol pentamidine prophylaxis of Pneumocystis carinii pneumonia. Am Rev Respir Dis 146:844-848, 1992.
  59. Ng VL, Geaghan SM, Leoung G, Shiboski S, Fahy J, Schnapp L, Yajko DM, Hopewell PC, Hadley WK. Lack of effect of aerosolized pentamidine on the detection of Pneumocystis carinii pneumonia in induced sputum or bronchoalveolar lavage specimens. Arch Pathol Lab Med 117:493-496, 1993.
  60. Yajko DM, Nassos PS, Sanders CA, Gonzalez PC, Reingold AL, Horsburgh CR, Hopewell PC, Chin DP, Hadley WK. Comparison of four decontamination methods for recovery of Mycobacterium avium Complex from stools. J Clin Micro 31:302-306, 1993.
  61. Small PM, Shafer RW, Hopewell PC, Singh SP, Murphy MJ, Desmond E, Sierra MF, Schoolnik GK. Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in patients with advanced HIV infection. N Engl J Med 328:1137-1144, 1993.
  62. Pulmonary Complications of HIV Infection Study Group.* The prospective study of pulmonary complications of human immunodeficiency virus infection. J Clin Epidemiol 46:487-507, 1993. (Dr. Hopewell chaired the Study Group.)
  63. Markowitz N, Hansen NI, Wilcosky TC, Hopewell PC, Glassroth J, Kvale PA, Mangura BT, Osmond D, Wallace JM, Rosen MJ, Reichman LB. Tuberculin and anergy testing in HIV-seropositive and HIV-seronegative persons. Ann Intern Med 119:185-193, 1993.
  64. Kvale PA, Rosen MJ, Hopewell PC, Markowitz N, Hansen N, Reichman LB, Wallace JM, Glassroth J, Fulkerson W, Meiselman L, and the Pulmonary Complications of HIV Infection Study Group. A decline in the pulmonary diffusing capacity does not indicate opportunistic lung disease in asymptomatic persons infected with the human immunodeficiency virus. Am Rev Respir Dis 148:390-395, 1993.
  65. Wallace JM, Rao AV, Glassroth J, Hansen NI, Rosen MJ, Arakaki C, Kvale PA, Reichman LB, Hopewell PC, and the Pulmonary Complications of HIV Infection Study Group. Respiratory illness in persons with human immunodeficiency virus infection. Am Rev Respir Dis 148:1523-1529, 1993.
  66. Chin DP, Hopewell PC, Yajko DM, Vittinghoff E, Horsburgh CR Jr., Hadley WK, Stone EN, Nassos PS, Ostroff SM, Jacobson MA, Matkin CC, Reingold AL. Mycobacterium avium complex in the respiratory or gastrointestinal tract and the risk of M. avium complex bacteremia in patients with human immunodeficiency virus infection. J Infect Dis 169:289-295, 1994.
  67. Kvale PA, Hansen NI, Markowitz N, Rosen MJ, Jordan MC, Meiselman L, Glassroth J, Reichman LB, Wallace JM, Stansell JD, Hopewell PC, the Pulmonary Complications of HIV Infection Study Group. Routine analysis of induced sputum is not an effective strategy for screening persons infected with human immunodeficiency virus for Mycobacterium tuberculosis or Pneumocystis carinii. Clin Infect Dis 19:410-416, 1994.
  68. Chin DP, Reingold AL, Horsburgh CR Jr., Yajko DM, Hadley WK, Elkin EP, Stone EN, Simon EM, Gonzalez PC, Ostroff SM, Jacobson MA, Hopewell PC. Predicting Mycobacterium avium complex bacteremia in patients with the human immunodeficiency virus: a prospectively validated model. Clin Infect Dis 19:668-674, 1994.
  69. Horsburgh CR Jr., Chin DP, Yajko DM, Hopewell PC, Nassos PS, Elkin EP, Hadley WK, Stone EN, Simon EM, Gonzalez P, Ostroff S, Reingold AL. Environmental risk factors for acquisition of M. avium complex in persons with human immunodeficiency virus infection. J Infect Dis 170:362-367, 1994.
  70. Chin DP, Reingold AL, Stone EM, Vittinghoff E, Horsburgh CR Jr., Simon EM, Yajko DM, Hadley WK, Ostroff SM, Hopewell PC. The impact of Mycobacterium avium complex bacteremia and its treatment on survival of AIDS patients–a prospective study. J Infect Dis 170:578-584, 1994.
  71. Small PM, Hopewell PC, Schecter GF, Chaisson RE, Goodman PC. Evolution of chest radiographs in treated patients with pulmonary tuberculosis and HIV infection. J Thoracic Imaging 9:74-77, 1994.
  72. Small PM, Hopewell PC, Singh SP, Paz A, Parsonnet J, Ruston DC, Schecter GF, Daley CL, Schoolnik GK. The epidemiology of tuberculosis in San Francisco: a population-based study using conventional and molecular methods. N Engl J Med 330:1703-1709, 1994.
  73. Glassroth J, Jordan M, Wallace JM, Kvale PA, Follmann DA, Rosen MJ, Reichman LB, Mossar M, Hopewell PC, Pulmonary Complications of HIV Study Group. Use of preventive interventions by persons infected with type-1 human immunodeficiency virus (HIV-1). Am J Prev Med 10:259-266, 1994.
  74. Huang L, Hecht FM, Stansell JD, Montanti R, Hadley WK, Hopewell PC. Suspected Pneumocystis carinii pneumonia with a negative induced sputum examination: is early bronchoscopy useful. Am J Respir Crit Care Med 151:1866-1871, 1995.
  75. Chin DP, Yajko DM, Hadley WK, Sanders CA, Nassos PS, Madej JJ, Hopewell PC. Clinical utility of a commercial test based on the polymerase chain reaction for detecting Mycobacterium tuberculosis in respiratory specimens. Am J Respir Crit Care Med 151:1872-1877, 1995.
  76. Rosen MJ, Lou Y, Kvale PA, Rao AV, Jordan MC, Miller A, Glassroth J, Reichman LB, Wallace JM, Hopewell PC, and the Pulmonary Complications of HIV Infection Study Group. Pulmonary function tests in HIV infected patients without AIDS. Am J Respir Crit Care Med 152:738-745, 1995.
  77. Gruden JF, Huang L, Webb WR, Gamsu G, Hopewell PC, Sides DM. AIDS-related Kaposi sarcoma of the lung: radiographic findings and staging system with bronchoscopic correlation. Radiology 195:545-552, 1995.
  78. Yajko DM, Chin DP, Gonzalez PC, Nassos PS, Hopewell PC, Reingold AL, Horsburgh CR, Yakrus MA, Ostroff SM, Hadley WK. Mycobacterium avium complex in water, food, and soil samples collected from the environment of HIV-infected individuals. J AIDS and Human Retrovirology 9:176-182, 1995.
  79. Blower AM, McLean AR, Porco TC, Small PM, Hopewell PC, Sanchez MA, Moss AR. The intrinsic transmission dynamics of tuberculosis epidemics. Nature Medicine 1:815-821, 1995.
  80. Opstad NL, Daley CL, Thurn JR, Rubins JB, Merrifield C, Hopewell PC, Janoff EN. Impact of Streptococcus pneumoniae bacteremia and human immunodeficiency virus type 1 on oral mucosal immunity. J Infect Dis 172:566-570, 1995.
  81. Hirschtick RE, Glassroth J, Jordan MC, Wilcosky TC, Wallace JM, Kvale PA, Markowitz N, Rosen MJ, Mangura BT, Hopewell PC, and the Pulmonary Complications of HIV Infection Study Group. Bacterial pneumonia in persons infected with the human immunodeficiency virus. N Engl J Med 333:845-851, 1995.
  82. Montgomery AB, Feigal DW Jr., Sattler F, Mason GR, Catanzaro A, Edison R, Markowitz N, Johnson E, Ogawa S, Rovzar M, Udem SA, Eden E, Hyslop N, Cheung TW, Kessler H, Mildvan D, Giron JA, Ettinger N, Crumpacker C, Frame P, Steigbigel N, Van Der Horst C, Hirsch M, Lederman MM, Hewitt RG, Fallat R, Farber HW, Sacks HS, Eisman SA, Luce JM, Boylan T, Adams M, Feinberg J, Hopewell PC. Pentamidine aerosol versus trimethoprim-sulfamethoxazole for Pneumocystis carinii in acquired immune deficiency syndrome. Am J Respir Crit Care Med 151:1068-1074, 1995.
  83. Amdahl BM, Rubins JB, Daley CL, Gilks CF, Hopewell PC, Janoff EN. Impaired natural immunity to pneumolysin during human immunodeficiency virus infection in the United States and Africa. Am J Respir Crit Care Med 152:2000-2004, 1995.
  84. Schneider RF, Hansen NI, Rosen MJ, Kvale PA, Fulkerson WJ Jr, Goodman P, Meiselman L, Glassroth J, Reichman LB, Wallace JM, Hopewell PC, and the Pulmonary Complications of HIV Infection Study Group. Lack of usefulness of radiographic screening for pulmonary disease in asymptomatic HIV-infected adults. Arch Intern Med 156:191-195, 1996.
  85. Huang L, Schnapp LM, Gruden JF, Hopewell PC, Stansell JD. Presentation of AIDS-related pulmonary Kaposi’s sarcoma diagnosed by bronchoscopy. Am J Respir Crit Care Med 153:1385-1390, 1996.
  86. Blower SM, Small PM, Hopewell PC. Control strategies for tuberculosis epidemics: new models for old problems. Science 273:497-500, 1996.
  87. Chin DP, Osmond D, Page-Shafer K, Glassroth J, Rosen MJ, Reichman LB, Kvale PA, Wallace JM, Poole WK, Hopewell PC, Pulmonary Complications of HIV Infection Study Group. Reliability of anergy skin testing in persons with HIV infection. Am J Respir Crit Care Med 153:1982-1984, 1996.
  88. Poole WK, Fulkerson W, Lou Y, Kvale P, Hopewell PC, Hirschtick R, Glassroth J, Rosen M, Mangura B, Wallace J, Markowitz N, and the Pulmonary Complications of HIV Infection Study Group. Overall and cause-specific mortality in a cohort of homo-/bisexual men, injecting drug users, and female partners of HIV-infected men. AIDS 10:1257-1264, 1996.
  89. Bradford WZ, Martin JN, Reingold AL, Schecter GF, Hopewell PC, Small PM. The changing epidemiology of acquired drug-resistant tuberculosis in San Francisco, USA. Lancet 348:928-931, 1996.
  90. Markowitz N, Hansen NI, Hopewell PC, Glassroth J, Kvale PA, Mangura BT, Wilcosky TC, Wallace JM, Rosen MJ, Reichman LB, and the Pulmonary Complications of HIV Infection Study Group. Incidence of tuberculosis in the United States among HIV-infected persons. Ann Intern Med 126:123-132, 1997.
  91. Stansell JD, Osmond DH, Charlebois E, LaVange L, Wallace JM, Alexander BV, Glassroth J, Kvale PA, Rosen MJ, Reichman LB, Turner JR, Hopewell PC, and the Pulmonary Complications of HIV Infection Study Group. Predictors of Pneumocystis carinii pneumonia in HIV-infected persons. Am J Respir Crit Care Med 155:60-66, 1997.
  92. Rosen MJ, Clayton K, Schneider RF, Fulkerson W, Rao AV, Stansell J, Kvale PA, Glassroth J, Reichman LB, Wallace JM, Hopewell PC, and the Pulmonary Complications of HIV Infection Study Group. Intensive care of patients with HIV infection: utilization, critical illnesses, and outcomes. Am J Respir Crit Care Med 155:67-71, 1997.
  93. Wallace JM, Hansen NI, LaVange L, Glassroth J, Browdy BL, Rosen MJ, Kvale PA, Mangura BT, Reichman LB, Hopewell PC, and the Pulmonary Complications of HIV Infection Study Group. Respiratory disease trends in the Pulmonary Complications of HIV Infection Study Cohort. Am J Respir Crit Care Med 155:72-80, 1997.
  94. Wallace JM, Stone GS, Browdy BL, Tashkin DP, Hopewell PC, Glassroth J, Rosen MJ, Reichman LB, Kvale PA, and the Pulmonary Complications of HIV Infection Study Group. Nonspecific airway hyperresponsiveness in HIV disease. Chest 111:121-127, 1997.
  95. Gruden JF, Huang L, Turner J, Webb WR, Merrifield CR, Stansell JD, Gamsu G, Hopewell PC. High-resolution CT in the evaluation of clinically suspected Pneumocystis carinii pneumonia in AIDS patients with normal, equivocal, or nonspecific radiographic findings. Am J Radiol 169:967-975, 1997.
  96. Mazurek GH, Chin DP, Hartman S, Reddy V, Horsburgh CR Jr., Green TA, Yajko DM, Hopewell PC, Reingold AL, Crawford JT. Genetic similarity among Mycobacterium avium isolates from blood, stool, and sputum of persons with AIDS. J Infect Dis 176:976-983, 1997.
  97. Johnson CC, Wilcosky T, Kvale P, Rosen M, Stansell J, Glassroth J, Reichman L, Wallace J, Markowitz N, Thompson JE, Hopewell P, and the Pulmonary Complications of HIV Infection Study Group. Cancer incidence among an HIV-infected cohort. Am J Epidemiol 146:470-475, 1997.
  98. Jasmer RM, Ponce de Leon A, Hopewell PC, Alarcon RG, Moss AR, Paz A, Schecter GF, Small PM. Tuberculosis in Mexican-born persons in San Francisco: reactivation, acquired infection and transmission. Internat J Tuberc Lung Dis 1:536-541, 1997.
  99. Daley CL, Hahn JA, Moss AR, Hopewell PC, Schecter, GF. Incidence of tuberculosis in injection drug users in San Francisco: impact of anergy. Am J Respir Crit Care Med 157:19-22, 1998.
  100. Bradford WZ, Koehler J, El-Hajj H, Hopewell PC, Reingold AL, Agasino CB, Cave MD, Rane S, Yang Z, Crane CM, Small PM. Dissemination of Mycobacterium tuberculosis across the San Francisco Bay Area. J Infect Dis 177:1104-1107, 1998.
  101. Yeh RW, Ponce de Leon A, Agasino CB, Hahn JA, Daley CL, Hopewell PC, Small PM. Stability of Mycobacterium tuberculosis DNA genotypes. J Infect Dis 177:1107-1111, 1998.
  102. Chambers, HF, Kocagöz T, Sipit T, Turner J, Hopewell PC. Activity of amoxicillin/clavulanate in patients with tuberculosis. Clinical Infectious Diseases 26:874-877, 1998.
  103. Huang L, Hopewell PC. Bronchoscopy versus sputum induction as the initial procedure for the diagnosis of Pneumocystis carinii pneumonia in patients infected with HIV: pro sputum induction. J Bronchology 5:163-168, 1998.
  104. Lobato MN, Loeffler AM, Cole B, Hopewell PC. Detection of Mycobacterium tuberculosis in gastric aspirates collected from children: hospitalization is not necessary. Pediatrics 102:E40, 1998.
  105. Wallace JM, Lin R, Browdy BL, Hopewell PC, Glassroth J, Rosen MJ, Reichman LB, Kvale PA, Pulmonary Complications of HIV Study Group. Risk factors and outcomes associated with identification of aspergillus in respiratory specimens from persons with HIV disease. Chest 114:131-137, 1998.
  106. Behr MA, Hopewell PC, Paz EA, Kawamura LM, Schecter GF, Small PM. Predictive value of contact investigation for identifying recent transmission of Mycobacterium tuberculosis. Am J Respir Crit Care Med 158:465-469, 1998.
  107. Chin DP, DeRiemer K, Small PM, Ponce de Leon A, Steinhart R, Schecter GF, Daley CL, Moss AR, Paz EA, Jasmer RM, Agasino CB, Hopewell PC. Differences in contributing factors to tuberculosis incidence in the United States-born and foreign-born populations. Am J Respir Crit Care Med 158:1797-1803, 1998.
  108. Lobato MN, Hopewell PC. Mycobacterium tuberculosis infection after travel to or contact with visitors with a high prevalence of tuberculosis. Am J Respir Crit Care Med 158:1871-1875, 1998.
  109. Behr MA, Warren SA, Salamon H, Hopewell PC, Ponce de Leon A, Daley CL, Small PM. Transmission of Mycobacterium tuberculosis from AFB smear-negative patients. Lancet 353:444-449, 1999.
  110. Huang L, Stansell J, Osmond D, Turner J, Page Shafer K, Fulkerson W, Kvale P, Wallace J, Rosen M, Glassroth J, Reichman L, Hopewell P, Pulmonary Complications of HIV Infection Study Group. Performance of an algorithm to detect Pneumocystis carinii pneumonia in symptomatic HIV-infected persons. Chest 115:1025-1032, 1999.
  111. Jasmer RM, Hahn JA, Small PM, Daley CL, Behr MA, Moss AR, Schecter GF, Paz EA, Hopewell PC. A molecular epidemiologic analysis of tuberculosis trends in San Francisco, 1991-1997. Ann Intern Med 130:971-978, 1999.
  112. Osmond DH, Chin DP, Glassroth J, Kvale PA, Wallace JM, Rosen MJ, Reichman LB, Poole WK, Hopewell PC, Pulmonary Complications of HIV Study Group. Impact of bacterial pneumonia and Pneumocystis carinii pneumonia on human immunodeficiency virus disease progression. Clin Infect Dis 29:536-543, 1999.
  113. Hopewell PC. Translating discoveries into control of tuberculosis in HIV-infected persons. Internat J Tuberc Lung Dis 4:S82-S87, 2000.
  114. DeRiemer K, Rudoy I, Schecter GF, Hopewell PC, Daley CL. The epidemiology of tuberculosis diagnosed after death in San Francisco, 1986-1995. Internat J Tuberc Lung Dis 3:488-493, 1999.
  115. Yeh RW, Hopewell PC, Daley CL. Simultaneous infection with two strains of Mycobacterium tuberculosis identified by restriction fragment length polymorphism analysis. Internat J Tuberc Lung Dis 3:537-539, 1999.
  116. Borgdorff MW, Behr MA, Nagelkerke NJD, Hopewell PC, Small PM. Transmission of tuberculosis in San Francisco and its association with immigration and ethnicity. Internat J Tuberc Lung Dis 4:287-294, 2000.
  117. Moss AR, Hahn JA, Tulsky JP, Daley CD, Small PM, Hopewell PC. Tuberculosis in the homeless. A prospective study. Am J Respir Crit Care Med 162:460-464, 2000.
  118. Morris AM, Huang L, Bacchetti P, Turner J, Hopewell PC, Wallace JM, Kvale PA, Rosen MJ, Glassroth J, Reichman LB, Stansell JD, Pulmonary Complications of HIV Study Group. Permanent declines in pulmonary function following pneumonia in human immunodeficiency virus-infected persons. Am J Respir Crit Care Med 162:612-616, 2000.
  119. Jasmer RM, Snyder DC, Chin DP, Hopewell PC, Cuthbert SS, Paz EA, Daley CL. Twelve months of isoniazid compared with four months of isoniazid and rifampin for persons with radiographic evidence of previous tuberculosis: an outcome and cost-effectiveness analysis. Am J Respir Crit Care Med 162:1648-1652, 2000.
  120. Rhee JT, Tanaka MM, Behr MA, Agasino CB, Paz EA, Hopewell PC, Small PM. Use of multiple markers in population-based molecular epidemiologic studies of tuberculosis. Internat J Tuberc Lung Dis 4:1111-1119, 2000.
  121. Poole WK, Perritt R, Shah KB, Lou Y, Turner J, Kvale P, Hopewell PC, Glassroth J, Rosen M, Reichman L, Wallace J, and the Pulmonary Complications of Immunodeficiency Virus Infection Study Group. A characterization of patient drop-outs in a cohort of HIV positive homosexual/bisexual men and intravenous drug users. J Epidemiol Comm Health 55:66-67, 2001.
  122. Jasmer RM, Saukkonen JJ, Blumberg HM, Daley CL, Bernardo J, Vittinghoff E, King MD, Kawamura LM, Hopewell PC.  Short-Course Rifampin and Pyrazinamide for Tuberculosis Infection (SCRIPT) Study. Short-course rifampin and pyrazinamide compared with isoniazid for latent tuberculosis infection: a multicenter clinical trial. Ann Intern Med 137:640-647, 2002.
  123. Jasmer RM, Nahid P, Hopewell PC. Clinical practice. Latent tuberculosis infection. N Engl J Med 347:1860-1866, 2002.
  124. Blumberg HM, Burman WJ, Chaisson RE, Daley CL, Etkind SC, Friedman LN, Fujiwara P, Grzemska M, Hopewell PC, Iseman MD, Jasmer RM, Koppaka V, Menzies RI, O'Brien RJ, Reves RR, Reichman LB, Simone PM, Starke JR, Vernon AA.  American Thoracic Society, Centers for Disease Control and Prevention and the Infectious Diseases Society (Hopewell P, Blumberg H, O’Brien R Cochairs). American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J Respir Crit Care Med 167:603-662, 2003.
  125. Burgos M, DeReimer K, Hopewell PC, Small PM, Daley CL. Effect of drug resistance on the generation of secondary cases of tuberculosis.J Infect Dis 188:1878-1884, 2003.
  126. Ong A, Creasman J, Hopewell PC, Gonzalez L, Wong M, Jasmer RM, Daley CL.  A molecular epidemiological assessment of extrapulmonary tuberculosis in San Francisco. Clin Infect Dis 38:25-31, 2004.
  127. Jasmer RM, Snyder DC, Saukkonen JJ, Hopewell PC, Bernardo J, King MD, Kawamura LM, Daley CL, Short-course rifampin and pyrazinamide for tuberculosis infection study group. Short-course rifampin and pyrazinamide compared with isoniazid for latent tuberculosis infection: a cost effectiveness analysis based on a multicenter clinical trial. Clin Infect Dis 38:25-31, 2004.
  128. Burgos M, Gonzalez LC,  Paz EA, Gournis E,  Kawamura L M,  Schecter G , Hopewell PC, Daley CL.  Treatment   of multidrug-resistant tuberculosis in San Francisco: an outpatient-based approach. Clin Infect Dis 40:968-975, 2005.
  129. Chambers HF, Turner J, Schecter GF, Kawamura M, Hopewell PC. Imipenem for treatment of tuberculosis in mice and humans. Antimicrob Agents Chemother 49:2816-2821, 2005.
  130. Tappero JW, Bradford WZ, Agerton TB, Hopewell P, Reingold AL, Lockman S, Oyewo A, Talbot EA, Kenyon TA, Moeti TL, Moffat HJ, Peloquin CA. Serum concentrations of antimycobacterial drugs in patients with pulmonary tuberculosis in Botswana. Clin Infect Dis 41:461-469, 2005.
  131. Gagneux S, DeRiemer K, Van T, Kato-Maeda M, de Jong BC, Narayanan S, Nicol M, Niemann S, Kremer K, Gutierrez MC, Hilty M, Hopewell PC, Small PM. Variable host-pathogen compatibility in Mycobacterium tuberculosis. PNAS 103:2869-2873, 2006.
  132. Nahid P, Pai M, Hopewell PC. Advances in diagnosis and treatment of tuberculosis. Proc Am Thoracic Society 3:103-110, 2006.
  133. Cattamanchi A, Hopewell PC, Gonzalez LC, Osmond DH, Kawamura  LM, Daley CL, Jasmer RM. A thirteen-year molecular epidemiological analysis of tuberculosis in San Francisco. Internat J Tuberc Lung Dis 10:297-304, 2006.
  134. Gagneux S, Burgos M, DeRiemer K, Encisco A, Munoz S, Hopewell PC, Small PM, Pym AS. Impact of bacterial genetics on transmission of isoniazid resistant Mycobacterium tuberculosis. PLoS Pathog 2:e61, 2006.
  135. Steingart KR, Henry M, Ng V, Hopewell PC, Ramsey A, Cunningham J, Urbancizk R, Perkins M, Aziz MA, Pai M. Fluorescence versus conventional sputum smear microscopy for tuberculosis: a systematic review.
    Lancet Infect Dis 6(9):570-581, 2006.
  136. Steingart KR, Ng V, Henry M, Hopewell PC, Ramsey A, Cunningham J, Urbancizk R, Perkins M, Aziz MA, Pai M. Sputum processing methods to improve the sensitivity of smear microscopy for tuberculosis: a systematic review. Lancet Infect Dis 6:664-674, 2006.
  137. Hopewell PC, Pai M, Maher D, Uplekar M, Raviglione MC. International Standards for Tuberculosis Care. Lancet Infect Dis 6:710-725, 2006.
  138.  Boulware DR, Daley CL, Merrifield C, Hopewell PC, Janoff EN. Rapid diagnosis of pneumococcal pneumonia among HIV-infected adults with urine antigen detection. J Infect. 55:  2007; 300-9.
  139. Wu B, Huang C, Kato-Maeda M, Hopewell PC, Daley CL, Krensky AM, Clayberger C. Messenger RNA expression of IL-8, FOXP3, and IL-12beta differentiates latent tuberculosis infection from disease. J Immunol 178:3688-3694, 2007.
  140. Nahid P, Gonzalez LC, Rudoy I, de Jong BC, Unger A, Kawamura LM, Osmond DH, Hopewell PC, Daley CL. Treatment outcomes of patients with HIV and tuberculosis. Am J Respir Crit Care Med 8, 2007 [E-pub ahead of print]
  141. DeRiemer K, Kawamura LM, Hopewell PC, Daley CL. Quantitative impact of human immunodeficiency virus infection on tuberculosis dynamics. Am J Respir Crit Care Med 176: 2007; 936-44.
  142. Mase, S. R., Ramsay, A., Ng, V., Henry, M., Hopewell, P. C., Cunningham, J., Urbanczik, R., Perkins, M. D., Aziz, M. A., and Pai, M., Yield of serial sputum specimen examinations in the diagnosis of pulmonary tuberculosis: a systematic review, Int J Tuberc Lung Dis, 11: 2007; 485-92
  143. Steingart, K. R., Henry, M., Laal, S., Hopewell, P. C., Ramsay, A., Menzies, D., Cunningham, J., Weldingh, K., Pai, M., Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: a systematic review, PLoS Med, 4: 2007;e202 .
  144. Steingart, K. R., Henry, M., Laal, S., Hopewell, P. C., Ramsay, A., Menzies, D., Cunningham, J., Weldingh, K., Pai, M., A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis, Thorax, 62: 2007; 911-17.
  145. Wu, B., Huang, C., Kato-Maeda, M., Hopewell, P. C., Daley, C. L., Krensky, A. M., and Clayberger, C., IL-24 modulates IFN-gamma expression in patients with tuberculosis, Immunol Lett 2007.
  146. Wu, B., Huang, C., Kato-Maeda, M., Hopewell, P. C., Daley, C. L., Krensky, A. M., and Clayberger, C., Messenger RNA expression of IL-8, FOXP3, and IL-12beta differentiates latent tuberculosis infection from disease, J Immunol, 178: 2007; 3688-3692.
  147. Walter, N. D., Jasmer, R. M., Grinsdale, J., Kawamura, L. M., Hopewell, P. C., and Nahid, P., Reaching the limits of tuberculosis prevention among foreign-born individuals: a tuberculosis-control program perspective, Clin Infect Dis, 46: 2008, 103-110
  148. Wu, B., Huang, C., Kato-Maeda, M., Hopewell, P. C., Daley, C. L., Krensky, A. M., Clayberger, C., IL-9 is associated with an impaired Th1 immune response in patients with tuberculosis, Clin Immunol, 126: 2008; 202-210.
  149. Wu B, Huang C, Kato-Maeda M, Hopewell PC, Daley CL, Krensky AM, Clayberger C. IL-24 modulates IFN-gamma expression in patients with tuberculosis. Immunol Lett. 117: 2008 ; 57-62. Epub 2007 Dec 26
  150. Morrison J, Pai M, Hopewell PC. Tuberculosis and latent tuberculosis infection in close contacts of people with pulmonary tuberculosis in low-income and middle-income countries: a systematic review and meta-analysis. Lancet Infect Dis.8: 2008; 359-68. Epub 2008 Apr 29
  151. Cattamanchi A, Davis JL, Worodria W, Yoo S, Matovu J, Kiidha J, Nankya F, Kyeyune R, Andama A, Joloba M, Osmond D, Hopewell P, Huang L.. Poor performance of universal sample processing method for diagnosis of pulmonary tuberculosis by smear microscopy and culture in Uganda. J Clin Microbiol. 46: 2008;3325-9. Epub 2008 Aug 13
  152. Steingart KR, Dendukuri N, Henry M, Schiller I, Nahid P, Hopewell PC, Ramsay A, Pai M, Laal S. Performance of purified antigens for serodiagnosis of pulmonary tuberculosis: a meta-analysis. Clin Vaccine Immunol. 2008
  153. Cattamanchi A, Dantes RB, Metcalfe JZ, Jarlsberg LG, Grinsdale J, Kawamura LM, Osmond D, Hopewell PC, Nahid P. Clinical characteristics and treatment outcomes of patients with isoniazid-monoresistant tuberculosis. Clin Infect Dis. 48: 2009;179-85
  154. Pai M, Joshi R, Dogra S, Zwerling AA, Gajalakshmi D, Goswami K, Reddy MV, Kalantri A, Hill PC, Menzies D, Hopewell PC. T-cell assay conversions and reversions among household contacts of tuberculosis patients in rural India. Int J Tuberc Lung Dis. 13: 2009; 84-92.
  155. Cattamanchi A, Dowdy DW, Davis JL, Worodria W, Yoo S, Joloba M, Matovu J, Hopewell PC, Huang L. Sensitivity of direct versus concentrated sputum smear microscopy in HIV-infected patients suspected of having pulmonary tuberculosis. BMC Infect Dis. 9: 2009; 53
  156. Chideya S, Winston CA, Peloquin CA, Bradford WZ, Hopewell PC, Wells CD, Reingold AL, Kenyon TA, Moeti TL, Tappero JW. Isoniazid, rifampin, ethambutol, and pyrazinamide pharmacokinetics and treatment outcomes among a predominantly HIV-infected cohort of adults with tuberculosis from Botswana. Clin Infect Dis. 48: 2009; 1685-94.
  157. Cattamanchi A, Davis JL, Worodria W, den Boon S, Yoo S, Matovu J, Kiidha J, Nankya F, Kyeyune R, Byanyima P, Andama A, Joloba M, Osmond DH, Hopewell PC, Huang. Sensitivity and specificity of fluorescence microscopy for diagnosing pulmonary tuberculosis in a high HIV prevalence setting. Int J Tuberc Lung Dis. 13: 2009;1130-6.
  158. Metcalfe JZ, Cattamanchi A, Vittinghoff E, Ho C, Grinsdale J, Hopewell PC, Kawamura LM, Nahid P. Evaluation of Quantitative Interferon-{gamma} Response for Risk Stratification of Active Tuberculosis Suspects Am J Respir Crit Care Med. 2009 Oct 1. [Epub ahead of print
  159. Flores L, Jarlsberg LG, Kim EY, Osmond D, Grinsdale J, Kawamura M, Desmond E, Hopewell PC, Kato-Maeda M. Comparison of restriction fragment length polymorphism with the polymorphic guanine-cytosine-rich sequence and spoligotyping for differentiation of Mycobacterium tuberculosis isolates with five or fewer copies of IS6110. J Clin Microbiol. 2010 Apr;48(4):1422-4. Epub 2010 Feb 10.
  160. Kim EY, Nahid P, Hopewell PC, Kato-Maeda M. Novel hot spot of IS6110 insertion in Mycobacterium tuberculosis. J Clin Microbiol. 2010 Apr;48(4):1422-4. Epub 2010 Feb 10.
  161. Cattamanchi A, Ssewenyana I, Davis JL, Huang L, Worodria W, den Boon S, Yoo S, Andama A, Hopewell PC, Cao H. Role of interferon-gamma release assays in the diagnosis of pulmonary tuberculosis in patients with advanced HIV infection. BMC Infect Dis. 2010 Mar 20;10:75
  162. Kato-Maeda M, Kim EY, Flores L, Jarlsberg LG, Osmond D, Hopewell PC. Differences among sublineages of the East-Asian lineage of Mycobacterium tuberculosis in genotypic clustering. Int J Tuberc Lung Dis. 2010;14:538-44
  163. Cattamanchi A, Davis JL, Pai M, Huang L, Hopewell PC, Steingart KR Does bleach processing increase the accuracy of sputum smear microscopy for diagnosing pulmonary tuberculosis? An updated systematic review and meta-analysis. J Clin Microbiol. 2010 Apr 26. [Epub ahead of print]
  164. Nahid P, Bliven EE, Kim EY, Mac Kenzie WR, Stout JE, Diem L, Johnson JL, Gagneux S, Hopewell PC, Kato-Maeda M; Tuberculosis Trials Consortium. Influence of M. tuberculosis lineage variability within a clinical trial for pulmonary tuberculosis. PLoS One. 2010 May 20;5(5):e10753.
  165. Horne DJ, Royce SE, Gooze L, Narita M, Hopewell PC, Nahid P, Steingart KR. Sputum monitoring during tuberculosis treatment for predicting outcome: systematic review and meta-analysis.6 :2010 ;387-94
  166. Worodria W, Davis JL, Cattamanchi A, Andama A, den Boon S, Yoo SD, Hopewell PC, Huang L. Bronchoscopy is useful for diagnosing smear-negative tuberculosis in HIV-infected patients. Eur Respir J.36:  2010p; 446-8.
  167. Metcalfe JZ, Kim EY, Lin SY, Cattamanchi A, Oh P, Flood J, Hopewell PC, Kato-Maeda M. Determinants of multidrug-resistant tuberculosis clusters, California, USA, 2004-2007. Emerg Infect Dis. 16: 2010; 1403
  168. Cattamanchi A, Huang L, Worodria W, den Boon S, Kalema N, Katagira W, Byanyima P, Yoo S, Matovu J, Hopewell PC, Davis JL. Integrated Strategies to Optimize Sputum Smear Microscopy: A Prospective Observational Study. Am J Respir Crit Care Med. 2010 Sep 17. [Epub ahead of print]
  169. Nahid P, Jarlsberg LG, Rudoy I, de Jong BC, Unger A, Kawamura LM, Osmond DH, Hopewell PC, Daley CL. Factors associated with mortality in patients with drug-susceptible pulmonary tuberculosis. BMC Infect Dis. 2011;11:1.
  170. Cattamanchi A, Smith R, Steingart KR, Metcalfe JZ, Date A, Coleman C, Marston BJ, Huang L, Hopewell PC, Pai M. Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals - A systematic review and meta-analysis. J Acquir Immune Defic Syndr. 2010 Dec 25. [Epub ahead of print]
  171. Kato-Maeda M, Gagneux S, Flores LL, Kim EY, Small PM, Desmond EP, Hopewell PC. Strain classification of Mycobacterium tuberculosis: congruence between large sequence polymorphisms and spoligotypes. Int J Tuberc Lung Dis. 2011; 15:131-3.
  172. Steingart KR, Jotblad S, Robsky K, Deck D, Hopewell PC, Huang D, Nahid P. Higher-dose rifampin for the treatment of pulmonary tuberculosis: a systematic review. Int J Tuberc Lung Dis. 2011;15: 305-16.
  173. Davis JL, Katamba A, Vasquez J, Crawford E, Sserwanga A, Kakeeto S, Kizito F, Dorsey G, den Boon S, Vittinghoff E, Huang L, Adatu F, Kamya MR, Hopewell PC, Cattamanchi A. Evaluating Tuberculosis Case Detection via Real-time Monitoring of Tuberculosis Diagnostic Services. Am J Respir Crit Care Med. 2011 Mar 11. [Epub ahead of print.
  174. Nahid P, Horne DJ, Jarlsberg LG, Reiner AP, Osmond D, Hopewell PC, Bibbins-Domingo K. Racial differences in tuberculosis infection in United States communities: the coronary artery risk development in young adults study. Clin Infect Dis. 2011; 53 :291-4
  175. Steingart KR, Flores LL, Dendukuri N, Schiller I, Laal S, Ramsay A, Hopewell PC, Pai M Commercial serological tests for the diagnosis of active pulmonary and extrapulmonary tuberculosis: an updated systematic review and meta-analysis. PLoS Med. 2011; 8: e1001062. Epub 2011 Aug
  176. Metcalfe JZ, Everett CK, Steingart KR, Cattamanchi A, Huang L, Hopewell PC, Pai M. Interferon-γ release assays for active pulmonary tuberculosis diagnosis in adults in low- and middle-income countries: systematic review and meta-analysis. J Infect Dis. 2011; 204 Suppl 4:S1120-9.
  177. Dantes R, Metcalfe J, Kim E, Kato-Maeda M, Hopewell PC, Kawamura M, Nahid P, Cattamanchi A. Impact of isoniazid resistance-conferring mutations on the clinical presentation of isoniazid monoresistant tuberculosis. PLoS One. 2012;7(5):e37956. Epub 2012 May 23
  178. Kato-Maeda M, Shanley CA, Ackart D, Jarlsberg LG, Shang S, Obregon-Henao A, Harton M, Basaraba, RJ, Henao-Tamayo M, Barrozo JC, Rose J, Kawamura LM, Coscolla M, Fofanov VY, Koshinsky H, Gagneux S, Hopewell PC, Ordway DJ, Orme IM. Beijing sublineages of Mycobacterium tuberculosis differ in pathogenicity in the guinea pig. Clin Vaccine Immunol. 2012 Aug;19(8):1227-37. Epub 2012 Jun 20.
  179. Murray JF, Du Melle F, Hopewell PC. Evolution and Revolution: The Formation of Today's American Thoracic Society, Part 1. Am J Respir Crit Care Med. 2012 Nov 15;186(10):948-52. doi: 10.1164/rccm.201206-1004PP. Epub 2012 Jul 19
  180. Hopewell PC, du Melle F, Murray JF. Evolution and Revolution: The Formation of Today's American Thoracic Society (part 2). Am J Respir Crit Care Med. 2012 Jul 19. [Epub ahead of print]
  181. Davis JL, Cattamanchi A, Cuevas LE, Hopewell PC, Steingart KR. Diagnostic accuracy of same-day microscopy versus standard microscopy for pulmonary tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis. 2012 Oct 22. doi:pii: S1473-3099(12)70232-3. 10.1016/S1473-3099(12)70232-3. [Epub ahead of print]
Editorials and Invited Contributions
  1. Hopewell PC, Murray JF. The adult respiratory distress syndrome. Ann Rev Med 27:343-356, 1976.
  2. Hopewell PC. The adult respiratory distress syndrome - What to do until the basic scientist comes. (editorial) West J Med 128:435-436, 1978.
  3. Luce JM, Hopewell PC. The acquired immunodeficiency syndrome. Clinical Challenge in Cardiopulmonary Medicine 5:1-6, 1984.
  4. Hopewell PC, Miller WT. Pathophysiology and management of severe asthma. Clinics in Chest Medicine 5:623-634, 1984.
  5. Luce JM, Hopewell PC. Pulmonary complications of the acquired immunodeficiency syndrome. J Cardiovasc Med 9:945-957, 1984.
  6. Hopewell PC, Luce JM. Pulmonary complications of the acquired immunodeficiency syndrome. Chest 37:104-112, 1985.
  7. Bailey WC, Byrd RB, Glassroth JL, Hopewell PC, Reichman LB. Preventive treatment of tuberculosis. Chest 87:128S-132S, 1985.
  8. Hopewell PC. Pneumocystis carinii pneumonia: recommendations for treatment. Pulmonary Perspectives 2:3-7, 1985.
  9. Luce JM, Hopewell PC. The acquired immunodeficiency syndrome: a San Francisco perspective. Intensive Care Medicine 11:172-173, 1985.
  10. Hopewell PC, Cohen ML, Crawford J, et al. Improving treatment for tuberculosis. Am Rev Respir Dis 134:417-420, 1986.
  11. Hopewell PC, Luce JM. Pulmonary manifestations of the acquired immunodeficiency syndrome. Clin Immun Allergy 6:489-518, 1986.
  12. Hopewell PC. Diagnosis of Pneumocystis carinii pneumonia. Inf Dis Clin N Amer 2:409-418, 1988.
  13. Hopewell PC. Pneumocystis carinii pneumonia: Diagnosis. J Inf Dis 157:1115-1119, 1988.
  14. Grossman M, Hopewell PC, Jacobs RF, Kendig EL Jr, Smith MHD. Consensus report: management of tuberculin positive children without evidence of disease. Pediatric Infectious Disease 7:243-246, 1988.
  15. Perez-Stable EJ, Hopewell PC. Chemotherapy of tuberculosis. Semin Respir Med 9:459-469, 1988.
  16. Luce JM, Wachter RM, Hopewell PC. Intensive care of patients with the acquired immunodeficiency syndrome: time for a reassessment? (editorial) Am Rev Respir Dis 137:1261-1263, 1988.
  17. Chaisson RE, Hopewell PC. Mycobacteria and AIDS mortality. (editorial) Am Rev Respir Dis 139:1-3, 1989.
  18. Hopewell PC. Human immunodeficiency virus-associated lung disease: an overview. Semin Respir Infect 4:73-74, 1989.
  19. Hopewell PC. Tuberculosis and human immunodeficiency virus infection. Semin Respir Infect 4:111-122, 1989.
  20. Fine J, Hopewell PC. Fatal and severe asthma. Pulmonary and Critical Care Update, ACCP, Vol. 4, Lesson 126, 1989.
  21. Perez-Stable EJ, Hopewell PC. Current treatment regimens for tuberculosis: choosing the right one for your patient. Clin Chest Med 10:323-339, 1989.
  22. Luce JM, Hopewell PC. Aerosolized pentamidine for Pneumocystis carinii pneumonia. Chest 96:713‑714, 1989.
  23. Hopewell PC. Prevention of lung infections associated with human immunodeficiency virus infection. Thorax 44:1038-1044, 1989.
  24. Hopewell PC. Clinical features, diagnosis and management of tuberculosis in immunocompromised patients. Kekkaku 66:433-447, 1991.
  25. Hopewell PC. Impact of human immunodeficiency virus infection on the epidemiology, clinical features, management and control of tuberculosis. Clin Infect Dis 15:540-547, 1992.
  26. Hopewell PC, Cynamon M, Starke J, Iseman M, O'Brien R. Evaluation of new anti-infective drugs for the treatment and prevention of tuberculosis. Clin Infect Dis 15:S282-S295, 1992.
  27. Hopewell PC, Cynamon M, Starke J, Iseman M, O'Brien R: Evaluation of new anti-infective drugs for the treatment and prevention of infections caused by the Mycobacterium avium complex. Clin Infect Dis 15:S296-S306, 1992.
  28. Hopewell PC, Cynamon M, Starke J, Iseman M, O'Brien R. Evaluation of new anti-infective drugs for the treatment of disease caused by the Mycobacterium kansasii and other mycobacteria. Clin Infect Dis 15:S307-S312, 1992.
  29. Bass JB Jr., Farer LS, Hopewell PC, O'Brien R, Jacobs RF, Ruben F, Snider DE Jr., Thornton G. Treatment of tuberculosis and tuberculous infection in adults and children: recommendations of the American Thoracic Society and Centers for Disease Control. Am J Respir Crit Care Med 149:1359-1374, 1994.
  30. Hopewell PC. The baby and the bath water: the case for retaining categorical services for tuberculosis control in a reformed health care system (editorial). Am J Respir Crit Care Med 150:895, 1994.
  31. Hopewell PC. A clinical view of tuberculosis. Radiol Clin N Am 33:641-653, 1995.
  32. Hopewell PC. Immigrants and tuberculosis (letter). N Engl J Med 333:667-668, 1995.
  33. Chin DP, Hopewell PC: How to treat bacteraemic Mycobacterium avium complex disease. Lancet 346:920-921, 1995.
  34. Hopewell PC. Mycobacterium tuberculosis–an emerging pathogen? West J Med 164:33-35, 1996.
  35. Chin DP, Hopewell PC. Mycobacterial complications of HIV infection. Clin Chest Med 17:697-711, 1996.
  36. Hopewell PC. Tuberculosis in persons with human immunodeficiency virus infection: clinical and public health aspects. Semin Respir Crit Care Med 18:471-484, 1997.
  37. Hopewell PC. Using conventional and molecular epidemiological analyses to target tuberculosis control interventions in a low incidence area. Novartis Foundation Symposium, 217:42-54; discussion 54-56, 1998.
  38. Hopewell PC. Global tuberculosis control: an optimist’s perspective. Internat J Tuberc Lung Dis 3:270-272, 1999.
  39. Hopewell PC. Translating discoveries into control of tuberculosis in HIV-infected persons. Internat J Tuberc Lung Dis 4:S82-S87, 2000.
  40. Hopewell PC. Targeting tuberculosis prevention. Am J Respir Crit Care Med 162:2017-2018, 2000.
  41. Hopewell PC Tuberculosis control: how the world has changed since 1990. Bulletin World Health Org 80:427, 2002.
  42. Hopewell PC, Pai M. Tuberculosis, vulnerability, and access to quality care. JAMA 293:2790-2793; 2005.
  43. Hopewell PC, Migliori GB, Raviglione MC. Tuberculosis care and control. Bull World Health Org 84:428, 2006.
  44. Fair E, Hopewell PC, Pai M. International Standards for Tuberculosis Care: revisiting the cornerstones of tuberculosis care and control. Expert Rev Anti Infect Ther 5:61-65, 2007
  45. Pai, M., Daley, P., and Hopewell, P. C., International standards for tuberculosis care: relevance and implications for laboratory professionals, Indian J Med Microbiol, 25, 89-93 2007.
Chapters in Books
  1. Hopewell PC. Adult respiratory distress syndrome. In: Basics of Respiratory Disease. ATS, vol. 7, no. 4, 1979.
  2. Hopewell PC. Idiopathic pulmonary fibrosis, lymphoid interstitial pneumonia, hypersensitivity pneumonitis, and collagen vascular disease. In: Hinshaw HC, Murray JF, eds. Diseases of the Chest, fourth edition. Philadelphia: WB Saunders, 1980, Ch. 33.
  3. Matthay M, Hopewell PC. Adult respiratory distress syndrome: pathogenesis and management. In: Simmons DH, ed. Current Pulmonology, vol. 3. Boston: Houghton Mifflin, Co., 1981.
  4. Hopewell PC, Murray JF. Adult respiratory distress syndrome. In: Shibel EM, Moser KM, eds. Respiratory Emergencies. St. Louis: CB Mosby Co., 1977:343-356; second edition, 1982.
  5. Hopewell PC. Tuberculosis and nontuberculous mycobacterial diseases. In: Stein J, ed. Internal Medicine. Little, Brown and Co., 1982; second edition, 1986; third edition, 1990; fourth edition, 1994.
  6. Hopewell PC. Critical care medicine. In: Wyngaarden JB, Smith LH, eds. Cecil Textbook of Medicine. Philadelphia: WB Saunders Co., 1984; second edition, 1988; third edition, 1991.
  7. Hopewell PC. Pneumothorax. In: Don H, ed. Decision Making in Critical Care Medicine. Philadelphia: BC Decker Inc., 1985.
  8. Hopewell PC. Management of suspected drug overdose. In: Don H, ed. Decision Making in Critical Care Medicine. Philadelphia: BC Decker Inc., 1985.
  9. Hopewell PC. Tuberculosis. In: Cherniack RM, ed. Current Therapy of Respiratory Disease. Burlington Ontario: BC Decker Inc., 1986; second edition, 1989.
  10. Hopewell PC. Factors influencing the transmission and infectivity of Mycobacterium tuberculosis: Implication for clinical and public health management of tuberculosis. In: Sande MA, Root RK, Hudson LD, eds. Respiratory Infections. New York: Churchill Livingstone Inc., pp 191-216, 1986.
  11. Hopewell PC, Luce JM. Pulmonary manifestations of the acquired immunodeficiency syndrome. In: Flenly DC, Petty TL, eds. Recent Advances in Respiratory Medicine. Edinburgh: Churchill Livingstone, pp 45-63, 1986.
  12. Hopewell PC. Mycobacterial diseases. In: Murray JF, Nadel JA, eds. Textbook of Respiratory Medicine. Philadelphia: WB Saunders Co., 1988; 2nd edition, 1994; third edition, 2000, fourth edition 2004.
  13. Hopewell PC. Diagnosis and treatment of Pneumocystis carinii pneumonia. In: Leech JH, Sande MA, Root RK, eds. Parasitic Infections. New York: Churchill Livingstone Inc., 1988.
  14. Hopewell PC. Diagnosis of Pneumocystis carinii pneumonia. In: Sande MA, Volberding PA, eds. Medical Management of AIDS. Philadelphia: WB Saunders Co., 1988; second edition, 1990.
  15. Hopewell PC. Evaluation of the immunocompromised patient with lung disease. In: Kelly WM, ed. Textbook of Internal Medicine. Philadelphia: JB Lippencott Co., 1988; second edition, 1992; third edition, 1999.
  16. Small PM, Hopewell PC. Respiratory system. In: AIDS Knowledgebase. New York: BRS Colleague, 1989; second edition, 1994.
  17. Small PM, Hopewell PC. Mycobacterial infections. In: AIDS Knowledgebase. New York: BRS Colleague, 1989.
  18. Leoung G, Hopewell PC. Pneumocystis carinii pneumonia. In: AIDS Knowledgebase. New York: BRS Colleague, 1989; second edition, 1994.
  19. Matthay MA, Hopewell PC. Critical care for acute respiratory failure. In: Baum GL and Wolinsky E, eds. Textbook of Pulmonary Diseases. Boston: Little Brown Co., fourth edition, 1989; fifth edition, 1995.
  20. Matthay MA, Hopewell PC. Acute respiratory failure. In: George RB, Light RW, Matthay MA, Matthay RA, eds. Chest Medicine. Baltimore: Williams and Wilkins, 1990.
  21. Hopewell PC. Pulmonary infections in patients with human immunodeficiency virus infection. In: Gorbach S, Bartlett JG, Blacklow M, eds. Infectious Diseases in Medicine and Surgery. Philadelphia: WB Saunders Co., 1992.
  22. Hopewell PC. Pneumocystis carinii pneumonia: current concepts. In: Sande MA, Volberding PA, eds. Medical Management of AIDS, third edition. Philadelphia: WB Saunders Co., 1992.
  23. Hopewell PC. Tuberculosis and HIV infection. In: Reichman LB and Hershfield E, eds. Tuberculosis: A Comprehensive International Approach. Marcel Dekker Co., 1993; second edition, 2000.
  24. Hopewell PC. The role of rapid diagnostic tests for tuberculosis. In: Spencer RC, Wright EP, Newsom SWB, eds. Rapid Methods and Automation in Microbiology and Immunology. Andover, UK: Intercept Ltd, 1994.
  25. Hopewell PC, Mazur H. Pneumocystis carinii pneumonia: current concepts. In: Sande MA, Volberding PA, eds. Medical Management of AIDS, third edition. Philadelphia: WB Saunders Co., 1994.
  26. Hopewell PC. Tuberculosis in persons with HIV infection. In: Sande MA, Volberding PA, eds. Medical Management of AIDS, fourth edition. Philadelphia: WB Saunders Co., 1994.
  27. Hopewell PC. “The cure”: Organization and administration of therapy for tuberculosis. In: Porter JDH and McAdam KPWJ, eds. Tuberculosis: Back to the Future. Chichester: John Wiley Sons, 1994.
  28. Hopewell PC. Overview of clinical tuberculosis. In: Bloom BR, ed. Tuberculosis: Pathogenesis, Protection and Control. Washington DC: ASM Press, 1994; second edition 2003.
  29. Hopewell PC. Pulmonary manifestations of HIV infection. In: Bennett JC, Plum F, eds. Cecil Textbook of Medicine, 20th ed. Philadelphia: WB Saunders Co., 1996, pp. 1858-1865.
  30. Hopewell PC, Small PM. Applications of molecular epidemiology to the prevention, control, and study of tuberculosis. In: Rom W and Garay S, eds. Tuberculosis. Boston: Little, Brown and Co., 1996.
  31. Enarson DA, Hopewell PC. Treatment of tuberculosis in low-income countries. In: Gangadharam PRJ, Jenkins PA, eds. Mycobacteria II Chemotherapy. New York: Chapman & Hall, 1998.
  32. Hopewell PC. Treatment of tuberculosis in Raviglione MC Tuberculosis: A Comprehensive International Approach. New York: Informa Health Care, 2006. second edition 2009.
  33. Hopewell PC, Fair EL, Pai M. International Standards for Tuberculosis Care: Integrating Tuberculosis Care and control in Davies, PDO, Barnes PF, and Gordon SB. Clinical tuberculosis (Fourth edition) Hodder and Arnold,  London, 2008.
RESEARCH PROGRAM:

Most significant publications in past 10 years
The first 4 publications listed are derived directly from the 18-year collaboration in molecular epidemiology I developed with the San Francisco Department of Public Health Tuberculosis Control program. This collaboration provides the framework and basic infrastructure for a variety of studies linking molecular investigations of the organism to epidemiological and clinical features and outcomes of tuberculosis.
1. Burgos M, DeReimer K, Hopewell PC, Small PM, Daley CL. Effect of drug resistance on the generation of secondary cases of tuberculosis.J Infect Dis 188:1878-1884, 2003.
This paper presents the epidemiological observation that strains of M. tuberculosis that are resistant to isoniazid are less pathogenic than fully susceptible strains. I was responsible for creating the overall study framework and for critical editing and final approval of the manuscript.
2.Burgos M, Gonzalez LC,  Paz EA, Gournis E,  Kawamura L M,  Schecter G , Hopewell PC, Daley CL.  Treatment   of multidrug-resistant tuberculosis in San Francisco: an outpatient-based approach. Clin Infect Dis 40:968-975, 2005.
This paper describes the approach to treating tuberculosis caused by multi-drug resistant M. tuberculosis on a largely outpatient basis, thereby considerably reducing the costs compared with other institutions. I was responsible for creating the overall study framework and for critical editing and final approval of the manuscript
3.Gagneux S, DeRiemer K, Van T, Kato-Maeda M, de Jong BC, Narayanan S, Nicol M, Niemann S, Kremer K, Gutierrez MC, Hilty M, Hopewell PC, Small PM. Variable host-pathogen compatibility in Mycobacterium tuberculosis. PNAS 103:2869-2873, 2006.
This is one of 2 papers describing the relationship of genotypic variations among strains of M. tuberculosis on transmission and pathogenicity of the organism. I was responsible for creating the overall study framework and for critical editing of the manuscript
4. Gagneux S, Burgos M, DeRiemer K, Encisco A, Munoz S, Hopewell PC, Small PM, Pym AS. Impact of bacterial genetics on transmission of isoniazid resistant Mycobacterium tuberculosis. PLoS Pathog 2:e61, 2006.
This is the second paper describing the relationship of genotypic variations among strains of M. tuberculosis on transmission and pathogenicity of the organism. This paper builds on our epidemiological observation that isoniazid resistance is associated with reduced  pathogenicity and that the reduction is associated with a specific group of resistance-conferring mutations. I was responsible for creating the overall study framework and for critical editing of the manuscript
5. Hopewell PC, Pai M, Maher D, Uplekar M, Raviglione MC. International Standards for Tuberculosis Care. Lancet Infect Dis 6:710-725, 2006.
This paper describes the International Standards for Tuberculosis Care (ISTC). I co-chaired the committee, together with Mario Raviglione, the Director of the WHO Stop TB Department, that wrote the ISTC and was responsible for all editing and finalization of the Standards them selves and of the manuscript describing the Standards. The ISTC now widely endorsed internationally and has been translated into 6 languages

Current Research Activities
My research during the past 5 years has been focused exclusively on tuberculosis. I have focused on the community epidemiology of tuberculosis, assessed mainly by molecular epidemiological methods. For the past 18 years I have been funded by NIAID to study the molecular epidemiology of tuberculosis in San Francisco. The broad goal of these studies has been to provide information that would serve to guide tuberculosis control interventions and improve the effectiveness of control measures.  Consequently, the research has been conducted in close collaboration with the San Francisco Department of Public Health. Our studies have enabled more precise targeting of tuberculosis control interventions in San Francisco and, in part, have been responsible for a nearly 50% reduction in the annual number of incident cases in the City. Our program and methods have served as a model for population-based studies in other cities and other parts of the world
Early in the course of these studies we demonstrated that, contrary to the prevailing belief, approximately 30% of new cases of tuberculosis were, at that time, the result of recent, rather than remote, infection (reactivation of latent tuberculosis infection). During the period in which we have been conducting the molecular epidemiological analyses, the amount of tuberculosis caused by recent infection has decreased disproportionately to the overall decrease, indicating that transmission with rapid progression to active disease has been interrupted in the City.
Importantly, we have found that there is little interaction in terms of transmission between the U.S.-born and the foreign-born populations. Initially we attributed this to social mixing patterns. Subsequently, however, more precise analyses incorporating phylogeographic lineage determination has suggested that there may be specific pathogen-host compatability that accounts for a seeming predilection of specific strains of organisms to infect humans of specific races/ethnicities. This possibility is the subject of a grant application currently under review.
More recently we have shown that M. tuberculosis organisms that are resistant to isoniazid have a reduced potential for generating secondary cases, an observation that corroborates earlier in vitro data and animal studies but not shown convincingly in humans. In an analysis of the specific resistance-conferring mutations associated with the decrease in pathogenicity, we observed that this effect was limited to a group of INH resistance-conferring mutations. This observation is also the topic of a funded RO1 grant. In all of these studies Midori Kato-Maeda has played an essential role as have our collaborators, Peter Small and Sebastian Gagneux.